|Feature type||allele||Associated gene||Dmel\InR|
|Also Known As||dinrex15|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Phenotype Manifest In|
Single photoreceptors mutant for InR[ex15] survive, but axons have an altered morphology and the axonal process is very thin compared with wild type axons. All analysed R8 photoreceptors correctly target the M3 layer.
In mosaic larvae in which homozygous clones have been induced in the eye, photoreceptor cell axons project normally through the optic stalk but fail to target the optic lobe properly. The axons cross and terminate prematurely, resulting in gaps and densely packed regions in the lamina. In the medulla, projections fail to form the staggered projections seen in the wild type and the growth cones terminate in thick blunt ends. The pattern of R7 and R8 projections in the medulla shows defects in mosaic adults in which homozygous clones have been induced in the eye; crossing of fibres and gaps in the R7 layer are seen. Heterozygotes have normal photoreceptor cell projections in the medulla.
|Phenotype Manifest In|
One copy of InR[ex15] suppresses the R8 photoreceptor phenotype seen when gogo[Scer\UAS.T1] is expressed under the control of Scer\GAL4[GMR.PF]. 12% of R8 axons form blob-like structures at the M1 layer.
dock04723/+ ; InRex15/+ double heterozygotes show defects in photoreceptor axon projections in the medulla; gaps in the R7 terminal array and uninnervated areas are seen. These defects are seen in larvae and adults. dock13421/+ ; InRex15/+ double heterozygotes show defects in photoreceptor axon projections in the medulla; gaps in the R7 terminal array and uninnervated areas are seen. These defects are seen in larvae and adults. No obvious defects in photoreceptor axon projections in the medulla are seen in chico1/+ ; InRex15/+ double heterozygous adults.
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 3 )|
|Secondary FlyBase IDs|
|References ( 4 )|