Allele Dmel\sqz^ie

General Information
Symbol	Dmel\sqz^ie	Species	D. melanogaster
Name		FlyBase ID	FBal0150237
Feature type	allele	Associated gene	Dmel\sqz

Allele class	loss of function allele
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class	loss of function allele (Allan et al., 2003)
Mutagen	P-element activity (Allan et al., 2003)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	sqz^GAL4 (Allan et al., 2003)
Nature of the lesion	Statement Reference Imprecise excision of the P{GawB} element from sqz^GAL4 results in removal of part of the P-element and the second and third exon. (Allan et al., 2003)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| larval stage (with Df(3R)Dl-KX23) (Allan et al., 2003) neuroanatomy defective \| embryonic stage (Tsuji et al., 2008) neuroanatomy defective \| somatic clone (Komiyama and Luo, 2007)
Phenotype Manifest In
	adult antennal lobe projection neuron DM5 lPN \| somatic clone (Komiyama and Luo, 2007) EL neuron \| embryonic stage \| supernumerary (Tsuji et al., 2008) neuroblast NB3-3 \| embryonic stage (Tsuji et al., 2008)
Detailed Description
	Statement Reference The number of SE2 neurons is normal in sqz[ie] mutant animals. There are no SELK neurons observed in sqz[ie] mutant animals. (Losada-Pérez et al., 2010) Mutants show a delay in thoracic neuroblast 3-3 (NB3-3T) entering quiescence, and a corresponding increase in the number of EL neurons. (Tsuji et al., 2008) Targeting of DM5 lPN to the DM5 glomerulus fails in sqz[ie] homozygous somatic clones. (Komiyama and Luo, 2007) Penetrance is 100% for larval lethality in Df(3R)Dl-KX23/sqz^ie animals. (Allan et al., 2003)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 1 )
Bloomington	36497 w^*; P{UAS-sqz.A}7-3/CyO; P{neoFRT}82B sqz^ie/TM6B, Tb¹
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	sqz^- (Komiyama and Luo, 2007) sqz^ie (Baumgardt et al., 2007, Benito-Sipos et al., 2011, Tsuji et al., 2008, Baumgardt et al., 2009, Losada-Pérez et al., 2010)
Name Synonym
Secondary FlyBase IDs

References ( 8 )
Research paper	Benito-Sipos et al., 2011, Development 138(24): 5311--5320 Seven up acts as a temporal factor during two different stages of neuroblast 5-6 development. [FBrf0216799] Losada-Pérez et al., 2010, Mech. Dev. 127(9-12): 458--471 Lineage-unrelated neurons generated in different temporal windows and expressing different combinatorial codes can converge in the activation of the same terminal differentiation gene. [FBrf0212045] Baumgardt et al., 2009, Cell 139(5): 969--982 Neuronal subtype specification within a lineage by opposing temporal feed-forward loops. [FBrf0209429] Tsuji et al., 2008, Development 135(23): 3859--3869 Neuroblast entry into quiescence is regulated intrinsically by the combined action of spatial Hox proteins and temporal identity factors. [FBrf0206246] Baumgardt et al., 2007, PLoS Biol. 5(2): e37 Specification of neuronal identities by feedforward combinatorial coding. [FBrf0195184] Komiyama and Luo, 2007, Curr. Biol. 17(3): 278--285 Intrinsic control of precise dendritic targeting by an ensemble of transcription factors. [FBrf0195086] Miguel-Aliaga et al., 2004, Development 131(23): 5837--5848 Independent roles of the dachshund and eyes absent genes in BMP signaling, axon pathfinding and neuronal specification. [FBrf0180178]
Supplementary material	Allan et al., 2003, Cell 113(1): Supplementary material: tables S1 - S5. [FBrf0161463]

Allele Dmel\sqzie

Allele Dmel\sqz^ie