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General Information
Symbol
Dmel\Nipped-ANC186
Species
D. melanogaster
Name
FlyBase ID
FBal0150723
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

T5198722A

Reported nucleotide change:

A?T

Reported nucleotide change:

T52327A

Amino acid change:

V1191D | Nipped-A-PE; V1191D | Nipped-A-PF

Reported amino acid change:

V885D

Reported amino acid change:

V1191D

Comment:

Position of mutation on reference sequence inferred by FlyBase curator. Based on sequence from Figure 7 of FBrf0174713.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Nucleotide numbering based on a hybrid sequence with the first nucleotide of the most 5' RACE product from an isogenic cn bw chromosome defined as nucleotide 1. Amino acid numbering based on residues encoded by the major Nipped-A transcript identified by authors.

Nucleotide substitution: T52327A.

Amino acid replacement: V1191D.

Amino acid replacement: V885D. Nucleotide substitution: A?T.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

At 18[o]C, 14.9% of pupae from a cross of Nipped-ANC186 x Df(2R)Nipped-E43 are of the Nipped-ANC186/Df(2R)Nipped-E43 genotype. At 25[o]C, only 2.3% have this genotype.

At 18[o]C, 3.7% of pupae from a cross of Nipped-ANC186 x Nipped-ANC106 are of the Nipped-ANC186/Nipped-ANC106 genotype.

At 18[o]C, 4.6% of pupae from a cross of Nipped-ANC186 x Nipped-ANC194 are of the Nipped-ANC186/Nipped-ANC194 genotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Phenotype Manifest In
Enhancer of
Statement
Reference

Nipped-A[+]/Nipped-ANC186 is an enhancer of wing blade phenotype of Nnd-1

NOT Enhancer of
Statement
Reference

Nipped-A[+]/Nipped-ANC186 is a non-enhancer of wing margin phenotype of mamg2.1

NOT Suppressor of
Statement
Reference

Nipped-A[+]/Nipped-ANC186 is a non-suppressor of wing vein L4 phenotype of NAx-E2

Additional Comments
Genetic Interactions
Statement
Reference

Heterozygosity for Nipped-ANC186 further reduces the width of Nnd-1 wings.

Xenogenetic Interactions
Statement
Reference

Nipped-ANC186/+ enhances the eye degeneration phenotype caused by expression of Hsap\HTTQ93.ex1p.Scer\UAS under the control of Scer\GAL4GMR.PU.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (4)