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General Information
Symbol
Dmel\SlikKG04837
Species
D. melanogaster
Name
FlyBase ID
FBal0147680
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The P{SUPor-P} insertion is within the first intron of slik.

Insertion components
P{SUPor-P}SlikKG04837
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

wing & epithelial cell

wing & epithelial cell | ectopic

Detailed Description
Statement
Reference

In mutant wings, the columnar epithelium is abnormally thin. Many cells lose their capacity to remain intergrated in the epithelium and are extruded basally to form a disorganised mass. Many apoptotic cells are seen below the epithelial layer. Some of the extruded cells are alive and appear mesenchymal, having lost their polarized epithelial character. These cells produce F-actin rich filopodia and appear to acquire motile behaviour.

Homozygous larvae show a growth defect phenotype. Mutants are delayed with respect to growth and developmental timing. After 5 days the largest mutant larvae grow to about one-third of the size of controls. Relatively few progress as far as third instar larvae. Some larvae have an abnormally long lifespan. More than 5% of mutant larvae remain alive for 15 days and some reach a relatively normal third-instar larval size. slik1/slikKG04837 animals are viable, 90% of expected flies survive. slikKG04837/slik1 flies how a 15% decrease in viability. Nearly 40% of the wings in the surviving flies have defects. Most show curvature of the wing blade surface or small isolated vesicles. However 30% of affected wings show a stronger phenotype characterised by accumulation of vesicles and reduction in wing size. These defects correlate with an increased level of apoptosis in wing discs.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Phenotype Manifest In
Enhanced by
Statement
Reference

SlikKG04837/Slik1 has wing phenotype, enhanceable by Raf7

Additional Comments
Genetic Interactions
Statement
Reference

When heterozygous phl7 is added to slik1/slikKG04837 animals about 40% of animals survive(as opposed to 90%) and the penetrance of the wing phenotype is increased from 11% to almost 100%. The number of apoptotic cells seen also increases.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
Plkk1KG04837
SlikKG04837
slikKG04837
Name Synonyms
Secondary FlyBase IDs
    References (4)