A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Allele Dmel\Sin3Ae374

General Information
SymbolDmel\Sin3Ae374SpeciesD. melanogaster
NameFlyBase IDFBal0152186
Feature typealleleAssociated geneDmel\Sin3A
Allele class
Mutagen
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Description
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FB2013_03
FB2013_02
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Progenitor genotype
Nature of the lesion
Statement
Reference
8bp deletion approximately 50bp downstream of the Sin3A translation initiation codon.
(Pile et al., 2001)
Cytology
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hide Phenotypic Class
lethal | recessive
(Spain et al., 2010)
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Statement
Reference
Heterozygotes raised on medium containing trichostatin A (TSA) do not show an increase in the rate of lethality or developmental delay compared to wild-type flies raised on medium containing TSA.
(Pile et al., 2001)
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Statement
Reference
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Statement
Reference
hide Complementation & Rescue Data
Partially rescued by
Sin3Ae374 is partially rescued by Sin3A220.Scer\UAS.T:Ivir\HA1/Scer\GAL4αTub84B.PL
(Spain et al., 2010)
Sin3Ae374 is partially rescued by Sin3A220.Scer\UAS.T:Ivir\HA1/Sin3A187.Scer\UAS.T:Ivir\HA1/Scer\GAL4αTub84B.PL
(Spain et al., 2010)
Not rescued by
Sin3Ae374 is not rescued by Sin3A187.Scer\UAS.T:Ivir\HA1/Scer\GAL4αTub84B.PL
(Spain et al., 2010)
Comments
The lethality of Sin3A[e374] homozygotes is not rescued by expression of Sin3A[187.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[αTub84B.PL]. The lethality of Sin3A[e374] homozygotes is partially rescued by expression of Sin3A[220.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[αTub84B.PL] (66% viability). The lethality of Sin3A[e374] homozygotes is partially rescued by co-expression of both Sin3A[187.Scer\UAS.T:Ivir\HA1] and Sin3A[220.Scer\UAS.T:Ivir\HA1] under the control of Scer\GAL4[αTub84B.PL] (81% viability).
(Spain et al., 2010)
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Reported As
Symbol Synonym
dSin3Ae374
(Biryukova and Heitzler, 2008)
sin3e374
(Pile et al., 2001)
Sin3Ae374
(Spain et al., 2010)
Name Synonym
Secondary FlyBase IDs
hide References ( 3 )
Research paper
Spain et al., 2010, J. Biol. Chem. 285(35): 27457--27467
Drosophila SIN3 isoforms interact with distinct proteins and have unique biological functions. [FBrf0211588]
Biryukova and Heitzler, 2008, Dev. Biol. 323(1): 64--75
Drosophila C-terminal binding protein, dCtBP is required for sensory organ prepattern and sharpens proneural transcriptional activity of the GATA factor Pnr. [FBrf0207210]
Pile et al., 2001, Cell. Molec. Life Sci. 58(11): 1715--1718
The histone deacetylase inhibitor trichostatin A influences the development of Drosophila melanogaster. [FBrf0141421]