Allele Dmel\SCAR^{Scer\UAS.P\T.cZa}

General Information
Symbol	Dmel\SCAR^{Scer\UAS.P\T.cZa}	Species	D. melanogaster
Name		FlyBase ID	FBal0150643
Feature type	allele	Associated gene	Dmel\SCAR

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Zallen et al., 2002)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Expression of full length SCAR cDNA (SD02991) is under the control of Scer\UAS regulatory sequences and P\T promoter sequences. (Zallen et al., 2002)
Carried in construct	P{UASp-SCAR.Z} (Zallen et al., 2002, Ng and Luo, 2004, Schenck et al., 2004, Zhu and Bhat, 2011, Stephan et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class
	viable, with Scer\GAL4^elav-C155 (Schenck et al., 2004)
Phenotype Manifest In

Detailed Description
	Statement Reference Expression of SCAR^{Scer\UAS.P\T.cZa} under the control of Scer\GAL4^OK107 does not result in axon growth defects in the mushroom body. (Ng and Luo, 2004) Overexpression of SCAR^{Scer\UAS.P\T.cZa} under the control of Scer\GAL4^elav-C155 does not result in any defects in the overall morphology of the embryonic nervous system. (Schenck et al., 2004)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference SCAR^{Scer\UAS.P\T.cZa}, Scer\GAL4^ey-OK107 is an enhancer of neuroanatomy defective phenotype of LIMK1^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^ey-OK107 (Ng and Luo, 2004)
Suppressor of
Statement Reference Scer\GAL4^elav-C155/SCAR^{Scer\UAS.P\T.cZa} is a suppressor \| partially of neuroanatomy defective \| recessive \| third instar larval stage phenotype of Abi^Δ20 (Stephan et al., 2011) Scer\GAL4^sca.PU/SCAR^{Scer\UAS.P\T.cZa} is a suppressor of cell migration defective \| embryonic stage phenotype of Hem^J4-48 (Zhu and Bhat, 2011) Scer\GAL4^sca.PU/SCAR^{Scer\UAS.P\T.cZa} is a suppressor of neuroanatomy defective \| embryonic stage phenotype of Hem^J4-48 (Zhu and Bhat, 2011)
NOT Suppressor of
Statement Reference SCAR^{Scer\UAS.P\T.cZa}, Scer\GAL4^elav-C155 is a non-suppressor of neuroanatomy defective phenotype of Fmr1^EP3517, Scer\GAL4^elav-C155 (Schenck et al., 2004)
Phenotype Manifest In
Enhancer of
Statement Reference SCAR^{Scer\UAS.P\T.cZa}, Scer\GAL4^ey-OK107 is an enhancer of adult mushroom body phenotype of LIMK1^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^ey-OK107 (Ng and Luo, 2004)
Suppressor of
Statement Reference Scer\GAL4^elav-C155/SCAR^{Scer\UAS.P\T.cZa} is a suppressor \| partially of tract \| third instar larval stage phenotype of Abi^Δ20 (Stephan et al., 2011) Scer\GAL4^sca.PU/SCAR^{Scer\UAS.P\T.cZa} is a suppressor of RP2 motor neuron \| embryonic stage phenotype of Hem^J4-48 (Zhu and Bhat, 2011)
NOT Suppressor of
Statement Reference SCAR^{Scer\UAS.P\T.cZa}, Scer\GAL4^elav-C155 is a non-suppressor of neuromuscular junction & synapse phenotype of Fmr1^EP3517, Scer\GAL4^elav-C155 (Schenck et al., 2004)
Additional Comments
Genetic Interactions
Statement Reference Pan-neuronal expression of SCAR[Scer\UAS.P\T.cZa] under the control of Scer\GAL4[elav-C155] weakly suppresses the Abi[Δ20]-dependent deficits in axonal targeting. (Stephan et al., 2011) Expression of SCAR[Scer\UAS.P\T.cZa] under the control of Scer\GAL4[sca.PU] suppresses the RP2 neuron migration defects seen in Hem[J4-48] mutant embryos. (Zhu and Bhat, 2011) The reduced synaptic length seen at the neuromuscular junction in larvae expressing Fmr1^EP3517 under the control of Scer\GAL4^elav-C155 is not suppressed by co-expression of SCAR^{Scer\UAS.P\T.cZa}. (Schenck et al., 2004)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	Scer\GAL4^elav-C155/SCAR^{Scer\UAS.P\T.cZa} rescues SCAR^unspecified (Stephan et al., 2011) Scer\GAL4^elav-C155/SCAR^{Scer\UAS.P\T.cZa} rescues SCAR^Δ37/SCAR[+] (Schenck et al., 2004) Scer\GAL4^αTub84B.PL/SCAR^{Scer\UAS.P\T.cZa} rescues SCAR^K13811 (Zallen et al., 2002) Scer\GAL4^αTub84B.PL/SCAR^{Scer\UAS.P\T.cZa} rescues SCAR^Δ37 (Zallen et al., 2002)
Fails to rescue	SCAR^{Scer\UAS.P\T.cZa}/Scer\GAL4^GMR.PU fails to rescue SCAR^unspecified (Stephan et al., 2011) Scer\GAL4^repo/SCAR^{Scer\UAS.P\T.cZa} fails to rescue SCAR^unspecified (Stephan et al., 2011)
Comments	Expression of SCAR[Scer\UAS.P\T.cZa] in neurons under the control of Scer\GAL4[elav-C155] completely restores the axonal projections in SCAR[unspecified] mutant brains. Expression of SCAR[Scer\UAS.P\T.cZa] in glia cell under the control of Scer\GAL4[repo] fails to restores the axonal projections in SCAR[unspecified] mutant brains. Eye disc specific expression of SCAR[Scer\UAS.P\T.cZa] under the control of Scer\GAL4[GMR.PU] fails to rescue the axonal targeting defects in the visual system of SCAR[unspecified] mutants. (Stephan et al., 2011) The reduced synaptic length seen at the neuromuscular junction of SCAR^Δ37/+ larvae is rescued by expression of SCAR^{Scer\UAS.P\T.cZa} under the control of Scer\GAL4^elav-C155. (Schenck et al., 2004)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	SCAR^{Scer\UAS.P\T.cZa}
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Stephan et al., 2011, Mol. Biol. Cell 22(21): 4079--4092 Membrane-targeted WAVE mediates photoreceptor axon targeting in the absence of the WAVE complex in Drosophila. [FBrf0216499] Zhu and Bhat, 2011, Dev. Biol. 357(2): 283--294 The Hem protein mediates neuronal migration by inhibiting WAVE degradation and functions opposite of Abelson tyrosine kinase. [FBrf0214765] Ng and Luo, 2004, Neuron 44(5): 779--793 Rho GTPases Regulate Axon Growth through Convergent and Divergent Signaling Pathways. [FBrf0180582] Schenck et al., 2004, Dev. Biol. 274(2): 260--270 WAVE/SCAR, a multifunctional complex coordinating different aspects of neuronal connectivity. [FBrf0179776] Zallen et al., 2002, J. Cell Biol. 156(4): 689--701 SCAR is a primary regulator of Arp2/3-dependent morphological events in Drosophila. [FBrf0144948]

Allele Dmel\SCARScer\UAS.P\T.cZa

Allele Dmel\SCAR^{Scer\UAS.P\T.cZa}