FlyBase Allele Report: Dmel\Sod2[UAS.cMa]

General Information

Symbol

Dmel\Sod2^UAS.cMa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct of Missirlis

FlyBase ID

FBal0155805

Feature type

allele

Associated gene

Dmel\Sod2

Associated Insertion(s)

Carried in Construct

P{UAS-Sod2.M}

Also Known As

UAS-Sod2, UAS-dSod2

Allele class

Mutagen

in vitro construct - regulatory fusion

Nature of the Allele

Allele class

Mutagen

in vitro construct - regulatory fusion

(Missirlis et al., 2003)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Carried in construct

P{UAS-Sod2.M}

Cytology

Nature of the lesion

Statement

Reference

UASt regulatory sequences drive expression of a full-length Sod2 cDNA.

(Missirlis et al., 2003)

Allele components

Product class / Tool use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Sod2

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by park²⁵

(Vincent et al., 2012)

ameliorates tauopathy

modeled by Hsap\MAPT^R406W.UAS

(Dias-Santagata et al., 2007)

exacerbates neurodegenerative disease

modeled by Zzzz\CAG^{Q48.UAS.Tag:MYC,Tag:FLAG}

(Underwood et al., 2010)

ameliorates Alzheimer's disease

modeled by Hsap\APP^{Arctic.UAS.Tag:SS(nec)}

(Rival et al., 2009)

ameliorates acute myeloid leukemia

modeled by Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa

(Sinenko et al., 2010)

ameliorates autosomal dominant cerebellar ataxia

modeled by tws^UAS.cBa

(Wang et al., 2011)

ameliorates cardiomyopathy

modeled by park^HMS01651

(Bhandari et al., 2014)

modeled by park^HMS01800

(Bhandari et al., 2014)

exacerbates mucopolysaccharidosis type IIIA

modeled by Sgsh^GD1578

(Webber et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

Global overexpression of Sod2 ameliorates the synaptic overgrowth phenotype but not the locomotion defects of park²⁵/park²⁵ larvae modelling Parkinson's disease.

(Vincent et al., 2012)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult heart, with Scer\GAL4^Ugt36A1.PK

(Lim et al., 2014)

lamellocyte | third instar larval stage | conditional, with Scer\GAL4^Antp-10

(Sinenko et al., 2011)

wing, with Scer\GAL4^rn-GAL4-5

(Khan et al., 2017)

Detailed Description

Statement

Reference

Adults expressing Sod2^UAS.cMa under the control of Scer\GAL4^elav.PLu exhibit progressive climbing defects compared to controls.

(Webber et al., 2018)

The size distribution of regenerated adult wings in flies expressing Sod2^Scer\UAS.cMa under the control of Scer\GAL4^rn-GAL4-5 that were subjected to ablation of imaginal wing disc tissue during the larval stage, is significantly shifted towards smaller wing size compared to similarly treated controls.

(Khan et al., 2017)

Expression of Sod2^Scer\UAS.cMa under the control of either Scer\GAL4^da.PU or Scer\GAL4^ple.PF does not affect the climbing ability of adult flies relative to controls.

(Filograna et al., 2016)

Expression of Sod2^Scer\UAS.cMa under the control of Scer\GAL4^tin.CΔ4 has no effect on heart tube contraction.

(Bhandari et al., 2014)

Expression of Sod2^Scer\UAS.cMa specifically in nonmyocytic pericardial cells, under the control of Scer\GAL4^Dot.PK increases the incidence of cardiac arrhythmia and causes constriction of the heart tube.

(Lim et al., 2014)

Expression of Sod2^Scer\UAS.cMa under the control of Scer\GAL4^Antp-10 has no effect on lamellocyte number in unstressed conditions, but is able to reduce the increase in lamellocyte number seen following wasp infestation.

(Sinenko et al., 2011)

Expression of Sod2^Scer\UAS.cMa under the control of Scer\GAL4^Hml.Δ does not significantly affect hemocyte proliferation in third instar larvae.

(Sinenko et al., 2010)

Expression of Sod2^Scer\UAS.cMa under the control of Scer\GAL4^da.G32 or Scer\GAL4^Mhc.PW does not result in an increased resistance to paraquat.

(Missirlis et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^Ugt36A1.PK, Sod2^UAS.cMa has oxidative stress response defective phenotype, enhanceable by Scer\GAL4^Hand.PA/Sod1^UAS.cWa

(Lim et al., 2014)

Enhancer of

Statement

Reference

Sod2^UAS.cMa/Scer\GAL4^elav.PLu is an enhancer of locomotor behavior defective | adult stage | progressive phenotype of Scer\GAL4^elav.PLu, Sgsh^GD1578

(Webber et al., 2018)

Sod2^UAS.cMa/Scer\GAL4^Hand.PA is an enhancer of oxidative stress response defective phenotype of Scer\GAL4^Ugt36A1.PK, Sod1^UAS.cWa

(Lim et al., 2014)

Sod2^UAS.cMa/Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, Zzzz\CAG^{Q48.UAS.Tag:MYC,Tag:FLAG}

(Underwood et al., 2010)

Suppressor of

Statement

Reference

Sod2^UAS.cMa, Scer\GAL4^Tub.PU is a suppressor | partially of short lived phenotype of Adck1^NIG.3608R, Scer\GAL4^Tub.PU

(Yoon et al., 2019)

Scer\GAL4^da.PU/Sod2^UAS.cMa is a suppressor of neuroanatomy defective | progressive phenotype of YME1L^del

(Qi et al., 2016)

Scer\GAL4^da.PU/Sod2^UAS.cMa is a suppressor | partially of locomotor behavior defective | progressive phenotype of YME1L^del

(Qi et al., 2016)

Scer\GAL4^da.PU/Sod2^UAS.cMa is a suppressor of short lived phenotype of YME1L^del

(Qi et al., 2016)

Scer\GAL4^Act5C.PU/Sod2^UAS.cMa is a suppressor of neuroanatomy defective | recessive | third instar larval stage phenotype of park²⁵

(Vincent et al., 2012)

Sod2^UAS.cMa/Scer\GAL4^Mef2.PR is a suppressor | partially of partially lethal - majority die phenotype of p38a¹, p38b^Δ25

(Vrailas-Mortimer et al., 2011)

Sod2^UAS.cMa/Scer\GAL4^Mef2.PR is a suppressor of short lived phenotype of p38b^Δ45

(Vrailas-Mortimer et al., 2011)

Scer\GAL4^elav.PU/Sod2^UAS.cMa is a suppressor of short lived | heat sensitive phenotype of Scer\GAL4^elav.PU, tws^UAS.cBa

(Wang et al., 2011)

Sod2^UAS.cMa, Scer\GAL4^Hml.Δ is a suppressor | partially of increased cell number | third instar larval stage phenotype of Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Sod2^UAS.cMa, Scer\GAL4^elav-C155 is a suppressor of short lived phenotype of Hsap\APP^{Arctic.UAS.Tag:SS(nec)}, Scer\GAL4^elav-C155

(Rival et al., 2009)

Sod2^UAS.cMa, Scer\GAL4^elav-C155 is a suppressor of locomotor behavior defective phenotype of Hsap\APP^{Arctic.UAS.Tag:SS(nec)}, Scer\GAL4^elav-C155

(Rival et al., 2009)

Sod2^UAS.cMa, Scer\GAL4^elav.PU is a suppressor | partially of neuroanatomy defective | adult stage phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

Sod2^UAS.cMa, Scer\GAL4^elav.PU is a suppressor | partially of increased cell death | adult stage phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

NOT Suppressor of

Statement

Reference

Sod2^UAS.cMa/Scer\GAL4^ninaE.PT is a non-suppressor of neurophysiology defective | somatic clone | adult stage phenotype of fh¹

(Chen et al., 2016)

Sod2^UAS.cMa/Scer\GAL4^Mef2.PR is a non-suppressor of locomotor behavior defective | third instar larval stage phenotype of Scer\GAL4^Mef2.PR, clu^GD13926

(Wang et al., 2016)

Sod2^UAS.cMa/Scer\GAL4^Mef2.PR is a non-suppressor of partially lethal - majority die phenotype of Scer\GAL4^Mef2.PR, clu^GD13926

(Wang et al., 2016)

Scer\GAL4^Act5C.PU/Sod2^UAS.cMa is a non-suppressor of locomotor behavior defective | recessive | larval stage phenotype of park²⁵

(Vincent et al., 2012)

Scer\GAL4^Act5C.PU/Sod2^UAS.cMa is a non-suppressor of neurophysiology defective | larval stage phenotype of park^Z3678/park²⁵

(Vincent et al., 2012)

Sod2^UAS.cMa/Scer\GAL4^da.G32 is a non-suppressor of lethal phenotype of Scer\GAL4^da.G32, fh^dsRNA.IR.UAS

(Anderson et al., 2005)

Sod2^UAS.cMa/Scer\GAL4^Toll-6-D42 is a non-suppressor of short lived phenotype of Sod1^X-39

(Missirlis et al., 2003)

Sod2^UAS.cMa/Scer\GAL4^Mhc.PW is a non-suppressor of short lived phenotype of Sod1^X-39

(Missirlis et al., 2003)

Sod2^UAS.cMa/Scer\GAL4^da.G32 is a non-suppressor of short lived phenotype of Sod1^X-39

(Missirlis et al., 2003)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

Scer\GAL4^Ugt36A1.PK, Sod2^UAS.cMa has adult heart phenotype, non-enhanceable by Scer\GAL4^Hand.PA/Sod1^UAS.cWa

(Lim et al., 2014)

Enhancer of

Statement

Reference

Sod2^UAS.cMa/Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, Zzzz\CAG^{Q48.UAS.Tag:MYC,Tag:FLAG}

(Underwood et al., 2010)

NOT Enhancer of

Statement

Reference

Sod2^UAS.cMa/Scer\GAL4^Hand.PA is a non-enhancer of adult heart phenotype of Scer\GAL4^Ugt36A1.PK, Sod1^UAS.cWa

(Lim et al., 2014)

Suppressor of

Statement

Reference

Scer\GAL4^da.PU/Sod2^UAS.cMa is a suppressor of rhabdomere | progressive phenotype of YME1L^del

(Qi et al., 2016)

Sod2^UAS.cMa, Scer\GAL4^CCAP.PP is a suppressor of wing phenotype of Idh^{R195H.UAS.Tag:FLAG}, Scer\GAL4^CCAP.PP

(Reitman et al., 2015)

Sod2^UAS.cMa/Scer\GAL4^tin.CΔ4 is a suppressor of adult heart phenotype of Scer\GAL4^tin.CΔ4, park^HMS01651

(Bhandari et al., 2014)

Sod2^UAS.cMa/Scer\GAL4^tin.CΔ4 is a suppressor of cardial cell phenotype of Scer\GAL4^tin.CΔ4, park^HMS01651

(Bhandari et al., 2014)

Sod2^UAS.cMa/Scer\GAL4^tin.CΔ4 is a suppressor of mitochondrion phenotype of Scer\GAL4^tin.CΔ4, park^HMS01651

(Bhandari et al., 2014)

Sod2^UAS.cMa/Scer\GAL4^tin.CΔ4 is a suppressor of adult heart phenotype of Scer\GAL4^tin.CΔ4, park^HMS01800

(Bhandari et al., 2014)

Sod2^UAS.cMa/Scer\GAL4^tin.CΔ4 is a suppressor of cardial cell phenotype of Scer\GAL4^tin.CΔ4, park^HMS01800

(Bhandari et al., 2014)

Sod2^UAS.cMa/Scer\GAL4^tin.CΔ4 is a suppressor of mitochondrion phenotype of Scer\GAL4^tin.CΔ4, park^HMS01800

(Bhandari et al., 2014)

Scer\GAL4^Act5C.PU/Sod2^UAS.cMa is a suppressor of terminal bouton | third instar larval stage phenotype of park²⁵

(Vincent et al., 2012)

Sod2^UAS.cMa, Scer\GAL4^Antp-10 is a suppressor of lamellocyte | larval stage phenotype of ND-75^GD6309, Scer\GAL4^Antp-10

(Sinenko et al., 2011)

Sod2^UAS.cMa, Scer\GAL4^Hml.Δ is a suppressor | partially of embryonic/larval hemocyte | third instar larval stage phenotype of Hsap\RUNX1::Hsap\RUNX1T1^UAS.cSa, Scer\GAL4^Hml.Δ

(Sinenko et al., 2010)

Sod2^UAS.cMa, Scer\GAL4^elav.PU is a suppressor | partially of adult brain cell body rind phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

Sod2^UAS.cMa, Scer\GAL4^elav.PU is a suppressor | partially of neuropil | adult stage phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

Sod2^UAS.cMa, Scer\GAL4^elav.PU is a suppressor | partially of neuron | adult stage phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav.PU

(Dias-Santagata et al., 2007)

NOT Suppressor of

Statement

Reference

Sod2^UAS.cMa/Scer\GAL4^ninaE.PT is a non-suppressor of eye photoreceptor cell | somatic clone | adult stage phenotype of fh¹

(Chen et al., 2016)

Sod2^UAS.cMa/Scer\GAL4^Mef2.PR is a non-suppressor of mitochondrion | adult stage phenotype of Scer\GAL4^Mef2.PR, clu^GD13926

(Wang et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of bmm^Scer\UAS.cGa under the control of Scer\GAL4^ninaE.PT fails to rescue the neurodegeneration and electrophysiology defect seen in fh¹ mutant photoreceptor clones.

(Chen et al., 2016)

Expression of Sod2^Scer\UAS.cMa under the control of Scer\GAL4^da.PU suppresses the age-dependent loss of rhabdomeres and partially suppresses the age-dependent locomotor defect seen in YME1L^del homozygotes.

Expression of Sod2^Scer\UAS.cMa under the control of Scer\GAL4^da.PU extends the lifespan of YME1L^del homozygotes.

(Qi et al., 2016)

The larval locomotor deficit, very low adult eclosion rate as well as the mitochondrial morphology defects in adult indirect flight muscles (enlarged clustered mitochondria) characteristic for animals expressing clu^GD13926 under the control of Scer\GAL4^Mef2.PR cannot be suppressed by co-expression of Sod2^Scer\UAS.cMa.

(Wang et al., 2016)

Expression of Sod2^Scer\UAS.cMa suppresses the heart tube hypocontraction and increase in mitochondrial reactive oxygen species (ROS) seen when park^HMS01651 is expressed under the control of Scer\GAL4^tin.CΔ4.

Expression of Sod2^Scer\UAS.cMa suppresses the heart tube hypocontraction and increase in mitochondrial reactive oxygen species (ROS) seen when park^HMS01800 is expressed under the control of Scer\GAL4^tin.CΔ4.

(Bhandari et al., 2014)

Co-expression of Sod^Scer\UAS.cWa and Sod2^Scer\UAS.cMa in cardiomyocytes and nonmyocytic pericardial cells, under the control of Scer\GAL4^Hand.PA, which results in a significant increase in the level of physiological reactive oxygen species, has no significant effects on any major aspects of heart function, including heart rhythm or heart tube dimensions.

(Lim et al., 2014)

Expression of Sod2^Scer\UAS.cMa under the control of Scer\GAL4^Act5C.PU suppresses the synaptic overgrowth, but not the locomotion defects of park²⁵/park²⁵ larvae.

Expression of Sod2^Scer\UAS.cMa under the control of Scer\GAL4^Act5C.PU does not rescue the muscle resting membrane potential of park²⁵/park^Z3678 larvae.

(Vincent et al., 2012)

Expression of Sod2^Scer\UAS.cMa suppresses the increase in circulating lamellocytes seen when ND75^GD6309 is expressed under the control of Scer\GAL4^Antp-10.

(Sinenko et al., 2011)

Expression of Sod2^Scer\UAS.cMa under the control of Scer\GAL4^Mef2.PR partially rescues the reduced viability seen in p38b^Δ25 Mpk2¹ double mutants.

Expression of Sod2^Scer\UAS.cMa under the control of Scer\GAL4^Mef2.PR significantly rescues the abbreviated lifespan seen in p38b^Δ45 mutants.

(Vrailas-Mortimer et al., 2011)

Co-expression of Sod2^Scer\UAS.cMa extends the lifespan of flies expressing tws^Scer\UAS.cBa under the control of Scer\GAL4^elav.PU at 29[o]C.

(Wang et al., 2011)

Xenogenetic Interactions

Statement

Reference

Expression of Sod2^Scer\UAS.cMa strongly suppresses the hemocyte overproliferation seen in third instar larvae when Hsap\RUNX1::Hsap\RUNX1T1^Scer\UAS.cSa is expressed under the control of Scer\GAL4^Hml.Δ.

(Sinenko et al., 2010)

Overexpression of Sod2^Scer\UAS.cMa suppresses the decreased survival phenotype of flies expressing Hsap\APP^{Arctic.Scer\UAS.T:nec} under the control of Scer\GAL4^elav-C155.

Overexpression of Sod2^Scer\UAS.cMa suppresses the decline in locomotor function of flies expressing Hsap\APP^{Arctic.Scer\UAS.T:nec} under the control of Scer\GAL4^elav-C155.

(Rival et al., 2009)

Co-expression of Sod2^Scer\UAS.cMa partially suppresses the neuron apoptosis in the cortex and neuropil of adult brains expressing Hsap\MAPT^{R406W.Scer\UAS} under the control of Scer\GAL4^elav.PU.

(Dias-Santagata et al., 2007)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

24494

w¹; P{UAS-Sod2.M}UM83

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Sod2^Scer\UAS.cMa

Sod2^UAS.cMa

Name Synonyms

Saccharomyces cerevisiae UAS construct of Missirlis

(Missirlis et al., 2003)

Secondary FlyBase IDs

References (35)

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