Allele Dmel\InR^ex15

General Information
Symbol	Dmel\InR^ex15	Species	D. melanogaster
Name		FlyBase ID	FBal0147836
Feature type	allele	Associated gene	Dmel\InR
Also Known As	dinr^ex15

Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective \| somatic clone (Song et al., 2003, Mann et al., 2012)
Phenotype Manifest In
	embryonic/larval optic lobe \| somatic clone (Song et al., 2003) lamina neuropil \| somatic clone (Song et al., 2003) medulla \| somatic clone (Song et al., 2003) medulla anlage \| somatic clone (Song et al., 2003) photoreceptor cell \| somatic clone (Mann et al., 2012)
Detailed Description
	Statement Reference Single photoreceptors mutant for InR[ex15] survive, but axons have an altered morphology and the axonal process is very thin compared with wild type axons. All analysed R8 photoreceptors correctly target the M3 layer. (Mann et al., 2012) InR^ex15 mutants show no defects in opsin regulation. (Mikeladze-Dvali et al., 2005) In mosaic larvae in which homozygous clones have been induced in the eye, photoreceptor cell axons project normally through the optic stalk but fail to target the optic lobe properly. The axons cross and terminate prematurely, resulting in gaps and densely packed regions in the lamina. In the medulla, projections fail to form the staggered projections seen in the wild type and the growth cones terminate in thick blunt ends. The pattern of R7 and R8 projections in the medulla shows defects in mosaic adults in which homozygous clones have been induced in the eye; crossing of fibres and gaps in the R7 layer are seen. Heterozygotes have normal photoreceptor cell projections in the medulla. (Song et al., 2003)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference InR[+]/InR^ex15 is a suppressor of neuroanatomy defective phenotype of Scer\GAL4^GMR.PF, gogo^Scer\UAS.T1 (Mann et al., 2012)
Other
Statement Reference InR[+]/InR^ex15, dock⁰⁴⁷²³ has neuroanatomy defective phenotype (Song et al., 2003) InR[+]/InR^ex15, dock¹³⁴²¹ has neuroanatomy defective phenotype (Song et al., 2003) InR^ex15, dock⁰⁴⁷²³ has neuroanatomy defective phenotype (Song et al., 2003) InR^ex15, dock¹³⁴²¹ has neuroanatomy defective phenotype (Song et al., 2003)
Phenotype Manifest In
Suppressor of
Statement Reference InR[+]/InR^ex15 is a suppressor of medulla layer M1 phenotype of Scer\GAL4^GMR.PF, gogo^Scer\UAS.T1 (Mann et al., 2012) InR[+]/InR^ex15 is a suppressor of photoreceptor cell R8 phenotype of Scer\GAL4^GMR.PF, gogo^Scer\UAS.T1 (Mann et al., 2012)
Other
Statement Reference InR[+]/InR^ex15, dock⁰⁴⁷²³ has medulla anlage phenotype (Song et al., 2003) InR[+]/InR^ex15, dock⁰⁴⁷²³ has medulla phenotype (Song et al., 2003) InR[+]/InR^ex15, dock¹³⁴²¹ has medulla anlage phenotype (Song et al., 2003) InR[+]/InR^ex15, dock¹³⁴²¹ has medulla phenotype (Song et al., 2003) InR^ex15, dock⁰⁴⁷²³ has medulla anlage phenotype (Song et al., 2003) InR^ex15, dock⁰⁴⁷²³ has medulla phenotype (Song et al., 2003) InR^ex15, dock¹³⁴²¹ has medulla anlage phenotype (Song et al., 2003) InR^ex15, dock¹³⁴²¹ has medulla phenotype (Song et al., 2003)
Additional Comments
Genetic Interactions
Statement Reference One copy of InR[ex15] suppresses the R8 photoreceptor phenotype seen when gogo[Scer\UAS.T1] is expressed under the control of Scer\GAL4[GMR.PF]. 12% of R8 axons form blob-like structures at the M1 layer. (Mann et al., 2012) dock⁰⁴⁷²³/+ ; InR^ex15/+ double heterozygotes show defects in photoreceptor axon projections in the medulla; gaps in the R7 terminal array and uninnervated areas are seen. These defects are seen in larvae and adults. dock¹³⁴²¹/+ ; InR^ex15/+ double heterozygotes show defects in photoreceptor axon projections in the medulla; gaps in the R7 terminal array and uninnervated areas are seen. These defects are seen in larvae and adults. No obvious defects in photoreceptor axon projections in the medulla are seen in chico¹/+ ; InR^ex15/+ double heterozygous adults. (Song et al., 2003)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	dinr^ex15 (Song et al., 2003, Mann et al., 2012) DInR^ex15 (Mikeladze-Dvali et al., 2005) InR^ex15 (Yu et al., 2009)
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Mann et al., 2012, Development 139(4): 760--771 A putative tyrosine phosphorylation site of the cell surface receptor Golden goal is involved in synaptic layer selection in the visual system. [FBrf0217291] Yu et al., 2009, Development 136(9): 1497--1507 Dicer-1-dependent Dacapo suppression acts downstream of Insulin receptor in regulating cell division of Drosophila germline stem cells. [FBrf0207811] Mikeladze-Dvali et al., 2005, Cell 122(5): 775--787 The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors. [FBrf0187233] Song et al., 2003, Science 300(5618): 502--505 Axons guided by insulin receptor in Drosophila visual system. [FBrf0159327]

Allele Dmel\InRex15

Allele Dmel\InR^ex15