Allele Dmel\babo^{A.ΔI.Scer\UAS}

General Information
Symbol	Dmel\babo^{A.ΔI.Scer\UAS}	Species	D. melanogaster
Name		FlyBase ID	FBal0155622
Feature type	allele	Associated gene	Dmel\babo

Allele class
Mutagen	in vitro construct
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct (McCabe et al., 2003)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	babo^Scer\UAS.cBa (McCabe et al., 2003)
Nature of the lesion	Statement Reference Construct: The babo ORF of isoform A in babo^Scer\UAS.cBa from which a BglII/Asp718 fragment has been removed and replaced by a linker containing stop sites and an SpeI restriction site. (McCabe et al., 2003)
Carried in construct	P{UAS-babo.A.ΔI} (Parker et al., 2006)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective \| embryonic stage, with Scer\GAL4^elav-C155, babo^{B.ΔI.Scer\UAS} (Parker et al., 2006) neuroanatomy defective \| embryonic stage, with Scer\GAL4^Rapgap1-OK6, babo^{B.ΔI.Scer\UAS} (Parker et al., 2006)
Phenotype Manifest In
	abdominal segmental nerve, with Scer\GAL4^elav-C155, babo^{B.ΔI.Scer\UAS} (Parker et al., 2006) abdominal segmental nerve, with Scer\GAL4^Rapgap1-OK6, babo^{B.ΔI.Scer\UAS} (Parker et al., 2006) intersegmental nerve, with Scer\GAL4^elav-C155, babo^{B.ΔI.Scer\UAS} (Parker et al., 2006) intersegmental nerve, with Scer\GAL4^Mef2.PR, babo^{B.ΔI.Scer\UAS} (Parker et al., 2006) intersegmental nerve, with Scer\GAL4^Rapgap1-OK6, babo^{B.ΔI.Scer\UAS} (Parker et al., 2006)
Detailed Description
	Statement Reference Expression of babo^{A.ΔI.Scer\UAS} and babo^{B.ΔI.Scer\UAS} together in motorneurons, driven by Scer\GAL4^OK6, causes ISNb pathfinding defects and SNa branching defects. The more copies of babo^{A.ΔI.Scer\UAS} that are expressed, the higher the penetrance of the phenotype. This phenotype also occurs when babo^{A.ΔI.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155. Expression of babo^{A.ΔI.Scer\UAS} and babo^{B.ΔI.Scer\UAS} together in muscle, driven by Scer\GAL4^Mef2.PR, results in a low penetrance of weak ISNb defects and no SNa defects. When babo^{A.ΔI.Scer\UAS} and babo^{B.ΔI.Scer\UAS} are expressed together in glia, under the control of Scer\GAL4^repo, only 4% of hemisegments show ISNb pathfinding defects and 2% show SNa branching defects. (Parker et al., 2006)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Carried in plasmid "UAST-babo_AΔI", and expressed in S2 cells. (McCabe et al., 2003)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	babo^{A.ΔI.Scer\UAS}
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Parker et al., 2006, Development 133(24): 4981--4991 The divergent TGF-beta ligand Dawdle utilizes an activin pathway to influence axon guidance in Drosophila. [FBrf0194818] McCabe et al., 2003, Neuron 39(2): 241--254 The BMP homolog Gbb provides a retrograde signal that regulates synaptic growth at the Drosophila neuromuscular junction. [FBrf0160784]

Allele Dmel\baboA.ΔI.Scer\UAS

Allele Dmel\babo^{A.ΔI.Scer\UAS}