FlyBase Allele Report: Dmel\EndoA[UAS.cVa]

General Information

Symbol

Dmel\EndoA^UAS.cVa

Species

D. melanogaster

Name

FlyBase ID

FBal0155327

Feature type

allele

Associated gene

Dmel\EndoA

Associated Insertion(s)

Carried in Construct

P{UAS-endo.V}

Key Links

Transgenic product class

wild_type

(Verstreken et al., 2003)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Verstreken et al., 2003)

Mutagen

in vitro construct

(Verstreken et al., 2003)

Progenitor genotype

Carried in construct

P{UAS-endo.V}

Cytology

Description

UAS sequences drive expression of EndoA.

(Verstreken et al., 2003)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

EndoA

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^2xAPP.SP.UAS

(Yu et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

EndoA^UAS.cVa, Scer\GAL4^{elav.Switch.PO} is an enhancer of short lived | RU486 conditional phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

EndoA^UAS.cVa, Scer\GAL4^{elav.Switch.PO} is an enhancer of abnormal locomotor behavior | RU486 conditional phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO}

(Yu et al., 2020)

EndoA^UAS.cVa, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PF

(Buff et al., 2007)

EndoA^UAS.cVa/Scer\GAL4^ey.PH is an enhancer of abnormal neuroanatomy phenotype of Synj¹

(Verstreken et al., 2003)

EndoA^UAS.cVa/Scer\GAL4^ey.PH is an enhancer of abnormal neuroanatomy phenotype of Synj²

(Verstreken et al., 2003)

Suppressor of

Statement

Reference

Scer\GAL4^Toll-6-D42/EndoA^UAS.cVa is a suppressor of abnormal neurophysiology | dominant | third instar larval stage phenotype of Vps35^MH20

(Inoshita et al., 2017)

EndoA^UAS.cVa/Scer\GAL4^ey.PH is a suppressor of abnormal neurophysiology phenotype of Synj¹

(Verstreken et al., 2003)

EndoA^UAS.cVa/Scer\GAL4^ey.PH is a suppressor of abnormal neurophysiology phenotype of Synj²

(Verstreken et al., 2003)

Phenotype Manifest In

Enhancer of

Statement

Reference

EndoA^UAS.cVa, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PF

(Buff et al., 2007)

EndoA^UAS.cVa/Scer\GAL4^ey.PH is an enhancer of synaptic vesicle phenotype of Synj¹

(Verstreken et al., 2003)

EndoA^UAS.cVa/Scer\GAL4^ey.PH is an enhancer of synaptic vesicle phenotype of Synj²

(Verstreken et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

The expression of EndoA^Scer\UAS.cVa under the control of Scer\GAL4^Toll-6-D42 fully suppresses the decreased excitatory junction potential amplitude under high stimulation conditions observed at the third instar larval neuromuscular junction of Vps35^MH20 heterozygotes.

(Inoshita et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

26690

y¹ w^*; P{UAS-endo.V}I-III

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

EndoA^Scer\UAS.cVa

EndoA^UAS.cVa

endoA^Scer\UAS.cVa

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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