Allele Dmel\edl^Scer\UAS.cYa

General Information
Symbol	Dmel\edl^Scer\UAS.cYa	Species	D. melanogaster
Name	Saccharomyces cerevisiae UAS construct a of Yamada	FlyBase ID	FBal0151997
Feature type	allele	Associated gene	Dmel\edl

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Yamada et al., 2003)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Scer\UAS regulatory sequences drive expression of the edl open reading frame. (Yamada et al., 2003)
Carried in construct	P{UAS-edl.Y} (Yamada et al., 2003)
Cytology
Phenotypic Data
Phenotypic Class
	visible, with Scer\GAL4^elav-C155 (Yamada et al., 2003) visible, with Scer\GAL4^en-e16E (Yamada et al., 2003) visible, with Scer\GAL4^hs.2sev (Yamada et al., 2003)
Phenotype Manifest In
	dorsal appendage, with Scer\GAL4^CY2 (Yamada et al., 2003) eye, with Scer\GAL4^elav-C155 (Yamada et al., 2003) eye photoreceptor cell, with Scer\GAL4^elav-C155 (Yamada et al., 2003) ommatidial precursor cluster, with Scer\GAL4^elav-C155 (Yamada et al., 2003) ommatidium, with Scer\GAL4^hs.2sev (Yamada et al., 2003) photoreceptor cell R7, with Scer\GAL4^hs.2sev (Yamada et al., 2003) wing, with Scer\GAL4^en-e16E (Yamada et al., 2003)
Detailed Description
	Statement Reference Expression of edl^Scer\UAS.cYa under the control of Scer\GAL4^elav-C155 results in a reduction in eye size. Photoreceptors neurons are hardly detected and most of the retina is occupied by pigment cells. In the developing eye disc, a massive reduction of differentiating neurons is seen from the earliest stages of ommatidial assembly, although R8 specification is largely unaffected. Expression of edl^Scer\UAS.cYa under the control of Scer\GAL4^hs.2sev does not transform cone cells towards a neuronal fate and suppresses the formation of the endogenous R7 neurons. Expression of edl^Scer\UAS.cYa under the control of Scer\GAL4^hs.2sev results in a rough eye phenotype. Expression of edl^Scer\UAS.cYa under the control of Scer\GAL4^CY2 dorsalises the chorion, resulting in fused dorsal appendages. Expression of edl^Scer\UAS.cYa under the control of Scer\GAL4^en-e16E results in a duplication of the wing. (Yamada et al., 2003)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Scer\GAL4^hs.2sev, edl^Scer\UAS.cYa has visible phenotype, enhanceable by pnt[+]/pnt^Δ88 (Yamada et al., 2003)
Phenotype Manifest In
Enhanced by
Statement Reference Scer\GAL4^hs.2sev, edl^Scer\UAS.cYa has ommatidium phenotype, enhanceable by pnt[+]/pnt^Δ88 (Yamada et al., 2003)
Suppressor of
Statement Reference edl^Scer\UAS.cYa, Scer\GAL4^hs.2sev is a suppressor of photoreceptor cell R7 \| ectopic phenotype of Ras85D^V12.sev, Scer\GAL4^hs.2sev (Yamada et al., 2003)
Additional Comments
Genetic Interactions
Statement Reference Expression of edl^Scer\UAS.cYa under the control of Scer\GAL4^hs.2sev suppresses the ectopic R7 neurons caused by expression of Ras85D^V12.sev. The rough eye phenotype caused by expression of edl^Scer\UAS.cYa under the control of Scer\GAL4^hs.2sev is enhanced by pnt^Δ88/+. (Yamada et al., 2003)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	edl^Scer\UAS.cYa
Name Synonym	Saccharomyces cerevisiae UAS construct a of Yamada (Yamada et al., 2003)
Secondary FlyBase IDs

References ( 1 )
Research paper	Yamada et al., 2003, Development 130(17): 4085--4096 EDL/MAE regulates EGF-mediated induction by antagonizing Ets transcription factor Pointed. [FBrf0161068]

Allele Dmel\edlScer\UAS.cYa

Allele Dmel\edl^Scer\UAS.cYa