FB2025_01 , released February 20, 2025
Allele: Dmel\savSH13
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General Information
Symbol
Dmel\savSH13
Species
D. melanogaster
Name
FlyBase ID
FBal0151558
Feature type
allele
Associated gene
Dmel\sav
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Jia et al., 2003)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      savSH13 mutant intestinal stem cell clones exhibit overgrowth.

      (Huang et al., 2014)

      Homozygous clones in the eye disc result in overgrowth and adults have enlarged and folded eyes.

      (Guo et al., 2013)

      savSH13 mutant eye clones exhibit overgrowth.

      (Huang et al., 2013)

      Adult eyes carrying homozygous mutant clones are overgrown.

      (Zhang et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      NOT suppressed by
      Statement
      Reference

      savSH13 has eye | somatic clone phenotype, non-suppressible by par-1HMS00405/Scer\GAL4unspecified

      (Huang et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of mir-bansponge.UAS.DsRed(Unk) suppresses the increase in intestinal stem cell division in savSH13 mutant clones.

      (Huang et al., 2014)

      Expression of TgiScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4tub.PU in savSH13 clones in the eye disc results in adults with nearly normal eyes.

      (Guo et al., 2013)

      Expression of par-1HMS00405 under the control of Scer\GAL4unspecified does not suppress the eye overgrowth seen in savSH13 mutant eye clones.

      (Huang et al., 2013)

      The eye overgrowth phenotype caused by savSH13 clones is almost completely suppressed by co-expression of sddsRNA.N.Scer\UAS and sddsRNA.C.Scer\UAS under the control of Scer\GAL4tub.

      (Zhang et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      savSH13
      (Dong et al., 2015, Guo et al., 2013, Huang et al., 2013, Zhang et al., 2008)
      savsh13
      (Huang et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)