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General Information
Symbol
Dmel\ed4.12
Species
D. melanogaster
Name
FlyBase ID
FBal0152008
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: single amino acid change.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygotes and ed4.12/edlH23 flies have a rough eye phenotype. Twinning of R8 photoreceptor cells is seen in ed4.12/ed4.12, ed4.12/ed4.4, ed4.12/ed6.1 and ed4.12/Df(2L)ed-dp animals. Variation in the number and arrangement of R7 and other photoreceptors is seen in ed4.12 eyes. The presence of extra R7 cells is correlated very strongly with the presence of extra R8 cells.

ed4.12 homozygous flies have extra dorsocentral, scutellar and recurved wing margin bristles (chemosensory ventral triple row + dorsal triple row). They also have extra thoracic microchaetae.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

ed[+]/ed4.12 is an enhancer of visible phenotype of Scer\GAL4sca-109-68, atoUAS.cJa

Phenotype Manifest In
Enhanced by
Statement
Reference

ed4.12 has photoreceptor cell R8 | increased number phenotype, enhanceable by aosΔ7/argos[+]

NOT Enhanced by
Statement
Reference

ed4.12 has photoreceptor cell R8 | increased number phenotype, non-enhanceable by N[+]/N55e11

ed4.12 has chemosensory ventral triple row & microchaeta | ectopic phenotype, non-enhanceable by aosΔ7

ed4.12 has dorsal triple row & microchaeta | ectopic phenotype, non-enhanceable by aosΔ7

ed4.12 has dorsocentral bristle | ectopic phenotype, non-enhanceable by aosΔ7

ed4.12 has scutellar bristle | ectopic phenotype, non-enhanceable by aosΔ7

ed4.12 has chemosensory ventral triple row & microchaeta | ectopic phenotype, non-enhanceable by Egfr[+]/Egfrf2

ed4.12 has dorsal triple row & microchaeta | ectopic phenotype, non-enhanceable by Egfr[+]/Egfrf2

ed4.12 has dorsocentral bristle | ectopic phenotype, non-enhanceable by Egfr[+]/Egfrf2

ed4.12 has scutellar bristle | ectopic phenotype, non-enhanceable by Egfr[+]/Egfrf2

Suppressed by
Statement
Reference

ed4.12 has photoreceptor cell R8 | increased number phenotype, suppressible by Egfr[+]/Egfrf2

ed4.12 has chemosensory ventral triple row & microchaeta | ectopic phenotype, suppressible by H1

ed4.12 has dorsal triple row & microchaeta | ectopic phenotype, suppressible by H1

ed4.12 has dorsocentral bristle | ectopic phenotype, suppressible by H1

ed4.12 has scutellar bristle | ectopic phenotype, suppressible by H1

NOT suppressed by
Statement
Reference

ed4.12 has photoreceptor cell R8 | increased number phenotype, non-suppressible by N[+]/N55e11

ed4.12 has dorsal triple row & microchaeta | ectopic phenotype, non-suppressible by aosΔ7

ed4.12 has dorsocentral bristle | ectopic phenotype, non-suppressible by aosΔ7

ed4.12 has scutellar bristle | ectopic phenotype, non-suppressible by aosΔ7

ed4.12 has chemosensory ventral triple row & microchaeta | ectopic phenotype, non-suppressible by Egfr[+]/Egfrf2

ed4.12 has dorsal triple row & microchaeta | ectopic phenotype, non-suppressible by Egfr[+]/Egfrf2

ed4.12 has dorsocentral bristle | ectopic phenotype, non-suppressible by Egfr[+]/Egfrf2

ed4.12 has scutellar bristle | ectopic phenotype, non-suppressible by Egfr[+]/Egfrf2

ed4.12 has chemosensory ventral triple row & microchaeta | ectopic phenotype, non-suppressible by aosΔ7

Enhancer of
Suppressor of
Statement
Reference

ed4.12 is a suppressor of phenotype of ato2

Other
Additional Comments
Genetic Interactions
Statement
Reference

The rough eye phenotype and R8 cell twinning phenotype caused by expression of atoScer\UAS.cJa under the control of Scer\GAL4sca-109-68 is dominantly enhanced by ed4.12. The ed4.12 R8 cell twinning phenotype is not altered by N55e11/+. The ed4.12 R8 cell twinning phenotype is strongly suppressed by Egfrf2/+ or Ras85Dunspecified/+. The ed4.12 R8 cell twinning phenotype is strongly enhanced by argosΔ7/+. Egfrf2 clones in the eye disc induced in a homozygous ed4.12 background show abnormal spacing of R8 cells in the clone, but R8 cells rarely appear twinned. The ed4.12 R8 cell twinning phenotype is not affected in spiSC2 homozygous clones in a ed4.12 background.

ed4.12/ed4.12; N55e11/+ flies have an increased number of sensillum precursor cells specified. In many instances these sensillum precursor cells divide to produce four neurons rather than the wild type external sensory organ. ed4.12/ed4.12; Dlunspecified/+ flies have additional shaft (trichogen) cells The increased bristle number in ed4.12; scaBP2 double homozygotes is consistent with an additive rather than a synergistic effect of the two muations.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Selected as: a modifier of the rough eye phenotype caused by expression of atoScer\UAS.cJa under the control of Scer\GAL4sca-109-68.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
E(ato109-68)4.12
ed4.12
Name Synonyms
Secondary FlyBase IDs
    References (2)