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General Information
Symbol
Dmel\tauMR22
Species
D. melanogaster
Name
FlyBase ID
FBal0151385
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

62kb deletion extending proximally from P{EP}tauEP3203, removing almost all the tau locus, including the exons that encode the microtubule binding domain.

Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
 

Phenotypes in the Hsap\APP1-40.Scer\UAS.T:SS-nec Alzheimer's Disease model are suppressed when tauMR22 is transheterozygous with tauEP3203.

Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

tauMR22/+ larvae do not exhibit specific accumulation of a subset of synaptic cargo in axons, as compared to controls.

tauMR22/tauEP3203 mutant flies exhibit mild climbing defects compared to controls.

The oocyte nucleus is mislocalised to the central or lateral region of the oocyte in 58% of stage 10 egg chambers of females containing homozygous tauMR22 germline clones.

Germline and follicle cell clones of Df(3R)MR22 have no microtubule defects.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
NOT Suppressor of
Statement
Reference

tauMR22/tau[+] is a non-suppressor of axon | larval stage phenotype of Scer\GAL4BG380, par-1UAS.cSa

Additional Comments
Genetic Interactions
Statement
Reference

tauMR22/+ fails to suppress the axonal transport defects seen in flies expressing par-1Scer\UAS.cSa under the control of Scer\GAL4BG380.

The pruning defects observed in class IV dendritic arborizing neurons of pupae expressing par-1HMS00405 under the control of Scer\GAL4ppk.PG or in par-1Δ-16 mutant MARCM clones are significantly suppressed by combination with a single copy of tauMR22.

Xenogenetic Interactions
Statement
Reference

tauMR22/tauEP3203 suppresses the climbing defects seen in flies expressing Hsap\APPArctic.Scer\UAS.T:SS-nec under the control of Scer\GAL4elav.Switch.PO from 2 day post-eclosion onwards (expression induced by feeding flies RU486). This rescue is further enhanced by feeding the flies lithium in adulthood.

Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (8)