Allele Dmel\tau^{Scer\UAS.P\T.T:Avic\GFP-m6}

General Information
Symbol	Dmel\tau^{Scer\UAS.P\T.T:Avic\GFP-m6}	Species	D. melanogaster
Name		FlyBase ID	FBal0151384
Feature type	allele	Associated gene	Dmel\tau

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - coding region fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Doerflinger et al., 2003) in vitro construct - regulatory fusion (Doerflinger et al., 2003)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Scer\UAS regulatory and P\T promoter sequences drive expression of the full length tau-A open reading frame, tagged at the C-terminal end with T:Avic\GFP^m6. (Doerflinger et al., 2003)
Carried in construct	P{UASp-tau.A:mGFP6} (Doerflinger et al., 2003, Bettencourt da Cruz et al., 2005, Tian and Deng, 2009, Sung et al., 2008)
Tagged with	T:Avic\GFP^m6 (Doerflinger et al., 2003)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference Expression of tau[Scer\UAS.P\T.T:Avic\GFP-m6] under the control of Scer\GAL4[mat.αTub67C.T:Hsim\VP16] has no effect on oocyte nucleus localisation. (Tian and Deng, 2009)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement Reference Scer\GAL4^elav-C155/tau^{Scer\UAS.P\T.T:Avic\GFP-m6} is a suppressor \| partially of neuropil phenotype of futsch^olk1 (Bettencourt da Cruz et al., 2005) tau^{Scer\UAS.P\T.T:Avic\GFP-m6}/Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} is a suppressor \| partially of oocyte nucleus phenotype of Scer\GAL4^{mat.αTub67C.T:Hsim\VP16}, par-1^{Scer\UAS.ΔSP.T:Avic\GFP} (Tian and Deng, 2009)
Additional Comments
Genetic Interactions
Statement Reference The penetrance of the oocyte mislocalisation phenotype seen in egg chambers of females expressing par-1[Scer\UAS.ΔSP.T:Avic\GFP] under the control of Scer\GAL4[mat.αTub67C.T:Hsim\VP16] is reduced by co-expression of tau[Scer\UAS.P\T.T:Avic\GFP-m6] (from 96% to 33%). (Tian and Deng, 2009) Flies that express tau^{Scer\UAS.P\T.T:Avic\GFP-m6} under the control of Scer\GAL4^elav-C155 show a 25% reduction in the size of vacuoles that develop in the mechanosensory neuropil compared to futsch^olk1 flies that do not express the transgene. (Bettencourt da Cruz et al., 2005)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	tau^{Scer\UAS.P\T.T:Avic\GFP-m6}/Scer\GAL4^{mat.αTub67C.T:Hsim\VP16} rescues tau^MR22 (Tian and Deng, 2009)
Comments	The oocyte nucleus mislocalisation defect seen in tau[MR22] germline clones is rescued by expression of tau[Scer\UAS.P\T.T:Avic\GFP-m6] under the control of Scer\GAL4[mat.αTub67C.T:Hsim\VP16]. (Tian and Deng, 2009)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	tau^{Scer\UAS.P\T.T:Avic\GFP-m6}
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Tian and Deng, 2009, Dev. Biol. 327(2): 458--464 Par-1 and Tau regulate the anterior-posterior gradient of microtubules in Drosophila oocytes. [FBrf0207584] Sung et al., 2008, Dev. Cell 15(6): 866--876 Drosophila ensconsin promotes productive recruitment of Kinesin-1 to microtubules. [FBrf0206603] Bettencourt da Cruz et al., 2005, Mol. Biol. Cell 16(5): 2433--2442 Disruption of the MAP1B-related protein FUTSCH leads to changes in the neuronal cytoskeleton, axonal transport defects, and progressive neurodegeneration in Drosophila. [FBrf0188078] Doerflinger et al., 2003, Development 130(17): 3965--3975 The role of PAR-1 in regulating the polarised microtubule cytoskeleton in the Drosophila follicular epithelium. [FBrf0160491]

Allele Dmel\tauScer\UAS.P\T.T:Avic\GFP-m6

Allele Dmel\tau^{Scer\UAS.P\T.T:Avic\GFP-m6}