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General Information
Symbol
Dmel\spenDN.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0151449
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of the C-terminal 936 amino acids of spen.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of spenDN.Scer\UAS under the control of Scer\GAL4sev.PR results in a rough eye phenotype.

Expression of spenDN.Scer\UAS under the control of Scer\GAL4ptc-559.1 in the leg disc results in a complete breakdown of disc morphology at 25oC. At 18-22oC, small leg discs are seen. Expression of spenDN.Scer\UAS under the control of Scer\GAL4da.G32 at 25oC results in embryos with cuticle phenotypes ranging from wild type to moderate reduction of denticle formation. At 29oC, complete disruption of cuticle formation is seen. Expression of spenDN.Scer\UAS under the control of Scer\GAL4da.G32 does not result in ventral cuticle defects, even at 29oC.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Suppressed by
Statement
Reference
Suppressor of
NOT Suppressor of
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of nitoScer\UAS.T:Hsap\MYC enhances the rough eye phenotype caused by expression of spenDN.Scer\UAS under the control of Scer\GAL4sev.PR, resulting in complete loss of organisation in the eye and an increase in necroses in the eye.

Co-expression of nitodsRNA.Scer\UAS partially suppresses the rough eye phenotype caused by expression of spenDN.Scer\UAS under the control of Scer\GAL4sev.PR, with the eyes having fewer missing ommatidia, fewer missing photoreceptor cells in ommatidia lacking the full complement of photoreceptor cells and more normal rhabdomere morphology.

Co-expression of spenDN.Scer\UAS suppresses the reduced eye phenotype caused by expression of armS56F.GMR under the control of Scer\GAL4GMR.PF. Co-expression of spenDN.Scer\UAS suppresses the small eye phenotype caused by expression of EgfrDN.Scer\UAS under the control of Scer\GAL4GMR.PF.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
spenDN.Scer\UAS
spenDN.UAS
Name Synonyms
Secondary FlyBase IDs
    References (2)