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General Information
Symbol
Dmel\Mmp1W208stop
Species
D. melanogaster
Name
FlyBase ID
FBal0150757
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G24676009A

Amino acid change:

W208term | Mmp1-PC; W208term | Mmp1-PD; W208term | Mmp1-PE; W208term | Mmp1-PF; W208term | Mmp1-PG; W208term | Mmp1-PH; W208term | Mmp1-PI; W208term | Mmp1-PJ; W208term | Mmp1-PK; W208term | Mmp1-PL

Reported amino acid change:

W208term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation. (exact site of mutation unspecified). Site of nucleic acid difference in mutant inferred by FlyBase based on reported amino acid change. The current annotation uses an upstream AUG 29aa upstream relative to previous reports. This accounts for the discrepency in the reported vs. annotated amino acid coordinate of the mutation.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: W208term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Some Mmp1W208stop mutants die during the second larval instar (about 40%), most of the rest die during the third larval instar, which lasts several days longer than in wild-type. Only 4% pupariate, and none of these undergo head eversion, or eclose. Most Mmp1W208stop/Mmp12 animals survive to third instar (90%), but only 6% pupariate; 4% undergo head eversion, but none eclose.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Mmp1W208stop
Name Synonyms
Secondary FlyBase IDs
    References (1)