Allele Dmel\amos¹

General Information
Symbol	Dmel\amos¹	Species	D. melanogaster
Name		FlyBase ID	FBal0155657
Feature type	allele	Associated gene	Dmel\amos

Map ( GBrowse )
Allele class	loss of function allele
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	loss of function allele (zur Lage et al., 2003)
Mutagen	ethyl methanesulfonate (zur Lage et al., 2003)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 2L:18,596,357..18,596,357 evidence=experimental pr_change=Q184@\|amos-PA reported_na_change=C550T reported_pr_change=Q184@ na_change=C18596357T (zur Lage et al., 2003)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: Q184@. Nucleotide substitution: C550T. (zur Lage et al., 2003)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective \| embryonic stage (Grillenzoni et al., 2007) viable (zur Lage et al., 2003) viable (with Df(2L)M36F-S6) (zur Lage et al., 2003)
Phenotype Manifest In
	embryonic antennal sense organ (Grillenzoni et al., 2007) macrochaeta \| ectopic & antenna (zur Lage et al., 2003) macrochaeta \| ectopic & antenna (with Df(2L)M36F-S6) (zur Lage et al., 2003) olfactory neuron & embryonic antennal sense organ (Grillenzoni et al., 2007) sensillum basiconicum & antenna (zur Lage et al., 2003) sensillum basiconicum & antenna (with Df(2L)M36F-S6) (zur Lage et al., 2003) sensillum trichodeum of antennal segment 3 (zur Lage et al., 2003) sensillum trichodeum of antennal segment 3 (with Df(2L)M36F-S6) (zur Lage et al., 2003) sensory mother cell & antennal disc (zur Lage et al., 2003) sensory neuron \| dorsal (zur Lage et al., 2003)
Detailed Description
	Statement Reference The number of neurons in the dorsal organ ganglion are reduced in mutant embryos compared to wild type. The number of olfactory receptor neurons in the DO ganglion is reduced in the mutant embryos (average number is 12 compared to the wild-type number of 21). (Grillenzoni et al., 2007) Mutant embryos lack two dorsal sensory neurons per segment, including the dorsal bipolar dendritic neuron. Adults are viable as homozygotes and hemizygotes. In amos¹/Df(2L)M36F-S6 animals the third segment of the antenna is reduced because of missing basiconica and trichodea. In the pupal antennal imaginal disc of mutant animals, the first and second waves of sensory organ precursor formation appear to occur normally, but the third phase fails to occur. (zur Lage et al., 2003)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement Reference amos¹/Df(2L)M36F-S6 has macrochaeta \| ectopic & antenna phenotype, suppressible \| partially by sc^10-1 (zur Lage et al., 2003) amos¹/Df(2L)M36F-S6 has macrochaeta \| ectopic & antenna phenotype, suppressible by lz³⁴ (zur Lage et al., 2003)
Other
Statement Reference amos¹, ato¹ has sensory neuron \| somatic clone phenotype (zur Lage et al., 2003, zur Lage et al., 2003, zur Lage et al., 2003, zur Lage et al., 2003)
Additional Comments
Genetic Interactions
Statement Reference amos¹ ; ato¹ double mutant embryos show a complete lack of olfactory receptor neurons in the dorsal organ ganglion. (Grillenzoni et al., 2007) When amos¹ clones are made in ato¹ animals the clone patch contains no sense organs except bristles. (zur Lage et al., 2003)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Partially rescued by	amos¹/Df(2L)M36F-S6 is partially rescued by amos^Scer\UAS.cGa/Scer\GAL4^amos.PZ (Holohan et al., 2006)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	amos¹ (Grillenzoni et al., 2007, Holohan et al., 2006, Benton et al., 2009, Bardin et al., 2010, Plavicki et al., 2012)
Name Synonym
Secondary FlyBase IDs

References ( 6 )
Research paper	Plavicki et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(5): 1578--1583 Homeobox gene distal-less is required for neuronal differentiation and neurite outgrowth in the Drosophila olfactory system. [FBrf0217395] Bardin et al., 2010, Development 137(5): 705--714 Transcriptional control of stem cell maintenance in the Drosophila intestine. [FBrf0209974] Benton et al., 2009, Cell 136(1): 149--162 Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila. [FBrf0206496] Grillenzoni et al., 2007, Dev. Genes Evol. 217(3): 209--219 Role of proneural genes in the formation of the larval olfactory organ of Drosophila. [FBrf0193556] Holohan et al., 2006, BMC Dev. Biol. 6: 53 Multiple enhancers contribute to spatial but not temporal complexity in the expression of the proneural gene, amos. [FBrf0195219] zur Lage et al., 2003, Development 130(19): 4683--4693 The Drosophila proneural gene amos promotes olfactory sensillum formation and suppresses bristle formation. [FBrf0162077]

Allele Dmel\amos1

Allele Dmel\amos¹