FB2025_01 , released February 20, 2025
Allele: Dmel\SCARUASp.cZa
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General Information
Symbol
Dmel\SCARUASp.cZa
Species
D. melanogaster
Name
FlyBase ID
FBal0150643
Feature type
allele
Associated gene
Dmel\SCAR
Associated Insertion(s)
Carried in Construct
P{UASp-SCAR.Z}
Also Known As
UAS-SCAR, UAS-WAVE
Key Links
Transgenic product class
cDNA
(Zallen et al., 2002)
wild_type
(Zallen et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Zallen et al., 2002)
wild_type
(Zallen et al., 2002)
Mutagen
in vitro construct
(Zallen et al., 2002)
Progenitor genotype
Carried in construct
P{UASp-SCAR.Z}
Cytology
Description

Expression of full length SCAR cDNA (SD02991) is under the control of UASp regulatory sequences.

(Zallen et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
SCAR
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of SCARScer\UAS.P\T.cZa under the control of Scer\GAL4OK107 does not result in axon growth defects in the mushroom body.

      (Ng and Luo, 2004)

      Overexpression of SCARScer\UAS.P\T.cZa under the control of Scer\GAL4elav-C155 does not result in any defects in the overall morphology of the embryonic nervous system.

      (Schenck et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      SCARUASp.cZa, Scer\GAL4elav-C155 is a non-suppressor of neuromuscular junction & synapse phenotype of Fmr1EP3517, Scer\GAL4elav-C155

      (Schenck et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Pan-neuronal expression of SCARScer\UAS.P\T.cZa under the control of Scer\GAL4elav-C155 weakly suppresses the AbiΔ20-dependent deficits in axonal targeting.

      (Stephan et al., 2011)

      Expression of SCARScer\UAS.P\T.cZa under the control of Scer\GAL4sca.PU suppresses the RP2 neuron migration defects seen in HemJ4-48 mutant embryos.

      (Zhu and Bhat, 2011)

      The reduced synaptic length seen at the neuromuscular junction in larvae expressing Fmr1EP3517 under the control of Scer\GAL4elav-C155 is not suppressed by co-expression of SCARScer\UAS.P\T.cZa.

      (Schenck et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4elav-C155/SCARUASp.cZa rescues SCARunspecified

      (Stephan et al., 2011)

      Scer\GAL4elav-C155/SCARUASp.cZa rescues SCARΔ37/SCAR[+]

      (Schenck et al., 2004)

      Scer\GAL4αTub84B.PL/SCARUASp.cZa rescues SCARΔ37

      (Zallen et al., 2002)

      Scer\GAL4αTub84B.PL/SCARUASp.cZa rescues SCARk13811

      (Zallen et al., 2002)
      Fails to rescue

      SCARUASp.cZa/Scer\GAL4GMR.PU fails to rescue SCARunspecified

      (Stephan et al., 2011)

      Scer\GAL4repo/SCARUASp.cZa fails to rescue SCARunspecified

      (Stephan et al., 2011)
      Comments

      Expression of SCARScer\UAS.P\T.cZa in neurons under the control of Scer\GAL4elav-C155 completely restores the axonal projections in SCARunspecified mutant brains.

      Expression of SCARScer\UAS.P\T.cZa in glia cell under the control of Scer\GAL4repo fails to restores the axonal projections in SCARunspecified mutant brains.

      Eye disc specific expression of SCARScer\UAS.P\T.cZa under the control of Scer\GAL4GMR.PU fails to rescue the axonal targeting defects in the visual system of SCARunspecified mutants.

      (Stephan et al., 2011)

      The reduced synaptic length seen at the neuromuscular junction of SCARΔ37/+ larvae is rescued by expression of SCARScer\UAS.P\T.cZa under the control of Scer\GAL4elav-C155.

      (Schenck et al., 2004)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SCARScer\UAS.P\T.cZa
      SCARUASp.cZa
      Name Synonyms
      Secondary FlyBase IDs
        References (7)