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General Information
Symbol
Dmel\tauUASp.mGFP6
Species
D. melanogaster
Name
FlyBase ID
FBal0151384
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-dTau, UAS-tau-GFP
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASp regulatory sequences drive expression of the full length tau-A open reading frame, tagged at the C-terminal end with mGFP6.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of tauScer\UAS.P\T.T:Avic\GFP-m6 under the control of Scer\GAL4BG380 in larval neuromuscular junctions does not lead to specific accumulation of a subset of synaptic cargo in axons, as compared to controls.

Expression of tauScer\UAS.P\T.T:Avic\GFP-m6 under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 has no effect on oocyte nucleus localisation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The penetrance of the oocyte mislocalisation phenotype seen in egg chambers of females expressing par-1Scer\UAS.ΔSP.T:Avic\GFP under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 is reduced by co-expression of tauScer\UAS.P\T.T:Avic\GFP-m6 (from 96% to 33%).

Flies that express tauScer\UAS.P\T.T:Avic\GFP-m6 under the control of Scer\GAL4elav-C155 show a 25% reduction in the size of vacuoles that develop in the mechanosensory neuropil compared to futscholk1 flies that do not express the transgene.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of tauScer\UAS.P\T.T:Avic\GFP-m6 significantly rescues the retinal degeneration seen in one week old flies expressing tauGD8682 under the control of Scer\GAL4GMR.PU.

Expression of tauScer\UAS.P\T.T:Avic\GFP-m6 partially rescues the semi-lethality seen when tauGD8682 is expressed under the control of Scer\GAL4Appl.G1a.

The oocyte nucleus mislocalisation defect seen in tauMR22 germline clones is rescued by expression of tauScer\UAS.P\T.T:Avic\GFP-m6 under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
tauScer\UAS.P\T.T:Avic\GFP-m6
tauUASp.mGFP6
Name Synonyms
Secondary FlyBase IDs
    References (8)