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General Information
Symbol
Dmel\mrnEP3605
Species
D. melanogaster
Name
FlyBase ID
FBal0155762
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
EP3605
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion 20 nucleotides upstream of the predicted translation initiation codon.

Insertion components
P{EP}mrnEP3605
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

14% of mrnEP3605/mrn3 larvae have melanotic tumours. In addition, there is a highly reproducible and specific melanisation at the intersection between the midgut and posterior gut, in the imaginal ring region.

88% of mrnEP3605/mrn5 larvae have melanotic tumours. In addition, there is a highly reproducible and specific melanisation at the intersection between the midgut and posterior gut, in the imaginal ring region.

mrnEP3605/mrn1 larvae show general necrosis.

Heterozygous larvae are more sensitive to UVB irradiation compared to controls.

Homozygous pupae are smaller than controls. mrnEP3605/mrn3 adult escapers are smaller than controls.

Some homozygotes die at the pharate adult stage with deformations in the cuticle and a brittle bristle phenotype.

Early stages of oogenesis are normal but mature oocytes are deformed in homozygous females, apparently resulting from an aberrant chorion, and thus the eggs are not viable.

Aberrant egg chambers are seen in mrnEP3605/mrn1 and mrnEP3605/mrn3 females and pycnotic nuclei are seen in nurse cells.

mrnEP3605/mrn1 males have defective testes, and spermatogenesis is either absent or not completed in most cases.

Mitotic spreads of mrnEP3605/mrn1 and mrnEP3605/mrn5 larval neuroblasts show a high rate of chromosome aberrations, including fragmentation of chromosomes and partial chromosome condensation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
NOT suppressed by
Statement
Reference

mrnEP3605/mrn1 has sterile phenotype, non-suppressible by Hsap\GTF2H4Hsp83.PF

Phenotype Manifest In
Suppressed by
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The defective bristle and thin thorax and abdomen phenotypes seen in mrn5/mrnEP3605 adults are suppressed by Tfb5Hsp83.PAF.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Tfb2EP3605
mrnEP3605
Name Synonyms
Secondary FlyBase IDs
    References (5)