FlyBase Allele Report: Dmel\Socs36E[UASp.cCa]

General Information

Symbol

Dmel\Socs36E^UASp.cCa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Callus

FlyBase ID

FBal0155806

Feature type

allele

Associated gene

Dmel\Socs36E

Associated Insertion(s)

Carried in Construct

P{UASp-Socs36E.C}

Also Known As

UAS-SOCS36E, UAS-SOCS

Key Links

Transgenic product class

wild_type

(Callus and Mathey-Prevot, 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Callus and Mathey-Prevot, 2002)

Mutagen

in vitro construct

(Bach et al., 2003)

Progenitor genotype

Carried in construct

P{UASp-Socs36E.C}

Cytology

Description

UASp regulatory sequences drive expression of Socs36E.

(Callus and Mathey-Prevot, 2002)

Allele components

Component

Use(s)

Regulatory region(s)

UASp

binary expression system - regulatory region

Encoded product / tool

Socs36E

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Colodner and Feany, 2010)

ameliorates cancer

modeled by scrib^HMS01490

(Bunker et al., 2015)

modeled by dlg1², dlg1^A40.2

(Bunker et al., 2015)

modeled by Sce¹

(Classen et al., 2009)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response, with Scer\GAL4^Act.PU

(Merkling et al., 2015)

abnormal memory | adult stage | RU486 conditional, with Scer\GAL4^{Mef2.247.Switch}

(Copf et al., 2011)

abnormal size | third instar larval stage, with Scer\GAL4^ap-md544

(Herranz et al., 2012)

decreased occurrence of cell division | embryonic stage | male, with Scer\GAL4^{VP16.nanos.UTR}

(Wawersik et al., 2005)

lethal - all die before end of P-stage | partially, with Scer\GAL4^en-e16E

(Callus and Mathey-Prevot, 2002)

short lived, with Scer\GAL4^Act5C.PI

(Callus and Mathey-Prevot, 2002)

short lived | conditional, with Scer\GAL4^Act.PU

(Merkling et al., 2015)

short lived | parental effect

(Callus and Mathey-Prevot, 2002)

some die during pharate adult stage | partially, with Scer\GAL4^en-e16E

(Callus and Mathey-Prevot, 2002)

visible, with Scer\GAL4^ap-md544

(Callus and Mathey-Prevot, 2002)

visible, with Scer\GAL4^en-e16E

(Callus and Mathey-Prevot, 2002)

visible, with Scer\GAL4^hs.2sev

(Almudi et al., 2009)

Phenotype Manifest In

anterior crossvein, with Scer\GAL4^en-e16E

(Callus and Mathey-Prevot, 2002)

border follicle cell, with Scer\GAL4^c306

(Monahan and Starz-Gaiano, 2013, Silver et al., 2005)

border follicle cell, with Scer\GAL4^slbo.2.6

(Silver et al., 2005)

germline cell | embryonic stage | male, with Scer\GAL4^{VP16.nanos.UTR}

(Wawersik et al., 2005)

haltere, with Scer\GAL4^en-e16E

(Callus and Mathey-Prevot, 2002)

male germline stem cell, with Scer\GAL4^{VP16.nanos.UTR}

(Sheng et al., 2009)

photoreceptor cell R7, with Scer\GAL4^hs.2sev

(Almudi et al., 2009)

pigment cell, with Scer\GAL4^en-e16E

(Callus and Mathey-Prevot, 2002)

postpronotum, with Scer\GAL4^en-e16E

(Callus and Mathey-Prevot, 2002)

wing, with Scer\GAL4^Act5C.PI

(Callus and Mathey-Prevot, 2002)

wing, with Scer\GAL4^ap-md544

(Callus and Mathey-Prevot, 2002)

wing disc dorsal compartment | third instar larval stage, with Scer\GAL4^ap-md544

(Herranz et al., 2012)

wing vein, with Scer\GAL4^Act5C.PI

(Callus and Mathey-Prevot, 2002)

Detailed Description

Statement

Reference

The expression of Socs36E^{Scer\UAS.P\T.cCa} under the control of Scer\GAL4^en-e16E does not result in significant changes in the cell number of the posterior compartment of third instar larval wing discs, nor in the viability of the discs, as compared to controls.

(Bunker et al., 2015)

Expression of Socs36E^{Scer\UAS.P\T.cCa} using Scer\GAL4^Act.PU increases mortality rates after infection with Drosophila C virus (DCV) compared with wild-type.

(Merkling et al., 2015)

Border cell cluster formation and migration is defective in females expressing Socs36E^{Scer\UAS.P\T.cCa} under the control of Scer\GAL4^c306, with cells failing to reach the oocyte in 53% of stage 10 egg chambers. The phenotype ranges in severity from cases in which a small number of anterior follicle cells are clustered around the polar cells but fail to migrate, to the invasive cells being splayed out along the migratory path instead of organised into a cohesive cluster.

Expression of Socs36E^{Scer\UAS.P\T.cCa} under the control of either Scer\GAL4^upd or Scer\GAL4^{Socs16D-NP7149} does not cause border cell defects.

(Monahan and Starz-Gaiano, 2013)

Expressing Socs36E^UASp.cCa under the control of Scer\GAL4^ap-md544 results in a significantly smaller wing disc dorsal compartment in third instar larvae compared to wild-type controls.

(Herranz et al., 2012)

Expression of Socs36E^{Scer\UAS.P\T.cCa} under the control of Scer\GAL4^{Mef2.247.Switch} specifically during the adult stage (in the presence of RU486) causes a striking defect in long term memory, without affecting anesthesia-resistant memory or short term memory.

(Copf et al., 2011)

Adult flies expressing Socs36E^{Scer\UAS.P\T.cCa} under the control of Scer\GAL4^repo.PU (using tub-Gal80[ts] to minimize the transgene expression during development) do not show any increase in the number of apoptotic cells in the adult brain compared to controls.

(Colodner and Feany, 2010)

Expression of Socs36E^{Scer\UAS.P\T.cCa} under the control of Scer\GAL4^hs.2sev results in a lack of photoreceptor cell R7 in 7% of ommatidia.

(Almudi et al., 2009)

Scer\GAL4^{nos.UTR.T:Hsim\VP16}-mediated expression of Socs36E^{Scer\UAS.P\T.cCa} causes germline stem cell loss.

Inducible Scer\GAL4^Act5C.PP-mediated expression of Socs36E^{Scer\UAS.P\T.cCa} (via heat shock and hs-flp of Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C}) does not cause a change in cell morphology or a significant loss of germline stem cells.

(Sheng et al., 2009)

Expression of Socs36E^{Scer\UAS.P\T.cCa}, under the control of either Scer\GAL4^slbo.2.6 or Scer\GAL4^c306, inhibits border cell migration and recruitment. Such egg chambers have an average of 3.3 border cells.

(Silver et al., 2005)

The proliferation of germ cells in male embryos expressing Socs36E^{Scer\UAS.P\T.cCa} under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} is reduced compared to control male embryos.

(Wawersik et al., 2005)

Hemocytes in Socs36E^Scer\UAS.cCa; Scer\GAL4^srp.Hemo late embryos do not exhibit abnormal aggregation.

(Bruckner et al., 2004)

Expression of Socs36E^{Scer\UAS.P\T.cCa} under the control of Scer\GAL4^ey.PH or Scer\GAL4^dpp.blk1 does not result in flies with enlarged eyes.

(Bach et al., 2003)

Expression of Socs36E^{Scer\UAS.P\T.cCa}, driven by Scer\GAL4^Act5C.PI, results in occasional wing vein defects and a significantly shorter lifespan. 94% of flies that express Socs36E^{Scer\UAS.P\T.cCa} under the control of Scer\GAL4^ap-md544 show an outstretched wing phenotype. 99% of flies that express one copy of Socs36E^{Scer\UAS.P\T.cCa} under the control of Scer\GAL4^en-e16E exhibit a loss of the anterior cross vein. Occasional wing deltas are also observed. Almost 40% of these flies show humeral outgrowths; this phenotype has a higher penetrance when flies are raised at 29^oC. 10-20% of flies show a partial or total loss of the halteres; this phenotype is also present at higher levels at 29^oC. Finally, these flies also display a strong gradient in eye pigmentation. Flies that express two copies of the Socs36E^{Scer\UAS.P\T.cCa} transgene, under the control of two copies of Scer\GAL4^en-e16E, often die as pharate adults. Those that survive to eclose show the phenotypes described above at a higher penetrance.

(Callus and Mathey-Prevot, 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^en-e16E, Socs36E^UASp.cCa has visible phenotype, enhanceable by Stat92E[+]/Stat92E⁰⁶³⁴⁶

(Callus and Mathey-Prevot, 2002)

Scer\GAL4^en-e16E, Socs36E^UASp.cCa has visible phenotype, enhanceable by hop²/hop[+]

(Callus and Mathey-Prevot, 2002)

Suppressed by

Statement

Reference

Scer\GAL4^ap-md544, Socs36E^UASp.cCa has visible phenotype, suppressible by Cbl^F165/Cbl[+]

(Callus and Mathey-Prevot, 2002)

Enhancer of

Statement

Reference

Scer\GAL80^ts.αTub84B, Socs36E^UASp.cCa, Scer\GAL4^repo.PU is an enhancer of increased cell death | adult stage phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^repo.PU, Scer\GAL80^ts.αTub84B

(Colodner and Feany, 2010)

Socs36E^UASp.cCa/Scer\GAL4^ey.PH is an enhancer of visible phenotype of upd1^unspecified/Df(1)os1A2

(Bach et al., 2003)

NOT Enhancer of

Statement

Reference

Scer\GAL4^Act.PU/Socs36E^UASp.cCa is a non-enhancer of abnormal immune response phenotype of G9a^DD2

(Merkling et al., 2015)

Scer\GAL4^Act.PU/Socs36E^UASp.cCa is a non-enhancer of short lived | conditional phenotype of G9a^DD2

(Merkling et al., 2015)

Suppressor of

Statement

Reference

Socs36E^UASp.cCa/Scer\GAL4^Bx-MS1096 is a suppressor of neoplasia | third instar larval stage phenotype of Scer\GAL4^Bx-MS1096, scrib^HMS01490

(Bunker et al., 2015)

Scer\GAL4^en-e16E/Socs36E^UASp.cCa is a suppressor of neoplasia | third instar larval stage phenotype of dlg1²

(Bunker et al., 2015)

Socs36E^UASp.cCa/Scer\GAL4^ey.PU is a suppressor of lethal | somatic clone phenotype of Snap29^B6-21

(Morelli et al., 2014)

Socs36E^UASp.cCa/Scer\GAL4^hs.2sev is a suppressor of visible phenotype of Scer\GAL4^hs.2sev, sev^S11.Tag:MYC

(Almudi et al., 2009)

Scer\GAL4^Act.PU/Socs36E^UASp.cCa is a suppressor of neoplasia | somatic clone phenotype of Sce¹

(Classen et al., 2009)

Scer\GAL4^en-e16E/Socs36E^UASp.cCa is a suppressor | partially of lethal phenotype of Scer\GAL4^en-e16E, hop^UAS.cHa

(Callus and Mathey-Prevot, 2002)

NOT Suppressor of

Statement

Reference

Scer\GAL4^Act.PU/Socs36E^UASp.cCa is a non-suppressor of abnormal immune response phenotype of G9a^DD2

(Merkling et al., 2015)

Scer\GAL4^Act.PU/Socs36E^UASp.cCa is a non-suppressor of short lived | conditional phenotype of G9a^DD2

(Merkling et al., 2015)

Socs36E^UASp.cCa/Scer\GAL4^hs.2sev is a non-suppressor of visible phenotype of N^nucl.sev

(Almudi et al., 2009)

Socs36E^UASp.cCa, Scer\GAL4^hs.2sev is a non-suppressor of visible phenotype of Egfr::tor^act.UAS, Scer\GAL4^hs.2sev

(Almudi et al., 2009)

Socs36E^UASp.cCa/Scer\GAL4^hs.2sev is a non-suppressor of visible phenotype of N^act.sev

(Almudi et al., 2009)

Other

Statement

Reference

Scer\GAL4^ey.PU, Snap29^B6-21, Socs36E^UASp.cCa has visible | somatic clone phenotype

(Morelli et al., 2014)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^en-e16E, Socs36E^UASp.cCa has wing phenotype, enhanceable by Stat92E[+]/Stat92E⁰⁶³⁴⁶

(Callus and Mathey-Prevot, 2002)

Scer\GAL4^en-e16E, Socs36E^UASp.cCa has wing phenotype, enhanceable by hop²/hop[+]

(Callus and Mathey-Prevot, 2002)

NOT Enhanced by

Statement

Reference

Scer\GAL4^en-e16E, Socs36E^UASp.cCa has anterior crossvein phenotype, non-enhanceable by Stat92E[+]/Stat92E⁰⁶³⁴⁶

(Callus and Mathey-Prevot, 2002)

Scer\GAL4^en-e16E, Socs36E^UASp.cCa has anterior crossvein phenotype, non-enhanceable by Egfr[+]/Egfr^top-EC20

(Callus and Mathey-Prevot, 2002)

Suppressed by

Statement

Reference

Scer\GAL4^en-e16E, Socs36E^UASp.cCa has anterior crossvein phenotype, suppressible by hop^UAS.cHa

(Callus and Mathey-Prevot, 2002)

Scer\GAL4^en-e16E, Socs36E^UASp.cCa has anterior crossvein phenotype, suppressible | partially by Cbl^F165/Cbl[+]

(Callus and Mathey-Prevot, 2002)

Scer\GAL4^en-e16E, Socs36E^UASp.cCa has wing phenotype, suppressible | partially by Cbl^F165/Cbl[+]

(Callus and Mathey-Prevot, 2002)

Enhancer of

Statement

Reference

Scer\GAL80^ts.αTub84B, Socs36E^UASp.cCa, Scer\GAL4^repo.PU is an enhancer of adult brain phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^repo.PU, Scer\GAL80^ts.αTub84B

(Colodner and Feany, 2010)

Scer\GAL4^C587/Socs36E^UASp.cCa is an enhancer of male germline stem cell | heat sensitive phenotype of Stat92E^F/Stat92E^j6C8

(Singh et al., 2010)

Scer\GAL4^C587/Socs36E^UASp.cCa is an enhancer of cyst progenitor cell | male | heat sensitive phenotype of Stat92E^F/Stat92E^j6C8

(Singh et al., 2010)

Scer\GAL4^C587/Socs36E^UASp.cCa is an enhancer of cyst cell of testis | heat sensitive phenotype of Stat92E^F/Stat92E^j6C8

(Singh et al., 2010)

Socs36E^UASp.cCa/Scer\GAL4^Act5C.PP is an enhancer of male germline stem cell | heat sensitive phenotype of bam^hs.PO

(Sheng et al., 2009)

Socs36E^UASp.cCa/Scer\GAL4^ey.PH is an enhancer of eye phenotype of upd1^unspecified/Df(1)os1A2

(Bach et al., 2003)

Suppressor of

Statement

Reference

Socs36E^UASp.cCa/Scer\GAL4^Bx-MS1096 is a suppressor of wing disc | third instar larval stage phenotype of Scer\GAL4^Bx-MS1096, scrib^HMS01490

(Bunker et al., 2015)

Scer\GAL4^en-e16E/Socs36E^UASp.cCa is a suppressor of wing disc | third instar larval stage phenotype of dlg1²

(Bunker et al., 2015)

Socs36E^UASp.cCa/Scer\GAL4^hs.2sev is a suppressor of eye phenotype of sev^S11.Tag:MYC

(Almudi et al., 2010)

Socs36E^UASp.cCa/Scer\GAL4^hs.2sev is a suppressor of eye phenotype of Scer\GAL4^hs.2sev, sev^S11.Tag:MYC

(Almudi et al., 2009)

Socs36E^UASp.cCa/Scer\GAL4^hs.2sev is a suppressor of photoreceptor cell R7 | increased number phenotype of Scer\GAL4^hs.2sev, sev^S11.Tag:MYC

(Almudi et al., 2009)

Scer\GAL4^Act.PU/Socs36E^UASp.cCa is a suppressor of eye disc | somatic clone phenotype of Sce¹

(Classen et al., 2009)

NOT Suppressor of

Statement

Reference

Socs36E^UASp.cCa, Scer\GAL4^hs.2sev is a non-suppressor of eye phenotype of Egfr::tor^act.UAS, Scer\GAL4^hs.2sev

(Almudi et al., 2009)

Socs36E^UASp.cCa, Scer\GAL4^hs.2sev is a non-suppressor of photoreceptor cell R7 | increased number phenotype of Egfr::tor^act.UAS, Scer\GAL4^hs.2sev

(Almudi et al., 2009)

Socs36E^UASp.cCa/Scer\GAL4^hs.2sev is a non-suppressor of eye phenotype of N^nucl.sev

(Almudi et al., 2009)

Socs36E^UASp.cCa/Scer\GAL4^hs.2sev is a non-suppressor of photoreceptor cell R7 | increased number phenotype of lz^sev.PF

(Almudi et al., 2009)

Socs36E^UASp.cCa/Scer\GAL4^hs.2sev is a non-suppressor of photoreceptor cell R7 | increased number phenotype of N^act.sev

(Almudi et al., 2009)

Socs36E^UASp.cCa/Scer\GAL4^hs.2sev is a non-suppressor of eye phenotype of N^act.sev

(Almudi et al., 2009)

Socs36E^UASp.cCa/Scer\GAL4^hs.2sev is a non-suppressor of photoreceptor cell R7 | increased number phenotype of N^nucl.sev

(Almudi et al., 2009)

Other

Statement

Reference

Scer\GAL4^ey.PU, Snap29^B6-21, Socs36E^UASp.cCa has eye | somatic clone phenotype

(Morelli et al., 2014)

Scer\GAL4^hs.2sev, Socs36E^UASp.cCa, drk^EP2477, sev^S11.Tag:MYC has eye phenotype

(Almudi et al., 2010)

Egfr^top-EC20, Scer\GAL4^en-e16E, Socs36E^UASp.cCa has wing vein | ectopic phenotype

(Callus and Mathey-Prevot, 2002)

Egfr^top-EC20, Scer\GAL4^en-e16E, Socs36E^UASp.cCa has wing vein L4 phenotype

(Callus and Mathey-Prevot, 2002)

Scer\GAL4^en-e16E, Socs36E^UASp.cCa, Stat92E[+]/Stat92E⁰⁶³⁴⁶ has wing vein | ectopic phenotype

(Callus and Mathey-Prevot, 2002)

Scer\GAL4^en-e16E, Socs36E^UASp.cCa, hop²/hop[+] has wing vein | ectopic phenotype

(Callus and Mathey-Prevot, 2002)

Egfr[+]/Egfr^top-EC20, Scer\GAL4^en-e16E, Socs36E^UASp.cCa has wing vein | ectopic phenotype

(Callus and Mathey-Prevot, 2002)

Egfr[+]/Egfr^top-EC20, Scer\GAL4^en-e16E, Socs36E^UASp.cCa has wing vein L4 phenotype

(Callus and Mathey-Prevot, 2002)

Scer\GAL4^en-e16E, Socs36E^UASp.cCa, Stat92E⁰⁶³⁴⁶ has wing vein | ectopic phenotype

(Callus and Mathey-Prevot, 2002)

Scer\GAL4^en-e16E, Socs36E^UASp.cCa, hop² has wing vein | ectopic phenotype

(Callus and Mathey-Prevot, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Socs36E^{Scer\UAS.P\T.cCa} suppresses the tumor phenotypes of third instar larval wing discs observed either upon the expression of scrib^HMS01490 under the control of Scer\GAL4^Bx-MS1096 or in dlg1²/dlg1^A40.2 transheterozygous (where Scer\GAL4^en-e16E-driven expression leads to a significantly decreased cell number in the discs' posterior compartment).

(Bunker et al., 2015)

Expression of Socs36E^{Scer\UAS.P\T.cCa} under the control of Scer\GAL4^ey.PU rescues the lethality of animals carrying Scer\GAL4^ey.PU mutant eye discs. The rescued adults have very reduced eyes.

(Morelli et al., 2014)

Expression of Socs36E^{Scer\UAS.P\T.cCa} under the control of Scer\GAL4^hs.2sev in a sev^{S11.T:Hsap\MYC} genetic background rescues the rough-eye phenotype.

Expression of drk^EP2477 and Socs36E^{Scer\UAS.P\T.cCa} under the control of Scer\GAL4^hs.2sev in a sev^{S11.T:Hsap\MYC} genetic background results in an intermediate rough-eye phenotype.

(Almudi et al., 2010)

Stat92E^F/Stat92E^j6C8 males expressing Socs36E^{Scer\UAS.P\T.cCa} under the control of Scer\GAL4^C587 show complete loss of somatic cyst progenitor cells, somatic cyst cells, germline stem cells, spermatogonia and spermatocytes after 2 days at 29[o]C.

(Singh et al., 2010)

Co-expression of Socs36E^{Scer\UAS.P\T.cCa} suppresses the rough eye and extra R7 photoreceptor cell phenotype caused by expression of sev^{S11.T:Hsap\MYC} under the control of Scer\GAL4^hs.2sev.

The rough eye and extra R7 photoreceptor cell phenotypes caused by expression of Egfr::tor^act.Scer\UAS under the control of Scer\GAL4^hs.2sev are not suppressed by co-expression of Socs36E^{Scer\UAS.P\T.cCa}.

The extra R7 photoreceptor cell phenotype caused by lz^sev.PF is not suppressed by expression of Socs36E^{Scer\UAS.P\T.cCa} under the control of Scer\GAL4^hs.2sev.

The rough eye and extra R7 photoreceptor cell phenotypes caused by N^nucl.sev are not suppressed by expression of Socs36E^{Scer\UAS.P\T.cCa} under the control of Scer\GAL4^hs.2sev.

The rough eye and extra R7 photoreceptor cell phenotypes caused by N^act.sev are not suppressed by expression of Socs36E^{Scer\UAS.P\T.cCa} under the control of Scer\GAL4^hs.2sev.

(Almudi et al., 2009)

Expression of Socs36E^{Scer\UAS.P\T.cCa} under the control of Scer\GAL4^Act.PU suppresses the overgrowth of Sce¹ mutant eye discs.

(Classen et al., 2009)

bam^hs.PO testes recovering after heat shock that also express Socs36E^{Scer\UAS.P\T.cCa} via Scer\GAL4^Act5C.PP show a marked decrease in their ability to regain new germ line stem cells compared to recovering testes not expressing Socs36E^{Scer\UAS.P\T.cCa}.

(Sheng et al., 2009)

The small eye phenotype of upd1^unspecified/Df(1)os1A2 flies is enhanced by expression of Socs36E^{Scer\UAS.P\T.cCa} under the control of Scer\GAL4^ey.PH.

(Bach et al., 2003)

Expression of Socs36E^{Scer\UAS.P\T.cCa}, under the control of Scer\GAL4^en-e16E, in a Stat92E⁰⁶³⁴⁶/+ background results in an exacerbation of the outstretched wing phenotype seen in Socs36E^{Scer\UAS.P\T.cCa} expressing flies. The outgrowth appears to be made of wing material. The missing anterior crossvein phenotype is not affected. However, 60% of these flies show ectopic venation in the wing. Likewise, expression of Socs36E^{Act5C.T:Ivir\HA1} under the control of Scer\GAL4^en-e16E in a hop²/+ background induces ectopic vein formation in 17-26% of wings and the size and penetrance of the humeral outgrowth phenotype is increased. Coexpression of Socs36E^{Scer\UAS.P\T.cCa} and hop^Scer\UAS.cHa, under the control of Scer\GAL4^en-e16E, partially suppresses the lethality of hop^Scer\UAS.cHa-expressing flies. This coexpression results in the full restoration of the anterior crossvein, which is lost in Socs36E^{Scer\UAS.P\T.cCa}-expressing flies. Expression of Socs36E^{Scer\UAS.P\T.cCa} under the control of Scer\GAL4^en-e16E in a Egfr^top-EC20/+ background results in ectopic wing vein material in 86% of flies and occasional thinning of a section of the L4 longitudinal wing vein. The anterior crossvein loss phenotype of Socs36E^{Scer\UAS.P\T.cCa}-expressing flies is not affected. Expression of Socs36E^{Scer\UAS.P\T.cCa} under the control of Scer\GAL4^en-e16E in a Cbl^F165/+ background results in a partial rescue of the Socs36E^{Scer\UAS.P\T.cCa} anterior crossvein phenotype, with a reduction in penetrance from 95 to 48%. The penetrance of the outstretched wing phenotype of Scer\GAL4^ap-md544>Socs36E^{Scer\UAS.P\T.cCa} flies is reduced from 82 to 54% when flies have a Cbl^F165/+ background.

(Callus and Mathey-Prevot, 2002)

Xenogenetic Interactions

Statement

Reference

The increased number of apoptotic cells in the brain of adult flies expressing Hsap\MAPT^Scer\UAS.cWa under the control of Scer\GAL4^repo.PU (using tub-Gal80[ts] to minimize the transgene expression during development) is increased further by co-expression of Socs36E^{Scer\UAS.P\T.cCa}.

(Colodner and Feany, 2010)

Complementation and Rescue Data

Rescues

Scer\GAL4^c306/Socs36E^UASp.cCa rescues Socs36E¹⁷⁸/Df(2L)Exel8038

(Monahan and Starz-Gaiano, 2013)

Scer\GAL4^C587/Socs36E^UASp.cCa rescues Socs36E^EY06665

(Singh et al., 2010)

Scer\GAL4^unspecified/Socs36E^UASp.cCa rescues Socs36E^PZ1647

(Issigonis et al., 2009)

Comments

Expression of Socs36E^{Scer\UAS.P\T.cCa} under the control of Scer\GAL4^C587 rescues the mutant cyst progenitor cell phenotype seen in the testes of Socs36E^EY06665 males.

(Singh et al., 2010)

Expression of Socs36E^{Scer\UAS.P\T.cCa} in a Socs36E^PZ1647 mutant background rescues the abnormal male germline stem cell number phenotype.

(Issigonis et al., 2009)

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Mutant

Wild-type

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Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Socs36E^{Scer\UAS.P\T.cCa}

Socs36E^Scer\UAS.cCa

Socs36E^UASp.cCa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Callus

(Bach et al., 2003)

Secondary FlyBase IDs

References (23)

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