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General Information
Symbol
Scer\GAL4Mef2.247.Switch
Species
S. cerevisiae
Name
FlyBase ID
FBal0155866
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
MB-GS-GAL4, MB-GeneSwitch, MB-Switch, MB247-Switch, MB-Sw, MB-GS, Mushroom body-Geneswitch, MB247-GeneSwitch
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

The Mef2 enhancer element from Scer\GAL4Mef2.247, fused to a minimal Hsp70Bb promoter, controls expression of the ligand-inducible GAL4::GS driver.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Expression Data
Reporter Expression
distribution deduced from reporter (Gal4 UAS)
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Information
Statement
Reference

Drives mifepristone-inducible expression in mushroom bodies.

Scer\GAL4Mef2.247.Switch drives mifepristone-inducible expression in the adult mushroom body.

 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Hyperpolarisation (using Hsap\KCNJ2UAS.cUa.EGFP) of Scer\GAL4Mef2.247.Switch neurons (induced by RU486 application for three days prior to the experiment) significantly impairs visual short term memory following training with pain stimulus in adult flies, compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Enhancer of
NOT Enhancer of
Statement
Reference
Suppressor of
NOT Suppressor of
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
Comments
Comments

The transactivation activity of the "GeneSwitch" protein expressed from this vector depends on the presence of RU486.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Scer\GAL4Mef2.247.Switch
Name Synonyms
Secondary FlyBase IDs
    References (35)