Allele Dmel\Mmp1^f1.Scer\UAS

General Information
Symbol	Dmel\Mmp1^f1.Scer\UAS	Species	D. melanogaster
Name		FlyBase ID	FBal0150755
Feature type	allele	Associated gene	Dmel\Mmp1

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Page-McCaw et al., 2003)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Expression of Mmp1 isoform f1 cDNA, is under the control of Scer\UAS sequences. (Page-McCaw et al., 2003)
Carried in construct	P{UAS-Mmp1.f1} (Medioni and Noselli, 2005, Page-McCaw et al., 2003, Miller et al., 2011, Glasheen et al., 2009, Schmidt et al., 2011)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage, with Scer\GAL4^Cg.PA (Schmidt et al., 2011)
Phenotype Manifest In
	adult thoracic sensillum, with Scer\GAL4^dpp.PH (Glasheen et al., 2009) chaeta, with Scer\GAL4^dpp.PH (Glasheen et al., 2009) macrochaeta & adult thorax, with Scer\GAL4^dpp.PH (Page-McCaw et al., 2003)
Detailed Description
	Statement Reference Expression of Mmp1[f1.Scer\UAS] under the control of Scer\GAL4[dpp.PH] results in short stubby, easily broken bristles on the thorax of adult flies. (Glasheen et al., 2009) Expression of Mmp1^f1.Scer\UAS in border cells, driven by Scer\GAL4^slbo.2.6 does not affect the formation of the egg chamber apical cap or the migration of the border cell cluster to the oocyte. (Medioni and Noselli, 2005) Mmp1^f1.Scer\UAS; Scer\GAL4^GMR.PF flies have normal eyes. The thoracic macrochaetae of Mmp1^f1.Scer\UAS; Scer\GAL4^dpp.PH flies tend to break of shortly after eclosion. (Page-McCaw et al., 2003)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement Reference Mmp1^f1.Scer\UAS, Scer\GAL4^dpp.PH has macrochaeta & thorax phenotype, suppressible by Timp^Scer\UAS.cPa, Scer\GAL4^dpp.PH (Page-McCaw et al., 2003)
Additional Comments
Genetic Interactions
Statement Reference The thoracic macrochaeta phenotype due to Mmp1^f1.Scer\UAS; Scer\GAL4^dpp.PH is suppressed by the presence of one copy of Timp^Scer\UAS.cPa. (Page-McCaw et al., 2003)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	Mmp1^f1.Scer\UAS is rescued by Mmp1^{Pro-pex.f1.Scer\UAS}/Scer\GAL4^dpp.PH (Glasheen et al., 2009)
Comments	Expression of Mmp1[Pro-pex.f1.Scer\UAS] suppresses the bristle phenotype observed in flies expressing Mmp1[f1.Scer\UAS] under the control of Scer\GAL4[dpp.PH]. (Glasheen et al., 2009)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Mmp1^f1.Scer\UAS
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Miller et al., 2011, J. Neurosci. 31(14): 5335--5347 Drosophila mmp2 regulates the matrix molecule faulty attraction (frac) to promote motor axon targeting in Drosophila. [FBrf0213409] Schmidt et al., 2011, Self Nonself 2(3): 125--141 Cleavage of PGRP-LC receptor in the Drosophila IMD pathway in response to live bacterial infection in S2 cells. [FBrf0218028] Glasheen et al., 2009, Proc. Natl. Acad. Sci. U.S.A. 106(8): 2659--2664 Distinct functions for the catalytic and hemopexin domains of a Drosophila matrix metalloproteinase. [FBrf0206699] Medioni and Noselli, 2005, Development 132(13): 3069--3077 Dynamics of the basement membrane in invasive epithelial clusters in Drosophila. [FBrf0187473] Page-McCaw et al., 2003, Dev. Cell 4(1): 95--106 Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development. [FBrf0155689]

Allele Dmel\Mmp1f1.Scer\UAS

Allele Dmel\Mmp1^f1.Scer\UAS