Allele Dmel\ban^{D.Scer\UAS.T:Avic\GFP-EGFP}

General Information
Symbol	Dmel\ban^{D.Scer\UAS.T:Avic\GFP-EGFP}	Species	D. melanogaster
Name		FlyBase ID	FBal0147278
Feature type	allele	Associated gene	Dmel\ban

Allele class
Mutagen	in vitro construct
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct (Brennecke et al., 2003)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	Avic\GFP^E.Scer\UAS (Brennecke et al., 2003)
Nature of the lesion	Statement Reference Construct: Consists of a 100nt fragment that includes the hairpin region of the ban gene that has been cloned into the 3' UTR of Avic\GFP^E.Scer\UAS. (Brennecke et al., 2003)
Carried in construct	P{UAS-D} (Brennecke et al., 2003, Bilen et al., 2006, Thompson and Cohen, 2006, Parrish et al., 2009, Gehrke et al., 2010)
Tagged with	T:Avic\GFP^EGFP (Brennecke et al., 2003)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| pupal stage, with Df(3L)ban^Δ1, Scer\GAL4^unspecified (Brennecke et al., 2003) neuroanatomy defective \| larval stage, with Scer\GAL4^C855a (Richter et al., 2011)
Phenotype Manifest In
	embryonic/larval optic lobe \| larval stage, with Scer\GAL4^C855a (Richter et al., 2011) larval segment, with Scer\GAL4^en-e16E (Brennecke et al., 2003) wing \| posterior, with Scer\GAL4^en-e16E (Brennecke et al., 2003)
Detailed Description
	Statement Reference Expression of ban[D.Scer\UAS.T:Avic\GFP-EGFP] under the control of Scer\GAL4[C855a] results in overproliferation of the optic lobe neuroepithelia in larvae. (Richter et al., 2011) When ban^{D.Scer\UAS.T:Avic\GFP-EGFP} is driven by Scer\GAL4^en-e16E overgrowth is seen in the posterior compartment of the wing and of segments in the larval body. (Brennecke et al., 2003)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference ban^{D.Scer\UAS.T:Avic\GFP-EGFP}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a suppressor of increased cell death phenotype of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bilen et al., 2006) ban^{D.Scer\UAS.T:Avic\GFP-EGFP}/Scer\GAL4^αTub84B.PL is a suppressor of increased cell death \| somatic clone phenotype of yki^{Scer\FRT.αTub84B} (Thompson and Cohen, 2006)
Phenotype Manifest In
Suppressor of
Statement Reference ban^{D.Scer\UAS.T:Avic\GFP-EGFP}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bilen et al., 2006) ban^{D.Scer\UAS.T:Avic\GFP-EGFP}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF is a suppressor of retina phenotype of Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF (Bilen et al., 2006)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference Expression of ban[D.Scer\UAS.T:Avic\GFP-EGFP], bearing only a 100bp region containing the ban miRNA suppresses degeneration in Hsap\MJD[tr.Q78.Scer\UAS.T:Ivir\HA1] Scer\GAL4[GMR.PF] flies, restoring external and internal eye structures towards normal. (Bilen et al., 2006)
Complementation & Rescue Data
Rescues	ban^{D.Scer\UAS.T:Avic\GFP-EGFP}/Scer\GAL4[-] rescues Df(3L)ban^Δ1 (Brennecke et al., 2003)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	ban^{D.Scer\UAS.T:Avic\GFP-EGFP}
Name Synonym
Secondary FlyBase IDs

References ( 6 )
Research paper	Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. [FBrf0215050] Gehrke et al., 2010, Nature 466(7306): 637--641 Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression. [FBrf0211387] Parrish et al., 2009, Neuron 63(6): 788--802 The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in drosophila sensory neurons. [FBrf0208858] Bilen et al., 2006, Mol. Cell 24(1): 157--163 MicroRNA pathways modulate polyglutamine-induced neurodegeneration. [FBrf0192284] Thompson and Cohen, 2006, Cell 126(4): 767--774 The hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila. [FBrf0193861] Brennecke et al., 2003, Cell 113(1): 25--36 bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. [FBrf0158764]

Allele Dmel\banD.Scer\UAS.T:Avic\GFP-EGFP

Allele Dmel\ban^{D.Scer\UAS.T:Avic\GFP-EGFP}