FlyBase Allele Report: Dmel\gpp[XXV]

General Information

Symbol

Dmel\gpp^XXV

Species

D. melanogaster

Name

FlyBase ID

FBal0155220

Feature type

allele

Associated gene

Dmel\gpp

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Nil et al., 2023)

Mutagen

X ray

(Shanower et al., 2005)

Progenitor genotype

Caused by aberration

In(3R)gpp^XXV

Cytology

Description

Breakpoint in the coding region of gpp.

(Shanower et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of syndromic intellectual disability

CEA

(Nil et al., 2023)

CEA with gpp^{CR70526-TG4.1}

(Nil et al., 2023)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Song et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate (with gpp^{CR70526-TG4.1})

(Nil et al., 2023)

lethal (with Df(3R)WIN11)

(Shanower et al., 2005)

lethal (with gpp⁸)

(Shanower et al., 2005)

lethal (with gpp^61A)

(Shanower et al., 2005)

lethal (with gpp^IN1)

(Shanower et al., 2005)

lethal (with gpp^X)

(Shanower et al., 2005)

lethal - all die during larval stage (with Df(3R)BSC193)

(Nil et al., 2023)

lethal - all die during larval stage (with gpp^{CR70526-TG4.1})

(Nil et al., 2023)

lethal - all die during larval stage | recessive

(Nil et al., 2023)

non-enhancer of variegation, with P{hsp26-pt-T}39C-4

(Shanower et al., 2005)

non-enhancer of variegation, with P{hsp26-pt-T}118E-10

(Shanower et al., 2005)

non-enhancer of variegation, with P{hsp26-pt-T}118E-12

(Shanower et al., 2005)

non-suppressor of variegation, with P{hsp26-pt-T}39C-4

(Shanower et al., 2005)

non-suppressor of variegation, with P{hsp26-pt-T}118E-10

(Shanower et al., 2005)

non-suppressor of variegation, with P{hsp26-pt-T}118E-12

(Shanower et al., 2005)

suppressor of variegation, with P{hsp26-pt-T}39C-27

(Shanower et al., 2005)

suppressor of variegation, with P{hsp26-pt-T}39C-31

(Shanower et al., 2005)

suppressor of variegation, with P{hsp26-pt-T}39C-50

(Shanower et al., 2005)

suppressor of variegation, with P{hsp26-pt-T}39C-55

(Shanower et al., 2005)

suppressor of variegation, with P{hsp26-pt-T}39C-62

(Shanower et al., 2005)

suppressor of variegation, with P{hsp26-pt-T}39C-72

(Shanower et al., 2005)

suppressor of variegation, with P{hsp26-pt-T}Dyrk3^118E-15

(Shanower et al., 2005)

suppressor of variegation | partially, with P{hsp26-pt-T}39C-5

(Shanower et al., 2005)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

gpp[+]/gpp^XXV is an enhancer of sex comb | ectopic phenotype of Pcl¹⁰

(Shanower et al., 2005)

gpp[+]/gpp^XXV is an enhancer of sex comb | ectopic phenotype of Scm^D1

(Shanower et al., 2005)

gpp[+]/gpp^XXV is an enhancer of sex comb | ectopic phenotype of Pc³

(Shanower et al., 2005)

gpp[+]/gpp^XXV is an enhancer of sex comb | ectopic phenotype of Sce¹

(Shanower et al., 2005)

Suppressor of

Statement

Reference

gpp[+]/gpp^XXV is a suppressor of wing vein | ectopic phenotype of Snr1^E1

(Marenda et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

gpp^XXV weakly suppresses the pairing-sensitive silencing seen in flies carrying P{Mcp-ff#13}101 and P{Mcp-w#14}AP-2^stummelbein in cis or P{Mcp-w#11}16 and P{Mcp-w#11}102 in cis but does not suppress the pairing-sensitive silencing seen in flies carrying P{Mcp-wy#2}63 and P{Mcp-ff#15}30 in cis.

(Shanower et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

42231

In(3R)gpp^XXV, gpp^XXV/TM3, P{ActGFP}JMR2, Ser¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

gpp^XXV

(Song et al., 2018)

gpp^xxv

(Nil et al., 2023)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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