Allele Dmel\crol^unspecified

General Information
Symbol	Dmel\crol^unspecified	Species	D. melanogaster
Name		FlyBase ID	FBal0155430
Feature type	allele	Associated gene	Dmel\crol

Allele class
Mutagen
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	cell death defective, with Scer\GAL4^ey.PH (Schneiderman et al., 2010)
Phenotype Manifest In
	morphogenetic furrow, with Scer\GAL4^ey.PH (Schneiderman et al., 2010)
Detailed Description
	Statement Reference Over-expression of crol[unspecified] driven by Scer\GAL4[ey.PH] causes a substantial increase in the number of mitotic cells on both sides of the morphogenetic furrow. This is accompanied by increased cell death in these zones. (Schneiderman et al., 2010)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference Scer\GAL4^GMR.PF, bw^D, crol^unspecified has eye color defective \| dominant phenotype, suppressible by Hsap\CDKN1A^GMR.PH (Schneiderman et al., 2010)
Other
Statement Reference CycB[+]/CycB², Scer\GAL4^unspecified, bw^D, crol^unspecified has eye color defective \| dominant phenotype (Schneiderman et al., 2010) E(zip)12-5^12-5, crol^unspecified has viable phenotype (Bayer et al., 2003, Bayer et al., 2003) E(zip)18-5^18-5, crol^unspecified has viable phenotype (Bayer et al., 2003, Bayer et al., 2003) E(zip)31-6^31-6, crol^unspecified has viable phenotype (Bayer et al., 2003, Bayer et al., 2003)
Phenotype Manifest In
Suppressed by
Statement Reference Scer\GAL4^GMR.PF, bw^D, crol^unspecified has eye phenotype, suppressible by Hsap\CDKN1A^GMR.PH (Schneiderman et al., 2010)
Other
Statement Reference CG8036^LA3.2, Scer\GAL4^unspecified, bw^D, crol^unspecified has eye phenotype (Schneiderman et al., 2010) CycB[+]/CycB², Scer\GAL4^unspecified, bw^D, crol^unspecified has eye phenotype (Schneiderman et al., 2010) Scer\GAL4^unspecified, bw^D, crol^unspecified, jim^LA3.1 has eye phenotype (Schneiderman et al., 2010) Scer\GAL4^unspecified, Ubp64E^LA5.3, bw^D, crol^unspecified has eye phenotype (Schneiderman et al., 2010)
Additional Comments
Genetic Interactions
Statement Reference CycB[2] dominantly reduces the area of sectors of increased pigmentation in a bw[D]/+ genetic background resulting from the over-expression of crol[unspecified] driven by Scer\GAL4[unspecified]. Contemporaneous expression of jim[LA3.1] with crol[unspecified] driven by Scer\GAL4[unspecified] reduces the size and frequency of sectors of increased pigmentation in a bw[D]/+ genetic background, but the background speckled variegation remains unchanged. Contemporaneous expression of CG8036[LA3.2] with crol[unspecified] driven by Scer\GAL4[unspecified] reduces the size and frequency of sectors of increased pigmentation in a bw[D]/+ genetic background, but the background speckled variegation remains unchanged. Contemporaneous expression of CG10630[LA4.4] with crol[unspecified] driven by Scer\GAL4[unspecified] reduces the size and frequency of sectors of increased pigmentation in a bw[D]/+ genetic background, but the background speckled variegation remains unchanged. Contemporaneous expression of Ubp64E[LA5.3] with crol[unspecified] driven by Scer\GAL4[unspecified] increases the size or frequency of sectors of increased pigmentation in a bw[D]/+ genetic background, but the background speckled variegation remains unchanged. (Schneiderman et al., 2010) Double heterozygotes with E(zip)12-5^12-5, E(zip)18-5^18-5 or E(zip)31-6^31-6 are fully viable and have wild-type leg morphology. (Bayer et al., 2003)
Xenogenetic Interactions
Statement Reference The increased eye pigmentation in bw[D]/+ heterozygotes resulting from the mis-expression of crol[unspecified] driven by Scer\GAL4[GMR.PF] is suppressed by Hsap\CDKN1A[GMR.PH]. (Schneiderman et al., 2010)
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	crol^unspecified
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Schneiderman et al., 2010, PLoS Genet. 6(9): e1001095 Perturbation Analysis of Heterochromatin-Mediated Gene Silencing and Somatic Inheritance. [FBrf0211786] Bayer et al., 2003, Genetics 165(3): 1417--1432 Genetic interactions between the RhoA and Stubble-stubbloid loci suggest a role for a type II transmembrane serine protease in intracellular signaling during Drosophila imaginal disc morphogenesis. [FBrf0167640]

Allele Dmel\crolunspecified

Allele Dmel\crol^unspecified