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General Information
Symbol
Hsap\ARQ52AF-1.UAS
Species
H. sapiens
Name
FlyBase ID
FBal0147859
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of a truncated human androgen receptor (Hsap\AR) lacking the C-terminal 229 codons (which includes the ligand binding domain), in which the polyQ repeats are expanded to from 20(wild-type) to 52.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
is exacerbated by hoipGS7164
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Hsap\ARQ52AF-1.Scer\UAS under the control of Scer\GAL4GMR.PF leads to neurodegeneration and the development of a rough eye phenotype.

Animals expressing Hsap\ARQ52AF-1.Scer\UAS under the control of Scer\GAL4GMR.PY have severely disrupted eye morphology.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

The presence of hoipGS7164 significantly enhances the neurodegeneration and rough eye phenotype seen upon expression of Hsap\ARQ52AF-1.Scer\UAS under the control of Scer\GAL4GMR.PF. The numbers of rhabdomeres decreases significantly compared to single mutant controls.

The presence of nop5Scer\UAS.cMa significantly enhances the neurodegeneration and rough eye phenotype seen upon expression of Hsap\ARQ52AF-1.Scer\UAS under the control of Scer\GAL4GMR.PF. The numbers of rhabdomeres decreases significantly compared to single mutant controls.

The presence of Nop56Scer\UAS.cMa significantly enhances the neurodegeneration and rough eye phenotype seen upon expression of Hsap\ARQ52AF-1.Scer\UAS under the control of Scer\GAL4GMR.PF. The numbers of rhabdomeres decreases significantly compared to single mutant controls.

Complementation and Rescue Data
Partially rescued by
Comments

The rough eye phenotype of Hsap\ARQ52AF-1.Scer\UAS; Scer\GAL4GMR.PY animals is partially suppressed by the co-expression of (Hsap\ARAF-2.Scer\UAS). This suppression is prevented by treatment of the animals with the androgen receptor ligand dihydroxytestosterone (DHT).

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Hsap\ARQ52AF-1.Scer\UAS
Hsap\ARQ52AF-1.UAS
Name Synonyms
Secondary FlyBase IDs
    References (3)