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General Information
Symbol
Dmel\Act5Cslbo.EGFP
Species
D. melanogaster
Name
FlyBase ID
FBal0150991
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Expression of Act5C fused at the N-terminus to EGFP is under the control of 2 copies of a 2.6kb slbo enhancer fragment fused to Hsp70 minimal promoter sequences.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

border follicle cell & filopodium

Detailed Description
Statement
Reference

In Act5Cslbo.T:Avic\GFP-EGFP (2 copies of 'strong' insertion P{slbo-EGFP::Act5C}2) animals the initiation of border follicle cell migration is inhibited. Arrested or delayed border cell clusters initially form normal looking cellular extensions, but these continue to grow as the border cell bodies fail to move. The extensions become very long and cease to be straight (as wild-type are), but continue to extend in the correct direction. These extra long cellular extensions sometimes fragment. Occasionally, a second border cell forms a second long cellular extension that follows a separate path.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of Act5Cslbo.T:Avic\GFP-EGFP and of psidinScer\UAS.cKa under the control of Scer\GAL4slbo.2.6 results in a strong inhibition of border follicle cell migration.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Act5Cslbo.EGFP
Act5Cslbo.T:Avic\GFP-EGFP
Name Synonyms
Secondary FlyBase IDs
    References (2)