FB2025_01 , released February 20, 2025
Allele: Dmel\Nipped-ANC116
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General Information
Symbol
Dmel\Nipped-ANC116
Species
D. melanogaster
Name
FlyBase ID
FBal0150724
Feature type
allele
Associated gene
Dmel\Nipped-A
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Myster and Peifer, 2003.9.11)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G?A. G to A transition in the first base of the intron following exon 4, disrupting the conserved GT dinucleotide in the 5' splice site consensus sequence. Predicted to disrupt splicing.

(Myster et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:5,204,004..5,204,004 [-]
Nucleotide change:

G5204004A

Comment:

Position of mutation on reference sequence inferred by FlyBase curator. Mutation is in splice donor site. Predicted to disrupt splicing after exon 10 (FlyBase curator inference based on sequence in Figure 7 of FBrf0174713).

(Myster et al., 2004)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Nipped-ANC116/Nipped-A[+] is an enhancer of visible | progressive phenotype of Hsap\HTTQ93.ex1.UAS, Scer\GAL4GMR.PU

      (Zhang et al., 2010)
      Suppressor of
      Statement
      Reference

      Nipped-ANC116 is a suppressor of short lived | RU486 conditional phenotype of Hsap\ATXN7102Q.T.UAS.Tag:NLS(SV40-largeT), Scer\GAL4elav.Switch.PO

      (Latouche et al., 2007)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Nipped-ANC116/Nipped-A[+] is an enhancer of eye | progressive phenotype of Hsap\HTTQ93.ex1.UAS, Scer\GAL4GMR.PU

      (Zhang et al., 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Nipped-ANC116/+ enhances the eye degeneration phenotype caused by expression of Hsap\HTTQ93.ex1p.Scer\UAS under the control of Scer\GAL4GMR.PU.

      (Zhang et al., 2010)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Induced on: cn1 bw1.

      (Myster and Peifer, 2003.9.11)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Nipped-ANC116
      (Zhang et al., 2010, Gambetta and Müller, 2009.8.18, Latouche et al., 2007, Gause et al., 2006)
      l(2)NC116
      (Myster et al., 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)