Allele Scer\GAL4^kirre-rP298

General Information
Symbol	Scer\GAL4^kirre-rP298	Species	S. cerevisiae
Name		FlyBase ID	FBal0147459
Feature type	allele	Associated gene	Scer\GAL4

Allele class
Mutagen	gene conversion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	gene conversion (Menon and Chia, 2001)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{PZ}rP298 (Menon and Chia, 2001)
Nature of the lesion	Statement Reference Generated from P{PZ}rP298 by gene conversion. (Menon and Chia, 2001)
Caused by insertion	P{GAL4}rP298 (Menon and Chia, 2001, Chen et al., 2003, Menon et al., 2005, Bazigou et al., 2007, Bazigou et al., 2007, Kim et al., 2007, Dubois et al., 2007, Balagopalan et al., 2006, Rotkopf et al., 2011, Enriquez et al., 2010, Sens et al., 2010, Bahri et al., 2009, Schafer et al., 2007, Bulchand et al., 2010, Jin et al., 2011, Nguyen et al., 2007, Dottermusch-Heidel et al., 2012, Haralalka et al., 2011, Susic-Jung et al., 2012, Duan et al., 2012)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	embryonic myoblast, with Arf51F^{T27N.Scer\UAS} (Chen et al., 2003) mesothoracic dorsal acute muscle 3, with Ubx^Ia.Scer\UAS (Enriquez et al., 2010) metathoracic dorsal acute muscle 3, with Ubx^Ia.Scer\UAS (Enriquez et al., 2010)
Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
NOT Suppressor of
Statement Reference Scer\GAL4^kirre-rP298/mib1^Scer\UAS.cWa is a non-suppressor of embryonic/larval somatic muscle \| embryonic stage 16 phenotype of mib2¹ (Nguyen et al., 2007) Scer\GAL4^kirre-rP298/neur^Scer\UAS.cPa is a non-suppressor of embryonic/larval somatic muscle \| embryonic stage 16 phenotype of mib2¹ (Nguyen et al., 2007) Scer\GAL4^kirre-rP298/Rac1^V12.Scer\UAS is a non-suppressor of embryonic myoblast phenotype of mbc^D11.2 (Haralalka et al., 2011)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	rols^7.Scer\UAS/Scer\GAL4^kirre-rP298 rescues Df(3L)BK9 (Menon and Chia, 2001) rols^7.Scer\UAS/Scer\GAL4^kirre-rP298 rescues rols^1728-20L (Haralalka et al., 2011) Scer\GAL4^kirre-rP298/mib2^Scer\UAS.cNa rescues mib2¹ (Nguyen et al., 2007)
Partially rescues	Scer\GAL4^kirre-rP298/mib2^{ΔRF.Scer\UAS} partially rescues mib2¹ (Nguyen et al., 2007) Scer\GAL4^kirre-rP298/siz^{Scer\UAS.T:Ivir\HA1} partially rescues siz^C1-28 (Dottermusch-Heidel et al., 2012)
Fails to rescue	blow^Scer\UAS.cJa/Scer\GAL4^kirre-rP298 fails to rescue blow¹ (Jin et al., 2011) mbc^{Scer\UAS.T:Ivir\HA1}/Scer\GAL4^kirre-rP298 fails to rescue mbc^D11.2 (Balagopalan et al., 2006, Haralalka et al., 2011) Pak3^{Scer\UAS.T:SV5\V5}/Scer\GAL4^kirre-rP298 fails to rescue Pak3^del (Duan et al., 2012) Scer\GAL4^kirre-rP298/WASp^Scer\UAS.cBa fails to rescue Df(3R)3450/WASp^3D3-035 (Schafer et al., 2007)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Expression pattern confirmed as similar to original enhancer trap (P{PZ}rP298). (Menon and Chia, 2001)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Scer\GAL4^kirre-rP298
Name Synonym
Secondary FlyBase IDs

References ( 20 )
Research paper	Dottermusch-Heidel et al., 2012, Dev. Biol. 368(1): 18--27 The Arf-GEF Schizo/Loner regulates N-cadherin to induce fusion competence of Drosophila myoblasts. [FBrf0218661] Duan et al., 2012, J. Cell Biol. 199(1): 169--185 Group I PAKs function downstream of Rac to promote podosome invasion during myoblast fusion in vivo. [FBrf0219579] Susic-Jung et al., 2012, Dev. Biol. 370(1): 86--97 Multinucleated smooth muscles and mononucleated as well as multinucleated striated muscles develop during establishment of the male reproductive organs of Drosophila melanogaster. [FBrf0219326] Haralalka et al., 2011, Development 138(8): 1551--1562 Asymmetric Mbc, active Rac1 and F-actin foci in the fusion-competent myoblasts during myoblast fusion in Drosophila. [FBrf0213340] Jin et al., 2011, Dev. Cell 20(5): 623--638 Competition between Blown Fuse and WASP for WIP Binding Regulates the Dynamics of WASP-Dependent Actin Polymerization In Vivo. [FBrf0213682] Rotkopf et al., 2011, Development 138(13): 2729--2739 The WASp-based actin polymerization machinery is required in somatic support cells for spermatid maturation and release. [FBrf0213892] Bulchand et al., 2010, J. Cell Sci. 123(16): 2697--2707 Muscle wasted: a novel component of the Drosophila histone locus body required for muscle integrity. [FBrf0211459] Enriquez et al., 2010, Development 137(3): 457--466 Multi-step control of muscle diversity by Hox proteins in the Drosophila embryo. [FBrf0209729] Sens et al., 2010, J. Cell Biol. 191(5): 1013--1027 An invasive podosome-like structure promotes fusion pore formation during myoblast fusion. [FBrf0212349] Bahri et al., 2009, Dev. Biol. 325(1): 15--23 The Drosophila homologue of Arf-GAP GIT1, dGIT, is required for proper muscle morphogenesis and guidance during embryogenesis . [FBrf0207889] Bazigou et al., 2007, Cell 128(5): 961--975 Anterograde jelly belly and Alk receptor tyrosine kinase signaling mediates retinal axon targeting in Drosophila. [FBrf0192674] Dubois et al., 2007, Development 134(24): 4347--4355 collier transcription in a single Drosophila muscle lineage: the combinatorial control of muscle identity. [FBrf0200492] Kim et al., 2007, Dev. Cell 12(4): 571--586 A critical function for the actin cytoskeleton in targeted exocytosis of prefusion vesicles during myoblast fusion. [FBrf0202337] Nguyen et al., 2007, J. Cell Biol. 179(2): 219--227 Drosophila mind bomb2 is required for maintaining muscle integrity and survival. [FBrf0201389] Schafer et al., 2007, Dev. Biol. 304(2): 664--674 The Wiskott-Aldrich syndrome protein (WASP) is essential for myoblast fusion in Drosophila. [FBrf0194614] Balagopalan et al., 2006, Mol. Cell. Biol. 26(24): 9442--9455 The CDM superfamily protein MBC directs myoblast fusion through a mechanism that requires phosphatidylinositol 3,4,5-triphosphate binding but is independent of direct interaction with DCrk. [FBrf0194774] Menon et al., 2005, J. Cell Biol. 169(6): 909--920 A positive feedback loop between dumbfounded and rolling pebbles leads to myotube enlargement in Drosophila. [FBrf0187819] Chen et al., 2003, Cell 114(6): 751--762 Control of myoblast fusion by a guanine nucleotide exchange factor, loner, and its effector ARF6. [FBrf0161992] Menon and Chia, 2001, Dev. Cell 1(5): 691--703 Drosophila rolling pebbles: a multidomain protein required for myoblast fusion that recruits D-Titin in response to the myoblast attractant Dumbfounded. [FBrf0141462]
Supplementary material	Bazigou et al., 2007, Cell 128(5): Supplemental Data. Anterograde Jelly belly and Alk receptor tyrosine kinase signaling mediates retinal axon targeting in Drosophila. [FBrf0199314]

Allele Scer\GAL4kirre-rP298

Allele Scer\GAL4^kirre-rP298