FlyBase Allele Report: Dmel\mod[UAS.cPa]

General Information

Symbol

Dmel\mod^UAS.cPa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Perrin

FlyBase ID

FBal0150340

Feature type

allele

Associated gene

Dmel\mod

Associated Insertion(s)

Carried in Construct

P{UAS-mod.P}

Key Links

Transgenic product class

cDNA

(Perrin et al., 2003)

wild_type

(Perrin et al., 2003)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Perrin et al., 2003)

wild_type

(Perrin et al., 2003)

Mutagen

in vitro construct

(Perrin et al., 2003)

Progenitor genotype

Carried in construct

P{UAS-mod.P}

Cytology

Description

UAS sequences drive expression of a mod cDNA.

(Perrin et al., 2003)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

mod

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased occurrence of cell division | somatic clone, with Scer\GAL4^Act5C.PP

(Perrin et al., 2003)

increased cell death, with Scer\GAL4^en-e16E

(Perrin et al., 2003)

increased cell death | larval stage, with Scer\GAL4^en-e16E

(Perrin et al., 2003)

increased cell size, with Scer\GAL4^en-e16E

(Perrin et al., 2003)

increased cell size | somatic clone, with Scer\GAL4^Act5C.PP

(Perrin et al., 2003)

Phenotype Manifest In

wing disc posterior compartment | larval stage, with Scer\GAL4^en-e16E

(Perrin et al., 2003)

Detailed Description

Statement

Reference

When mod^Scer\UAS.cPa is driven by Scer\GAL4^en-e16E no significant increase in the size of the posterior compartment of the wing disc is seen. There is a increase seen in the number of apoptotic cells in the posterior compartment. The cell cycle profiles of mutant cells is unaltered but both G1 and G2 cells are slightly bigger than normal. When clones expressing mod^Scer\UAS.cPa (driven by Scer\GAL4^Act5C.PP) are made no modification in growth rate or change in cell cycle profile is seen in clones, however a significantly slower proliferation is seen and correspondingly the cells are slightly larger than wild-type, although the effect is more pronounced in G2 than in G1 cells.

(Perrin et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^en-e16E, mod^UAS.cPa has increased cell death phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^en-e16E

(Perrin et al., 2003)

Scer\GAL4^en-e16E, mod^UAS.cPa has increased cell death | larval stage phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^en-e16E

(Perrin et al., 2003)

Enhancer of

Statement

Reference

mod^UAS.cPa/Scer\GAL4^Act5C.PP is an enhancer of increased occurrence of cell division | somatic clone phenotype of Scer\GAL4^Act5C.PP, stg^UAS.cNa

(Perrin et al., 2003)

Other

Statement

Reference

Scer\GAL4^Act5C.PP, mod^UAS.cPa, stg^UAS.cNa has increased occurrence of cell division | somatic clone phenotype

(Perrin et al., 2003)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

When stg^Scer\UAS.cNa and mod^Scer\UAS.cPa are both driven in clones, an enhancement is seen in the accelerated cell division phenotype seen in stg^Scer\UAS.cNa, Scer\GAL4^Act5C.PP animals.

(Perrin et al., 2003)

Xenogenetic Interactions

Statement

Reference

Although the addition of BacA\p35^Scer\UAS.cHa to mod^Scer\UAS.cPa, Scer\GAL4^en-e16E animals suppresses the increased cell death phenotype, the posterior/anterior ratio is unchanged.

(Perrin et al., 2003)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

mod^Scer\UAS.cPa

mod^UAS.cPa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Perrin

(Perrin et al., 2003)

Secondary FlyBase IDs

References (1)

Report Sections

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