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General Information
Symbol
Dmel\pita1
Species
D. melanogaster
Name
FlyBase ID
FBal0154756
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

C23549729T

Amino acid change:

H472Y | pita-PA; H412Y | pita-PB

Reported amino acid change:

H472Y

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: H472Y.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

nurse cell & nucleus | germ-line clone

nurse cell & polytene chromosome | germ-line clone

Detailed Description
Statement
Reference

pita1 homozygotes die as larvae with melanotic 'tumors'. Imaginal disc development appears normal in these animals. At stage 10 the nurse cell nuclei of pita1 germ-line clone egg chambers show crater-like structures. At early stages some of these egg chambers lack nurse cell nuclei completely (25% n=420). This correlates with ectopic expression of cell-death markers in nurse cells. At subsequent stages the dumping of the nurse cell cytoplasm into the egg fails in 80% of egg chambers (n=460). Nurse cell polytene chromosomes fail to disperse after stage 5 (as in wild-type), but instead remain visible as discrete individualized blobs throughout late stages.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
pita1
Name Synonyms
Secondary FlyBase IDs
    References (2)