FlyBase Allele Report: Dmel\Dscam1[21]

Single cell analysis reveals a failure of Dscam1²¹ mushroom body clone neurons to extend their axon branches dorsally and instead develop parallel horizontal branches.

(Goyal et al., 2019)

Dscam1²³/Dscam1²¹ transheterozygous embryos show defects in dendritogenesis in the embryonic aCC motoneurons (misplacement of primary branches) compared to controls. No gross morphology defects are observed in the MP1 neurons at early embryonic stage.

(Kamiyama et al., 2015)

Dscam²¹ homozygous mutant third instar larvae show a mild but statistically significant increase in the proportion of dorsal midline ddaC dendrite length that is enclosed within the epidermis rather than attached to the ECM. The enclosed dendrite segments are often in the middle of stabilized dendritic branches. Most of the dendritic crossings seen in these mutants are between two dendrites that both contact the ECM and thus the dendrites are making contact.

(Han et al., 2012)

Most Dscam1²¹/Dscam1^B17-1 mutants die at early larval stages, with the remainder dying before eclosion, and dendritic arborization neurons exhibit self-avoidance defects.

Surviving adults of Dscam1²¹/Dscam1^B17-1 mutants expressing Dscam1^{B1.4.2-6.18-9.22-17.1}, Dscam1^{B2.4.2-6.18-9.22-17.2}, Dscam1^{C1.4.2-6.14-9.24-17.1}, Dscam1^{C2.4.2-6.14-9.24-17.2}, both Dscam1^{B2.4.2-6.18-9.22-17.2} and Dscam1^{C1.4.2-6.14-9.24-17.1}, or both Dscam1^{B1.4.2-6.18-9.22-17.1} and Dscam1^{C2.4.2-6.14-9.24-17.2}, are largely immobile, have unexpanded wings, and die a few days after eclosion. The mushroom bodies in these adults exhibit abnormal morphology, with either no lobes or only one lobe projecting medially or dorsally.

(Huang et al., 2011)

Mutants show increased overlap and fasciculation of self-dendrites among dendritic arborization neurons in the larval body wall.

(Hattori et al., 2009)

Less than 25% of Dscam²¹/Dscam²³ larvae survive to late pupal stages.

Dscam²¹/Dscam²³ embryos show defects in the organisation of the central nervous system, showing severely disrupted longitudinal tracts and some aberrant midline crossing.

(Hattori et al., 2007)

Class I da neurons show defects in self-avoidance in Dscam²¹/Dscam²³ larvae, such that in contrast to wild type, class I dendrites from the same cell overlap extensively and fasciculate in the mutant animals. Arbors of each cell project to the same general location as in wild type, but there are significant gaps in territory coverage.

Class IV da neurons in Dscam²¹/Dscam²³ larvae show self-avoidance defects, but the tiling pattern is not obviously disrupted compared to wild type.

(Matthews et al., 2007)

Dscam²¹ posterior Dorsocentral (pDc), anterior Scutellar (aSc) and posterior Scutellar (pSc) neuron clones enter the thoracic ganglion at the correct position but are unable to correctly target axonal branches and fail to elaborate any arbors. These neurons are able to form axonal branches but these remain clustered in a small bolus around a presumptive decision point. This phenotype is 100% penetrant for all tested neuron clones.

(Chen et al., 2006)

Small clones of Dscam²¹ cells induced in the mushroom body at the early third instar and then examined 24-36 hours later are seen as multiple fascicles in 15% of cases (in contrast to wild-type control clones which form single fascicles). Defects in branching are also seen in the mushroom body lobes; the mutant clones still form two distinct branches, but the branches fail to segregate dorsally and medially in 68% of cases.

(Zhan et al., 2004)

Dscam²¹ mutant antennal olfactory receptor neurons often form discrete dense aggregates when they terminate in the glomeruli (in contrast to wild type, where the axons elaborate processes that extend throughout the glomeruli). Or47a-expressing olfactory receptor neurons (ORNs) that are mutant for Dscam²¹ show marked mis-targeting of axons in the antennal lobe, often failing to project to the normal target (glomerulus DM3) and instead innervating abnormal locations on the ipsilateral side. P{GAL4}GH298-expressing ORNs that are mutant for Dscam²¹ often fail to project to their normal target (the V glomerulus), innervating abnormal locations on the ipsilateral side. In 20% of cases none of the mutant fibres innervate the correct target. Single Dscam²¹ mutant Or47a-expressing ORNs exit the antennal nerve and often terminate in abnormal locations between glomeruli. Mutant terminals that do reach the appropriate glomerulus fail to elaborate the network of thin arbors characteristic of wild-type terminals. Single Dscam²¹ mutant P{GAL4}GH298-expressing ORNs show both ectopic targeting and defects in the morphology of terminals within the V glomerulus. Or22a-expressing and Or23a-expressing Dscam²¹ mutant ORNs target normally to the correct glomerulus, although they show a marked reduction in branches to the contralateral antennal lobe. Or47b-expressing Dscam²¹ mutant ORNs show mistargeting to more dorsal regions of the antennal lobe than the normal target (the VA1 l/m glomerulus) and also targeting defects in the contralateral lobe. Or46a-expressing Dscam²¹ mutant ORNs frequently terminate upon entering the ventral central nervous system before reaching the antennal lobe, either immediately prior to entering the suboesophageal ganglion or upon exiting it, just ventral to the antennal lobe.

(Hummel et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Dscam1²¹/Dscam1[+], Spt-I^B2 has abnormal neuroanatomy | adult stage phenotype, enhanceable by lace[+]/lace²

(Goyal et al., 2019)

Suppressed by

Statement

Reference

Dscam1²¹/Dscam1^B17-1 has lethal - all die before end of P-stage phenotype, suppressible | partially by Hsap\DSCAML1^Dscam1.WT

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1 has lethal - all die before end of P-stage phenotype, suppressible | partially by Hsap\DSCAM^Dscam1.WT/Dscam1^{C1.4.2-6.14-9.24-17.1}

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1 has lethal - all die before end of P-stage phenotype, suppressible | partially by Hsap\DSCAM^Dscam1.WT/Dscam1^{B2.4.2-6.18-9.22-17.2}

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1 has lethal - all die before end of P-stage phenotype, suppressible | partially by Hsap\DSCAM^Dscam1.WT/Dscam1^{C2.4.2-6.14-9.24-17.2}

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1 has lethal - all die before end of P-stage phenotype, suppressible | partially by Hsap\DSCAML1^Dscam1.WT/Dscam1^{B2.4.2-6.18-9.22-17.2}

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1 has lethal - all die before end of P-stage phenotype, suppressible | partially by Hsap\DSCAML1^Dscam1.WT/Dscam1^{C2.4.2-6.14-9.24-17.2}

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1 has abnormal neuroanatomy | larval stage phenotype, suppressible | partially by Hsap\DSCAML1^Dscam1.WT

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1 has lethal - all die before end of P-stage phenotype, suppressible | partially by Hsap\DSCAM^Dscam1.WT

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1 has abnormal neuroanatomy | larval stage phenotype, suppressible | partially by Hsap\DSCAM^Dscam1.WT

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1 has lethal - all die before end of P-stage phenotype, suppressible | partially by Hsap\DSCAML1^Dscam1.WT/Hsap\DSCAM^Dscam1.WT

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1 has lethal - all die before end of P-stage phenotype, suppressible | partially by Hsap\DSCAML1^Dscam1.WT/Dscam1^{B1.4.2-6.18-9.22-17.1}

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1 has lethal - all die before end of P-stage phenotype, suppressible | partially by Hsap\DSCAML1^Dscam1.WT/Dscam1^{C1.4.2-6.14-9.24-17.1}

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1 has lethal - all die before end of P-stage phenotype, suppressible | partially by Hsap\DSCAM^Dscam1.WT/Dscam1^{B1.4.2-6.18-9.22-17.1}

(Huang et al., 2011)

NOT suppressed by

Statement

Reference

Dscam1²¹/Dscam1^B17-1 has lethal - all die before end of P-stage phenotype, non-suppressible by Hsap\DSCAM^T.Dscam1.GFP

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1 has lethal - all die before end of P-stage phenotype, non-suppressible by Hsap\DSCAML1^T.Dscam1.GFP

(Huang et al., 2011)

NOT Enhancer of

Statement

Reference

Dscam1²¹/Dscam1[+] is a non-enhancer of abnormal neuroanatomy | dominant | adult stage phenotype of tap^Gal4

(Yuan et al., 2016)

Other

Statement

Reference

Dscam1²¹/Dscam1[+], Spt-I^B2 has abnormal neuroanatomy | adult stage phenotype

(Goyal et al., 2019)

Dscam1²¹/Dscam1[+], Pak^6-2 has abnormal neuroanatomy | embryonic stage phenotype

(Kamiyama et al., 2015)

Dscam1²¹/Dscam1[+], dock⁰⁴⁷²³ has abnormal neuroanatomy | embryonic stage phenotype

(Kamiyama et al., 2015)

Dscam1²¹/Dscam1^B17-1, Hsap\DSCAM^Dscam1.WT has short lived phenotype

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1, Hsap\DSCAM^Dscam1.WT has abnormal neuroanatomy | adult stage phenotype

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1, Hsap\DSCAML1^Dscam1.WT has abnormal locomotor behavior | adult stage phenotype

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1, Hsap\DSCAML1^Dscam1.WT has visible phenotype

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1, Hsap\DSCAML1^Dscam1.WT has short lived phenotype

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1, Hsap\DSCAML1^Dscam1.WT has abnormal neuroanatomy | adult stage phenotype

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1, Hsap\DSCAM^Dscam1.WT has abnormal locomotor behavior | adult stage phenotype

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1, Hsap\DSCAM^Dscam1.WT has visible phenotype

(Huang et al., 2011)

Phenotype Manifest In

Enhanced by

Statement

Reference

Dscam1²¹/Dscam1[+], Spt-I^B2 has lobe system of adult mushroom body phenotype, enhanceable by lace[+]/lace²

(Goyal et al., 2019)

Dscam1²¹/Dscam1[+], Spt-I^B2 has adult olfactory receptor neuron Or47a phenotype, enhanceable by lace[+]/lace²

(Goyal et al., 2019)

Dscam1²¹/Dscam1[+], Spt-I^B2 has axon | adult stage phenotype, enhanceable by lace[+]/lace²

(Goyal et al., 2019)

Suppressed by

Statement

Reference

Dscam1²¹/Dscam1^B17-1 has dendritic arborizing neuron | larval stage phenotype, suppressible | partially by Hsap\DSCAML1^Dscam1.WT

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1 has dendritic arborizing neuron | larval stage phenotype, suppressible | partially by Hsap\DSCAM^Dscam1.WT

(Huang et al., 2011)

NOT Enhancer of

Statement

Reference

Dscam1²¹/Dscam1[+] is a non-enhancer of adult mushroom body beta-lobe | adult stage phenotype of tap^Gal4

(Yuan et al., 2016)

Other

Statement

Reference

Dscam1²¹/Dscam1[+], Spt-I^B2 has lobe system of adult mushroom body phenotype

(Goyal et al., 2019)

Dscam1²¹/Dscam1[+], Spt-I^B2 has adult olfactory receptor neuron Or47a phenotype

(Goyal et al., 2019)

Dscam1²¹/Dscam1[+], Spt-I^B2 has axon | adult stage phenotype

(Goyal et al., 2019)

Dscam1²¹/Dscam1[+], Pak^6-2 has aCC neuron | embryonic stage phenotype

(Kamiyama et al., 2015)

Dscam1²¹/Dscam1[+], Pak^6-2 has dendrite | embryonic stage phenotype

(Kamiyama et al., 2015)

Dscam1²¹/Dscam1[+], dock⁰⁴⁷²³ has aCC neuron | embryonic stage phenotype

(Kamiyama et al., 2015)

Dscam1²¹/Dscam1[+], dock⁰⁴⁷²³ has dendrite | embryonic stage phenotype

(Kamiyama et al., 2015)

Dscam1²¹/Dscam1^B17-1, Hsap\DSCAML1^Dscam1.WT has wing | adult stage phenotype

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1, Hsap\DSCAML1^Dscam1.WT has adult mushroom body | adult stage phenotype

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1, Hsap\DSCAM^Dscam1.WT has wing | adult stage phenotype

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1, Hsap\DSCAM^Dscam1.WT has adult mushroom body | adult stage phenotype

(Huang et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

Spt-I^B2, Dscam1²¹, lace² triple heterozygous adults show a moderate prevalence of mushroom body defects, namely a "lost-lobe" phenotype; Spt-I^B2, Dscam1²¹ double heterozygous adults do not show this defect.

Spt-I^B2, Dscam1²¹ double heterozygous adults also show Or47a neurons with axonal mistargeting defects; this defect is somewhat enhanced by additional lace² heterozygosity.

(Goyal et al., 2019)

Dscam1²¹/+ does not significantly enhance frequency of mushroom body beta lobe axon overgrowth defects in tap^Gal4/+ brains.

(Yuan et al., 2016)

Pak^6-2;Dscam1²¹ as well as dock⁰⁴⁷²³;Dscam1²¹ double heterozygous mutants display defects in dendritogenesis in the embryonic aCC motoneurons (decreased number of dendritic tips), which are not seen in either of the single heterozygotes.

(Kamiyama et al., 2015)

Xenogenetic Interactions

Statement

Reference

Expression of both Hsap\DSCAML1^Dscam1.WT and Hsap\DSCAM^Dscam1.WT, or both Hsap\DSCAM^Dscam1.WT and Dscam1^{B1.4.2-6.18-9.22-17.1}, or both Hsap\DSCAM^Dscam1.WT and Dscam1^{C1.4.2-6.14-9.24-17.1}, or both Hsap\DSCAML1^Dscam1.WT and Dscam1^{B1.4.2-6.18-9.22-17.1}, or both Hsap\DSCAML1^Dscam1.WT and Dscam1^{C1.4.2-6.14-9.24-17.1}, partially rescues the lethality of Dscam1²¹/Dscam1^B17-1 mutants, with an increased proportion of mutants developing to late pupal stage, and a small number of adults emerging.

Expression of Hsap\DSCAML1^Dscam1.WT or Hsap\DSCAM^Dscam1.WT largely rescues the dendritic arborization neuron self-avoidance defects, and partially rescues the lethality of Dscam1²¹/Dscam1^B17-1 mutants, with an increased proportion of mutants developing to late pupal stage, and a small number of adults emerging. The majority of these adults are immobile and have unexpanded wings, and die a few days after eclosion. The mushroom bodies in these adults exhibit abnormal morphology, with either no lobes or only one lobe projecting medially or dorsally.

Expression of Hsap\DSCAM^{T.Dscam1.T:Avic\GFP} or Hsap\DSCAML1^{T.Dscam1.T:Avic\GFP} fails to rescue the larval lethality of Dscam1²¹/Dscam1^B17-1 mutants.

Expression of both Hsap\DSCAM^Dscam1.WT and Dscam1^{B2.4.2-6.18-9.22-17.2}, or both Hsap\DSCAM^Dscam1.WT and Dscam1^{C2.4.2-6.14-9.24-17.2}, or both Hsap\DSCAML1^Dscam1.WT and Dscam1^{B2.4.2-6.18-9.22-17.2}, or both Hsap\DSCAML1^Dscam1.WT and Dscam1^{C2.4.2-6.14-9.24-17.2}, substantially rescues the lethality of Dscam1²¹/Dscam1^B17-1 mutants, with a majority of mutants developing to late pupal stages.

(Huang et al., 2011)

Complementation and Rescue Data

Rescued by

Dscam1²¹/Dscam1²³ is rescued by Dscam1^{exon17.2.UAS.GFP}/Scer\GAL4^GMR23E04/Scer\GAL4^eve.RN2

(Kamiyama et al., 2015)

Dscam1²⁰/Dscam1²¹ is rescued by Dscam1^{+tCH321-22M14}

(Venken et al., 2009)

Dscam1²¹/Dscam1²³ is rescued by Dscam1^{4.3-6.36-9.25-17.1}/Scer\GAL4²²¹/Scer\GAL4²²¹

(Matthews et al., 2007)

Partially rescued by

Dscam1²¹/Dscam1^B17-1 is partially rescued by Dscam1^{B1.4.2-6.18-9.22-17.1}

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1 is partially rescued by Dscam1^{B2.4.2-6.18-9.22-17.2}

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1 is partially rescued by Dscam1^{C1.4.2-6.14-9.24-17.1}

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1 is partially rescued by Dscam1^{C2.4.2-6.14-9.24-17.2}

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1 is partially rescued by Dscam1^{B2.4.2-6.18-9.22-17.2}/Dscam1^{C1.4.2-6.14-9.24-17.1}

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1 is partially rescued by Dscam1^{C2.4.2-6.14-9.24-17.2}/Dscam1^{B1.4.2-6.18-9.22-17.1}

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1 is partially rescued by Dscam1^{A1.4.3-6.36-9.25-17.1}

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1 is partially rescued by Dscam1^{A2.4.3-6.36-9.25-17.2}

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1 is partially rescued by Dscam1^{C1.4.2-6.14-9.24-17.1}/Dscam1^{B1.4.2-6.18-9.22-17.1}

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1 is partially rescued by Dscam1^{B2.4.2-6.18-9.22-17.2}/Dscam1^{B1.4.2-6.18-9.22-17.1}

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1 is partially rescued by Dscam1^{B2.4.2-6.18-9.22-17.2}/Dscam1^{C2.4.2-6.14-9.24-17.2}

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1 is partially rescued by Dscam1^{C2.4.2-6.14-9.24-17.2}/Dscam1^{C1.4.2-6.14-9.24-17.1}

(Huang et al., 2011)

Dscam1²¹/Dscam1²³ is partially rescued by Dscam1^{UAS.1.30.30.1}/Scer\GAL4²²¹/Scer\GAL4²²¹

(Matthews et al., 2007)

Dscam1²¹/Dscam1²³ is partially rescued by Dscam^{1.30.30.2.cMa.Scer\UAS}/Scer\GAL4²²¹/Scer\GAL4²²¹

(Matthews et al., 2007)

Dscam1²¹ is partially rescued by Dscam1^{1.34.30.2.UAS}/Scer\GAL4^elav.PLu

(Chen et al., 2006)

Dscam1²¹ is partially rescued by Dscam1^{1.30.30.2.A.UAS}/Scer\GAL4^elav.PLu

(Chen et al., 2006)

Dscam1²¹ is partially rescued by Dscam1^7.6.19.2.UAS/Scer\GAL4^elav.PLu

(Chen et al., 2006)

Not rescued by

Dscam1²¹/Dscam1²³ is not rescued by Dscam1^{exon17.2.UAS.GFP}/Scer\GAL4^eve.RN2

(Kamiyama et al., 2015)

Dscam1²¹/Dscam1^B17-1 is not rescued by Dscam1^{C1T.4.2-6.14-9.24-17.1.GFP}

(Huang et al., 2011)

Dscam1²¹/Dscam1^B17-1 is not rescued by Dscam1^{C2T.4.2-6.14-9.24-17.2.GFP}

(Huang et al., 2011)

Dscam1²¹/Dscam1²³ is not rescued by Dscam1^{4.3-6.36-9.25-17.2}/Scer\GAL4²²¹/Scer\GAL4²²¹

(Matthews et al., 2007)

Comments

The dendritogenesis defects (reduced number of dendritic tips) in the embryonic aCC motoneurons characteristic for Dscam1²³/Dscam1²¹ transheterozygotes cannot be rescued by expression of Dscam1^{exon17.2.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^eve.RN2 but is fully rescued when both Scer\GAL4^eve.RN2 and Scer\GAL4^GMR23E04 driver are used simultaneously - but only in the aCC that are associated with MP1 neurons expressing Dscam1^{exon17.2.Scer\UAS.T:Avic\GFP} (Scer\GAL4^GMR23E04 drives expression in a random half of all MP1 cells).

(Kamiyama et al., 2015)

Expression of Dscam1^{A1.4.3-6.36-9.25-17.1}, Dscam1^{A2.4.3-6.36-9.25-17.2}, Dscam1^{B1.4.2-6.18-9.22-17.1}, Dscam1^{B2.4.2-6.18-9.22-17.2}, or both Dscam1^{B1.4.2-6.18-9.22-17.1} and Dscam1^{C1.4.2-6.14-9.24-17.1}, or both Dscam1^{B2.4.2-6.18-9.22-17.2} and Dscam1^{C2.4.2-6.14-9.24-17.2}, partially rescues the lethality of Dscam1²¹/Dscam1^B17-1 mutants, with an increased proportion of mutants developing to late pupal stage, and a small number of adults emerging.

Expression of Dscam1^{C1.4.2-6.14-9.24-17.1} partially rescues the lethality of Dscam1²¹/Dscam1^B17-1 mutants, with an increased proportion of mutants developing to late pupal stage, and a small number of adults emerging; and largely rescues the dendritic arborization neuron self-avoidance defects of Dscam1²¹/Dscam1^B17-1 mutants.

Expression of both Dscam1^{B1.4.2-6.18-9.22-17.1} and Dscam1^{B2.4.2-6.18-9.22-17.2}, or both Dscam1^{B1.4.2-6.18-9.22-17.1} and Dscam1^{C2.4.2-6.14-9.24-17.2}, or both Dscam1^{C1.4.2-6.14-9.24-17.1} and Dscam1^{C2.4.2-6.14-9.24-17.2}, or both Dscam1^{B2.4.2-6.18-9.22-17.2} and Dscam1^{C1.4.2-6.14-9.24-17.1}, almost completely rescues the lethality of Dscam1²¹/Dscam1^B17-1 mutants, with most mutants developing to pupal stage.

Expression of Dscam1^{C2.4.2-6.14-9.24-17.2} partially rescues the lethality of Dscam1²¹/Dscam1^B17-1 mutants, with an increased proportion of mutants developing to late pupal stage, and a small number of adults emerging, but fails to rescue the dendritic arborization neuron self-avoidance defects of Dscam1²¹/Dscam1^B17-1 mutants.

Expression of Dscam1^{C1T.4.2-6.14-9.24-17.1.T:Avic\GFP} or Dscam1^{C2T.4.2-6.14-9.24-17.2.T:Avic\GFP} fails to rescue the larval lethality of Dscam1²¹/Dscam1^B17-1 mutants.

(Huang et al., 2011)

Expression of transgenes that encode different isoforms of Dscam, under the control of Scer\GAL4^elav.PLu, partially rescue the axonal targeting phenotype of Dscam²¹ mechanosensory clones. Both the Dscam^{1.34.30.2.Scer\UAS} and Dscam^{7.6.19.2.Scer\UAS} transgenes rescue primary axon extension posteriorly. Occasionally, Dscam^{1.30.30.2.A.Scer\UAS} rescues the proximal, anterior-extending secondary axonal branch and a distal ipsilateral branch.

(Chen et al., 2006)

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Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

DScam²¹

(Venken, 2006)

Dscam1²¹

(Yuan et al., 2016)

Dscam1^null

(Hattori et al., 2009)

Dscam²¹

(Goyal et al., 2019, Han et al., 2012, Huang et al., 2011, Venken et al., 2009, Hattori et al., 2007, Matthews et al., 2007, Chen et al., 2006, Zhu et al., 2006, Wang et al., 2004, Zhan et al., 2004)

Dscam^null

(Cvetkovska et al., 2013)

dscam1²¹

(Kamiyama et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (16)

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