Socs36EScer\UAS.P\T.cCa suppresses the tumor phenotypes of third instar larval wing discs observed either upon the expression of scribHMS01490 under the control of Scer\GAL4Bx-MS1096 or in dlg12/dlg1A40.2 transheterozygous (where Scer\GAL4en-e16E-driven expression leads to a significantly decreased cell number in the discs' posterior compartment).
Stat92EF/Stat92Ej6C8 males expressing Socs36EScer\UAS.P\T.cCa under the control of Scer\GAL4C587 show complete loss of somatic cyst progenitor cells, somatic cyst cells, germline stem cells, spermatogonia and spermatocytes after 2 days at 29[o]C.
The rough eye and extra R7 photoreceptor cell phenotypes caused by expression of Egfr::toract.Scer\UAS under the control of Scer\GAL4hs.2sev are not suppressed by co-expression of Socs36EScer\UAS.P\T.cCa.
bamhs.PO testes recovering after heat shock that also express Socs36EScer\UAS.P\T.cCa via Scer\GAL4Act5C.PP show a marked decrease in their ability to regain new germ line stem cells compared to recovering testes not expressing Socs36EScer\UAS.P\T.cCa.
Expression of Socs36EScer\UAS.P\T.cCa, under the control of Scer\GAL4en-e16E, in a Stat92E06346/+ background results in an exacerbation of the outstretched wing phenotype seen in Socs36EScer\UAS.P\T.cCa expressing flies. The outgrowth appears to be made of wing material. The missing anterior crossvein phenotype is not affected. However, 60% of these flies show ectopic venation in the wing. Likewise, expression of Socs36EAct5C.T:Ivir\HA1 under the control of Scer\GAL4en-e16E in a hop2/+ background induces ectopic vein formation in 17-26% of wings and the size and penetrance of the humeral outgrowth phenotype is increased. Coexpression of Socs36EScer\UAS.P\T.cCa and hopScer\UAS.cHa, under the control of Scer\GAL4en-e16E, partially suppresses the lethality of hopScer\UAS.cHa-expressing flies. This coexpression results in the full restoration of the anterior crossvein, which is lost in Socs36EScer\UAS.P\T.cCa-expressing flies. Expression of Socs36EScer\UAS.P\T.cCa under the control of Scer\GAL4en-e16E in a Egfrtop-EC20/+ background results in ectopic wing vein material in 86% of flies and occasional thinning of a section of the L4 longitudinal wing vein. The anterior crossvein loss phenotype of Socs36EScer\UAS.P\T.cCa-expressing flies is not affected. Expression of Socs36EScer\UAS.P\T.cCa under the control of Scer\GAL4en-e16E in a CblF165/+ background results in a partial rescue of the Socs36EScer\UAS.P\T.cCa anterior crossvein phenotype, with a reduction in penetrance from 95 to 48%. The penetrance of the outstretched wing phenotype of Scer\GAL4ap-md544>Socs36EScer\UAS.P\T.cCa flies is reduced from 82 to 54% when flies have a CblF165/+ background.
The increased number of apoptotic cells in the brain of adult flies expressing Hsap\MAPTScer\UAS.cWa under the control of Scer\GAL4repo.PU (using tub-Gal80[ts] to minimize the transgene expression during development) is increased further by co-expression of Socs36EScer\UAS.P\T.cCa.