FlyBase Allele Report: Dmel\armi[1]

General Information

Symbol

Dmel\armi¹

Species

D. melanogaster

Name

FlyBase ID

FBal0155637

Feature type

allele

Associated gene

Dmel\armi

Associated Insertion(s)

P{lacW}armi¹

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{lacW}armi¹

Cytology

Description

Insertion in the 5' UTR of armi.

(Cook et al., 2004)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of primary ovarian insufficiency

CEA

(Bestetti et al., 2021)

CEA with armi^KG04664

(Bestetti et al., 2021)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile

(Cook et al., 2004)

lethal - all die during embryonic stage | maternal effect (with armi^72.1)

(Orsi et al., 2010)

male semi-fertile (with armi^72.1)

(Venkei et al., 2023)

male semi-sterile

(Tomari et al., 2004)

some die during embryonic stage | maternal effect (with armi^72.1)

(Orsi et al., 2010)

Phenotype Manifest In

dorsal appendage (with armi^72.1)

(Orsi et al., 2010, Klattenhoff et al., 2007)

dorsal appendage | maternal effect

(Cook et al., 2004, Tomari et al., 2004)

dorsal appendage | maternal effect (with armi^72.1)

(Klattenhoff et al., 2009)

microtubule organizing center & oocyte (with armi^72.1)

(Klattenhoff et al., 2007)

Detailed Description

Statement

Reference

Newly eclosed armi¹/armi^72.1 transheterozygous females do not show any obvious changes in the number of germ line stem cells in the germarium, as compared to controls.

(Ma et al., 2014)

Eggs laid by armi¹/armi^72.1 females have dorsal appendage defects; 11.7% have fused dorsal appendages, 88.1% lack dorsal appendages and 0.2% have wild-type dorsal appendages.

(Orsi et al., 2010)

Only 2% of eggs derived from armi¹/armi^72.1 females have two wild-type dorsal appendages, compared with 11% if the females are fed caffeine.

(Klattenhoff et al., 2009)

armi^72.1/armi¹ eggs show fused appendages in 67.6% of cases, no appendages in 28.9% of cases and the wild-type number of appendages in 3.5% of cases.

In armi^72.1/armi¹ oocytes, both the anterior and later posterior microtubule-organizing centers are much less prominent than in wild-type oocytes.

(Klattenhoff et al., 2007)

Homozygous females produce eggs where 67% completely lack dorsal appendages (indicating strong dorsal/ventral patterning defects).

(Cook et al., 2004)

75% of progeny derived from homozygous males mated to wild-type females hatch. 67% of eggs derived from armi¹ females lack dorsal appendages, while some of the eggs have wild-type or partially fused dorsal appendages.

(Tomari et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

armi^72.1/armi¹ has lethal | maternal effect | embryonic stage phenotype, non-suppressible by lok^p6/lok^p6

(Orsi et al., 2010)

Phenotype Manifest In

Suppressed by

Statement

Reference

armi^72.1/armi¹ has dorsal appendage phenotype, suppressible | partially by lok^p6/lok^p6

(Orsi et al., 2010)

armi^72.1/armi¹ has dorsal appendage | maternal effect phenotype, suppressible | partially by mei-41^D3/mei-41^D3

(Klattenhoff et al., 2009)

armi^72.1/armi¹ has dorsal appendage phenotype, suppressible by lok^p6/lok^p6

(Klattenhoff et al., 2007)

armi^72.1/armi¹ has dorsal appendage phenotype, suppressible | partially by mei-41^D3/mei-41^D3

(Klattenhoff et al., 2007)

armi^72.1/armi¹ has microtubule organizing center & oocyte phenotype, suppressible by lok^p6/lok^p6

(Klattenhoff et al., 2007)

armi^72.1/armi¹ has microtubule organizing center & oocyte phenotype, suppressible by mei-41^D3/mei-41^D3

(Klattenhoff et al., 2007)

NOT suppressed by

Statement

Reference

armi^72.1/armi¹ has dorsal appendage phenotype, non-suppressible by mei-W68¹/mei-W68^k05603

(Klattenhoff et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

The dorsal appendage defects seen in eggs laid by armi¹/armi^72.1 females are partly suppressed if the females are also homozygous for lok^p6; 16.1% of the eggs have fused dorsal appendages, 7.3% lack dorsal appendages and 76.6% have wild-type dorsal appendages.

(Orsi et al., 2010)

56% of eggs derived from mei-41^D3/mei-41^D3 ; armi¹/armi^72.1 double mutant females have normal dorsal appendages, but the fraction of embryos with normal dorsal appendages increases to 83% if the females are fed caffeine.

(Klattenhoff et al., 2009)

The fused dorsal appendage phenotype of armi^72.1/armi¹ eggs is suppressed in lok^p6; armi^72.1/armi¹ eggs with 92% of double mutants showing wild-type appendage morphology.

The mei-41^D3 mutation partially suppresses the fused dorsal appendage phenotype of armi^72.1/armi¹ eggs; 56% of mei-41^D3; armi^72.1/armi¹ eggs show wild-type appendage morphology.

The fused dorsal appendage phenotype of armi^72.1/armi¹ eggs is not suppressed in mei-W68¹/mei-W68^k05603; armi^72.1/armi¹ eggs.

The microtubule-organizing center phenotype of armi^72.1/armi¹ oocytes is suppressed by the lok^p6 mutation.

The microtubule-organizing center phenotype of armi^72.1/armi¹ oocytes is partially suppressed by the mei-41^D3 mutation.

(Klattenhoff et al., 2007)

armi¹ osk¹ double mutant ovaries have microtubule defects that are cytologically identical to the armi single mutant phenotype.

(Cook et al., 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

armi^72.1/armi¹ is rescued by Scer\GAL4^{VP16.nanos.UTR}/armi^UASp.EGFP

(Venkei et al., 2023)

Partially rescued by

armi¹ is partially rescued by Scer\GAL4^nanos.PG/armi^UASp.EGFP

(Cook et al., 2004)

Not rescued by

armi^72.1/armi¹ is not rescued by armi^UASp.EGFP/Scer\GAL4^VP16.bam

(Venkei et al., 2023)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

8513

y¹ w^*; P{lacW}armi¹/TM3, Sb¹

Notes on Origin

Discoverer

Comments

Excision of the insertion can revert the mutant phenotype.

(Cook et al., 2004)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Name Synonyms

Secondary FlyBase IDs

References (24)

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