Open Close
General Information
Symbol
Dmel\tauEP3203
Species
D. melanogaster
Name
FlyBase ID
FBal0151387
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

P{EP} insertion in the first intron.

Insertion components
P{EP}tauEP3203
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
 

Phenotypes in the Hsap\APP1-40.Scer\UAS.T:SS-nec Alzheimer's Disease model are suppressed when tauEP3203 is transheterozygous with tauMR22.

Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

tauMR22/tauEP3203 mutant flies exhibit mild climbing defects compared to controls.

Homozygotes have no obvious morphological or behavioural defects. The organisation of microtubules in the follicle and germline cells is indistinguishable from wild type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

tauEP3203/tauEP3203 or tauEP3203/+ significantly partially suppresses bang-sensitive behavior in kccDHS1/kccDHS1 flies, and Df(3R)MR22/tauEP3203 significantly partially suppresses bang-sensitive behavior in eas2/eas2 flies.

Xenogenetic Interactions
Statement
Reference

tauMR22/tauEP3203 suppresses the climbing defects seen in flies expressing Hsap\APPArctic.Scer\UAS.T:SS-nec under the control of Scer\GAL4elav.Switch.PO from 2 day post-eclosion onwards (expression induced by feeding flies RU486). This rescue is further enhanced by feeding the flies lithium in adulthood.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (7)