Allele Dmel\sax³

General Information
Symbol	Dmel\sax³	Species	D. melanogaster
Name		FlyBase ID	FBal0154657
Feature type	allele	Associated gene	Dmel\sax

Map ( GBrowse )
Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Twombly et al., 2009)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 2R:3,695,306..3,695,306 na_change=C3695306T reported_na_change=C?T pr_change=Q121 \| sax-PA; Q86 \| sax-PB; Q133@ \| sax-PC reported_pr_change=Q121@ (Twombly et al., 2009)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: Q121@. (Twombly et al., 2009) A premature stop codon in the extracellular domain. (Twombly et al., 2009)
Cytology
Phenotypic Data
Phenotypic Class
	developmental rate defective \| larval stage (with Df(2R)H23) (Twombly et al., 2009) lethal (with Df(2R)H23) (Twombly et al., 2009) lethal (with Df(2R)sax^1rv2) (Twombly et al., 2009) lethal (with Df(2R)sax-H9) (Twombly et al., 2009) lethal (with sax^1rv1) (Twombly et al., 2009) lethal (with sax^1rv5) (Twombly et al., 2009) lethal (with sax⁵) (Twombly et al., 2009) lethal (with sax⁶) (Twombly et al., 2009) lethal \| larval stage (with sax⁴) (Twombly et al., 2009) lethal \| maternal effect (with Df(2R)H23) (Twombly et al., 2009) lethal \| maternal effect (with Df(2R)sax-H9) (Twombly et al., 2009) lethal \| P-stage (with sax⁴) (Twombly et al., 2009) partially lethal - majority die (with sax^P) (Twombly et al., 2009) size defective \| larval stage (with Df(2R)H23) (Twombly et al., 2009) viable (with sax¹) (Twombly et al., 2009) viable (with sax²) (Twombly et al., 2009)
Phenotype Manifest In
	brain \| larval stage (with Df(2R)H23) (Twombly et al., 2009) egg \| maternal effect (with Df(2R)H23) (Twombly et al., 2009) egg \| maternal effect (with Df(2R)sax-H9) (Twombly et al., 2009) imaginal disc (with Df(2R)H23) (Twombly et al., 2009) trachea \| larval stage (with Df(2R)H23) (Twombly et al., 2009) wing vein (with Df(2R)H23) (Twombly et al., 2009) wing vein (with Df(2R)sax-H9) (Twombly et al., 2009)
Detailed Description
	Statement Reference sax[3] exhibits a very low level of viability (0.6-2%) in trans to Df(2R)H23, sax[1rv1], sax[1rv5] and Df(2R)sax-H9. Hemizygous adult escapers display wing venation defects (50% penetrance), while females display 100% maternal effect lethality with severely reduced egg production. Less than 5% of sax[3]/Df(2R)H23 hemizygous mutant larvae exhibit developmental delay, lethargy, a reduction in the size of imaginal discs, brain \| larval stage, and midgut structures, as well as trachea \| larval stagel truncations. (Twombly et al., 2009)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference When dpp[hr4]/+ males are crossed to sax[3]/+ females, the resulting dpp[hr4]/+ progeny do not show any significant drop in viability compared to the dpp[hr4]/+ progeny of wild-type mothers in control crosses. (Twombly et al., 2009)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	sax³/Df(2R)sax-H9 is rescued by sax^hs.PB (Twombly et al., 2009)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	sax³ (Twombly et al., 2009)
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Twombly et al., 2009, Genetics 183(2): 563--579 Functional analysis of saxophone, the Drosophila gene encoding the BMP type I receptor ortholog of human ALK1/ACVRL1 and ACVR1/ALK2. [FBrf0209213] Marques et al., 2003, Development 130(22): 5457--5470 Retrograde Gbb signaling through the Bmp type 2 receptor wishful thinking regulates systemic FMRFa expression in Drosophila. [FBrf0167500]

Allele Dmel\sax3

Allele Dmel\sax³