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General Information
Symbol
Dmel\pathKG06640
Species
D. melanogaster
Name
FlyBase ID
FBal0148234
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

A P{SUPor-P} insertion within the first intron of the larger path transcription unit, path-RA.

Insertion components
P{SUPor-P}pathKG06640
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

pathKG06640, pathKG06640/pathdg50 or pathKG06640/Df(3L)BSC773 larvae show severe dendrite growth defects in the large C4da dendritic arbors.

pathKG06640 mutants are developmentally delayed, taking ~3 days longer than wild-type larvae to pupate. The wing discs of pathKG06640 third instar larvae are small when compared with similarly aged wild-type discs, but the extended mutant larval period allows discs to grow to roughly normal size by pupariation. The length of pupal development is not noticeably affected and resulting adults are markedly smaller than wild-type animals, are 40% lighter in weight, have wings with significant reductions in both cell number and size and eyes with small ommatidia. The salivary gland and the fat body are only modestly reduced. Additionally, pathKG06640 females fail to lay eggs.

pathKG06640/Df(3L)AC1 animals are even smaller than pathKG06640 homozygotes. These transheterozygotes are also developmentally delayed and female sterile.

Eyes in which many ommatidia are derived from pathKG06640 clones are indistinguishable in size from normal eyes.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
Suppressor of
Statement
Reference
Phenotype Manifest In
Suppressed by
Statement
Reference

pathKG06640 has wing phenotype, suppressible by CG1139GS10666

pathKG06640 has wing phenotype, suppressible by Tsc129/Tsc1[+]/gig[+]/gig192

Suppressor of
Statement
Reference

pathKG06640 is a suppressor of eye | somatic clone phenotype of gig192

Additional Comments
Genetic Interactions
Statement
Reference

The pathKG06640 reduced weight and small wing phenotypes are significantly rescued by expression of CG1139GS10666 under the control of Scer\GAL4arm.PS.

The growth and developmentally delayed phenotypes of pathKG06640 mutants are significantly rescued by the presence of combined heterozygous Tsc129 and gig192 mutations. About 10% of rescued females are able to lay a small number of eggs, some of which can develop into adult flies.

When clonal material in the eye is mutant for both gig192 and pathKG06640 in an otherwise heterozygous animal, the lethal effects of gig192 are suppressed, and about 10% of mutant animals, both males and females, eclose. Their eyes are smaller and bulge less than gig192 mutant eyes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by
Comments

Expression of pathScer\UAS.cGa under the control of the constitutive Scer\GAL4arm.PS driver significantly rescues the growth, developmental delay and female sterility mutant phenotypes of pathKG06640 homozygotes. Rescued flies are slightly smaller than controls.

Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (5)