FB2025_01 , released February 20, 2025
Allele: Dmel\HnRNP-KKG02524
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General Information
Symbol
Dmel\HnRNP-KKG02524
Species
D. melanogaster
Name
FlyBase ID
FBal0147266
Feature type
allele
Associated gene
Dmel\HnRNP-K
Associated Insertion(s)
P{SUPor-P}HnRNP-KKG02524
Carried in Construct
Also Known As
blKG02524
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{SUPor-P}HnRNP-KKG02524
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{SUPor-P}
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  tauopathy
      modeled by Hsap\MAPTGMR.Ex.PJ
      (Ambegaokar and Jackson, 2011)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      HnRNP-K[+]/HnRNP-KKG02524 is an enhancer of visible phenotype of Hsap\MAPTGMR.Ex.PJ

      (Ambegaokar and Jackson, 2011)
      NOT Suppressor of
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      HnRNP-K[+]/HnRNP-KKG02524 is an enhancer of eye phenotype of Hsap\MAPTGMR.Ex.PJ

      (Ambegaokar and Jackson, 2011)
      NOT Suppressor of
      Statement
      Reference

      HnRNP-KKG02524, Scer\GAL4GMR.PU is a non-suppressor of eye phenotype of Scer\GAL4GMR.PU, Zzzz\CAGQ108.UAS

      (Ambegaokar and Jackson, 2011)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      One copy of HnRNP-KKG02524 does not suppress the apoptosis seen in flies overexpressing hid.

      (Ambegaokar and Jackson, 2011)
      Xenogenetic Interactions
      Statement
      Reference

      One copy of HnRNP-KKG02524 enhances the rough eye phenotype seen in flies expressing Hsap\MAPTGMR.Ex.PJ. Necrotic plaques are often seen.

      HnRNP-KKG02524 does not induce a rough eye phenotype in flies expressing Hsap\MAPTScer\UAS.S2A under the control of Scer\GAL4GMR.PS.

      Expression of HnRNP-KKG02524 does not suppress the rough eye phenotype seen in flies expressing Zzzz\CAGQ108.Scer\UAS under the control of Scer\GAL4GMR.PU.

      (Ambegaokar and Jackson, 2011)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      HnRNP-KKG02524
      blKG02524
      (Ambegaokar and Jackson, 2011, Sofola et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)