FB2025_01 , released February 20, 2025
Allele: Dmel\mtrmKG08051
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General Information
Symbol
Dmel\mtrmKG08051
Species
D. melanogaster
Name
FlyBase ID
FBal0151718
Feature type
allele
Associated gene
Dmel\mtrm
Associated Insertion(s)
P{SUPor-P}Exo70KG08051
Carried in Construct
Also Known As
mtrmKG, KG08051
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Koon et al., 2018)
Mutagen
P-element activity
(Harris et al., 2003)
Progenitor genotype
Associated Insertion(s)
P{SUPor-P}Exo70KG08051
Cytology
Description

Insertion 80bp upstream of the first ATG in the mtrm coding sequence.

(Xiang et al., 2007)

P{SUPor-P} insertion in the third intron of exo70. The insertion is also 90bp upstream of the predicted start codon of mtrm (mtrm is nested within the third intron of exo70).

(Harris et al., 2003)
Allele components
Component
Use(s)
Inserted element
P{SUPor-P}
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygosity for mtrmKG08051 results in elevated X (49.8%) and fourth (33.8%) chromosome nondisjunction in In(1)FM7/X ; svspa-pol females compared to controls. The level of X chromosome nondisjunction in heterozygous mtrmKG08051 females carrying two normal sequence X chromosomes is only 4.4%, while the frequency of fourth chromosome nondisjunction in these females is 26.0%.

      (Harris et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      mtrmKG08051 is rescued by Scer\GAL4VP16.nanos.UTR/mtrmUASp.cHa

      (Harris et al., 2003)
      Comments

      The elevated X and fourth chromosome nondisjunction seen in In(1)FM7/X ; svspa-pol females heterozygous for mtrmKG08051 is largely rescued by expression of mtrmScer\UAS.P\T.cHa under the control of Scer\GAL4nos.UTR.T:Hsim\VP16; the rescued females show only 2.7% X and 7.1% fourth chromosome nondisjunction.

      (Harris et al., 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Precise excision of the P{SUPor-P} element reverts the high levels of nondisjunction and the recessive female sterility caused by the P{SUPor-P}exo70KG08051 insertion.

      (Harris et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      mtrmKG08051
      (Haseeb et al., 2024, Haseeb et al., 2024, Hanlon et al., 2018, Bauerly et al., 2014)
      mtrmKG
      (Haseeb et al., 2024, Haseeb et al., 2024, Perkins et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)