FB2025_01 , released February 20, 2025
Allele: Dmel\cnoRA1mut+RA2mut.UAS
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General Information
Symbol
Dmel\cnoRA1mut+RA2mut.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0152062
Feature type
allele
Associated gene
Dmel\cno
Associated Insertion(s)
Carried in Construct
P{UAS-cno.RA1*+RA2*}
Key Links
Transgenic product class
missense_variant
(Boettner et al., 2003)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Boettner et al., 2003)
Mutagen
in vitro construct
(Boettner et al., 2003)
Progenitor genotype
Carried in construct
P{UAS-cno.RA1*+RA2*}
Cytology
Description

UASt regulatory sequences drive expression of a mutated form of cno (carries the amino acid replacements K57L and K274L).

(Boettner et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
cno
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4ptc-559.1/cnoRA1mut+RA2mut.UAS partially rescues cno2

      (Boettner et al., 2003)
      Comments

      Expression of cnoRA1mut+RA2mut.Scer\UAS under the control of Scer\GAL4ptc-559.1 partially rescues the dorsal closure defects of cno2 embryos, although the ability of cnoRA1mut+RA2mut.Scer\UAS to rescue is modestly reduced compared to the ability of cnoScer\UAS.cBa to rescue; 75% of embryos rescued by cnoRA1mut+RA2mut.Scer\UAS show a closed cuticle compared to 92% of embryos rescued by cnoScer\UAS.cBa.

      (Boettner et al., 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      cnoRA1mut+RA2mut.Scer\UAS
      cnoRA1mut+RA2mut.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)