FB2025_01 , released February 20, 2025
Allele: Dmel\I-2UAS.Tag:polyHis,Tag:MYC
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General Information
Symbol
Dmel\I-2UAS.Tag:polyHis,Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0150771
Feature type
allele
Associated gene
Dmel\I-2
Associated Insertion(s)
Carried in Construct
P{UAS-I-2.HA}
Key Links
Transgenic product class
wild_type
(Bennett et al., 2003)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Bennett et al., 2003)
Mutagen
in vitro construct
(Bennett et al., 2003)
Progenitor genotype
Carried in construct
P{UAS-I-2.HA}
Cytology
Description

UAS regulatory sequences drive expression of I-2.

(Bennett et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
I-2
Tagged with
Tag:MYC
Tag:polyHis
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of I-2Scer\UAS.T:Zzzz\His6,T:Hsap\MYC in the eye disc, driven by Scer\GAL4GMR.PF, does not affect eye disc morphology and causes mild or no axon mistargeting in the optic lobes.

      (Babu et al., 2005)

      Flies expressing I-2Scer\UAS.T:Zzzz\His6,T:Hsap\MYC under the control of Scer\GAL4vg.PM resemble wild type.

      (Bennett et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Suppressed by
      NOT suppressed by
      Enhancer of
      Phenotype Manifest In
      NOT Enhanced by
      Suppressed by
      NOT suppressed by
      Enhancer of
      Statement
      Reference

      I-2UAS.Tag:polyHis,Tag:MYC, Scer\GAL4arm.PS is an enhancer of mitosis & nuclear chromosome phenotype of NiPp1UAS.Tag:HA, Scer\GAL4arm.PS

      (Bennett et al., 2003)

      I-2UAS.Tag:polyHis,Tag:MYC, Scer\GAL4vg.PM is an enhancer of wing phenotype of Scer\GAL4vg.PM, putUAS.cMa

      (Bennett et al., 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of I-2Scer\UAS.T:Zzzz\His6,T:Hsap\MYC enhances the mitotic defects seen in larvae expressing NiPp1Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4arm.PS. The modest wing overgrowth phenotype caused by expression of putScer\UAS.cMa under the control of Scer\GAL4vg.PM is enhanced by co-expression of I-2Scer\UAS.T:Zzzz\His6,T:Hsap\MYC.

      (Bennett et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      I-2Scer\UAS.T:Zzzz\His6,T:Hsap\MYC
      I-2UAS.Tag:polyHis,Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (7)