FB2025_01 , released February 20, 2025
Allele: Dmel\AtpαDTS1R1
Open Close
General Information
Symbol
Dmel\AtpαDTS1R1
Species
D. melanogaster
Name
FlyBase ID
FBal0152777
Feature type
allele
Associated gene
Dmel\Atpα
Associated Insertion(s)
Carried in Construct
Also Known As
ATPalphaDTS1R1
Key Links
Allele class

loss of function allele

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Ashmore et al., 2009)

loss of function allele

(Palladino et al., 2003)
Mutagen
gamma ray
(Palladino et al., 2003)
Progenitor genotype
AtpαDTS1
(Palladino et al., 2003)
Cytology
Description

Atpα protein expression levels are reduced in heterozygotes.

(Ashmore et al., 2009)

AtpαDTS1R1 has a 4 bp deletion (from 2713-2716) that results in a frameshift mutation predicted to cause premature truncation of the Atpα protein, if any product is made.

(Palladino et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  familial hemiplegic migraine
      CEA
      (Ashmore et al., 2009)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class

      abnormal locomotor behavior | dominant

      (Ashmore et al., 2009)

      abnormal neuroanatomy | dominant

      (Ashmore et al., 2009)

      bang sensitive (with AtpαCJ7)

      (Ashmore et al., 2009)

      bang sensitive | dominant

      (Palladino et al., 2003)

      bang sensitive | dominant | progressive

      (Ashmore et al., 2009)

      lethal

      (Ashmore et al., 2009)

      lethal (with AtpαCJ4)

      (Ashmore et al., 2009)

      lethal (with AtpαCJ5)

      (Ashmore et al., 2009)

      lethal (with AtpαCJ6)

      (Ashmore et al., 2009)

      lethal (with AtpαCJ10)

      (Ashmore et al., 2009)

      lethal (with AtpαCJ12)

      (Ashmore et al., 2009)

      lethal (with AtpαCJ13)

      (Ashmore et al., 2009)

      lethal (with AtpαDTS2R3)

      (Ashmore et al., 2009)

      lethal - all die during embryonic stage

      (Palladino et al., 2003)

      lethal - all die during embryonic stage (with Atpα01453a)

      (Palladino et al., 2003)

      lethal - all die during embryonic stage (with Atpα2206)

      (Palladino et al., 2003)

      lethal - all die during embryonic stage (with AtpαDTS1)

      (Palladino et al., 2003)

      lethal - all die during embryonic stage (with AtpαDTS1R2)

      (Palladino et al., 2003)

      lethal - all die during embryonic stage (with AtpαDTS2)

      (Palladino et al., 2003)

      lethal - all die during embryonic stage (with AtpαDTS2R1)

      (Palladino et al., 2003)

      lethal - all die during embryonic stage (with AtpαDTS2R2)

      (Palladino et al., 2003)

      lethal - all die during embryonic stage (with AtpαDTS2R3)

      (Palladino et al., 2003)

      lethal - all die during embryonic stage (with AtpαH64)

      (Palladino et al., 2003)

      long lived | dominant

      (Ashmore et al., 2009)

      paralytic | dominant

      (Palladino et al., 2003)

      some die during embryonic stage

      (Palladino et al., 2003)

      some die during embryonic stage (with Atpα01453a)

      (Palladino et al., 2003)

      some die during embryonic stage (with Atpα2206)

      (Palladino et al., 2003)

      some die during embryonic stage (with AtpαDTS1)

      (Palladino et al., 2003)

      some die during embryonic stage (with AtpαDTS1R2)

      (Palladino et al., 2003)

      some die during embryonic stage (with AtpαDTS2)

      (Palladino et al., 2003)

      some die during embryonic stage (with AtpαDTS2R1)

      (Palladino et al., 2003)

      some die during embryonic stage (with AtpαDTS2R2)

      (Palladino et al., 2003)

      some die during embryonic stage (with AtpαDTS2R3)

      (Palladino et al., 2003)

      some die during embryonic stage (with AtpαH64)

      (Palladino et al., 2003)
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heterozygous adults are long lived, as compared to controls.

      (Ashmore et al., 2009)

      AtpαDTS1R1 homozygous embryos have tracheal system defects including increased tube length, and ganglionic branch defects, but have only mild tube diameter increases.

      (Paul et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Palladino

      (Paul et al., 2003)

      Revertant.

      (Palladino et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      ATPalphaDTS1R1
      (Liu et al., 2012, Ashmore et al., 2009)
      ATPα DTS1 R1B
      (Gautam et al., 2015)
      AtpαDTS1R1
      DTS1R1
      (Palladino et al., 2003)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)