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General Information
Symbol
Dmel\sxc6
Species
D. melanogaster
Name
FlyBase ID
FBal0150409
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G5320418A

Reported nucleotide change:

G?A

Comment:

AG to AA mutation in a splice acceptor.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide substitution of AG to AA destroys the splice acceptor site in the fourth intron of sxc.

sxc6 is a splice acceptor mutation of AG to AA.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

sxc6 is lethal in combination with sxcK872M.

sxc1/sxc6 transheterozygotes die at pharate adult stage.

Expressing sxcScer\UAS.cMa under the control of Scer\GAL4tub.PU partially rescues the lethality of sxc1/sxc6 transheterozygotes and although the majority of the surviving adults have normal wings, a significant proportion has wings with an ectopic vein; these surviving females have viable progeny.

Expressing either sxcH537A.Scer\UAS or sxcH596F.Scer\UAS under the control of Scer\GAL4tub.PU partially rescues the lethality of sxc1/sxc6 transheterozygotes but the majority of the surviving adults has wing defects which consist mostly of ectopic veins; the rest have normal wing morphology; these surviving females have viable progeny.

Expressing sxcD955A.Scer\UAS under the control of Scer\GAL4tub.PU partially rescue the lethality of sxc1/sxc6 transheterozygotes but the majority of surviving adults show wing defects, including ectopic veins, notches and blistering; the progeny of sxcD955A.Scer\UAS-rescued sxc1/sxc6 females dies before reaching second larval instar (crossed with either sxcD955A.Scer\UAS-rescued sxc1/sxc6 males) or adulthood (crossed with wild-type males) due to maternal effect.

Flies trans-heterozygous for sxc6 and sxc1, sxc3, nsxc4 or sxc5 develop into pharate adults showing a typical sxc mutant phenotype.

sxc2/sxc6 flies are viable and fertile, but exhibit wing abnormalities suggestive of wing-to-haltere transformations.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expressing sxcScer\UAS.cMa under the control of Scer\GAL4tub.PU partially rescues the lethality of sxc1/sxc6 transheterozygotes and although the majority of the surviving adults have normal wings, a significant proportion has wings with an ectopic vein; these surviving females have viable progeny.

Expressing either sxcH537A.Scer\UAS or sxcH596F.Scer\UAS under the control of Scer\GAL4tub.PU partially rescues the lethality of sxc1/sxc6 transheterozygotes but the majority of the surviving adults has wing defects which consist mostly of ectopic veins; the rest have normal wing morphology; these surviving females have viable progeny.

Expressing sxcD955A.Scer\UAS under the control of Scer\GAL4tub.PU partially rescue the lethality of sxc1/sxc6 transheterozygotes but the majority of surviving adults show wing defects, including ectopic veins, notches and blistering; the progeny of sxcD955A.Scer\UAS-rescued sxc1/sxc6 females dies before reaching second larval instar (crossed with either sxcD955A.Scer\UAS-rescued sxc1/sxc6 males) or adulthood (crossed with wild-type males) due to maternal effect.

Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
Comments
Comments

One of 6 alleles of this locus identified.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (10)