Allele Dmel\S^48-5

General Information
Symbol	Dmel\S^48-5	Species	D. melanogaster
Name		FlyBase ID	FBal0155935
Feature type	allele	Associated gene	Dmel\S

Allele class
Mutagen
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	cell polarity defective (Gaengel and Mlodzik, 2003) increased cell death \| pupal stage P7 (Montrasio et al., 2007)
Phenotype Manifest In
	eye (Montrasio et al., 2007) inter-ommatidial precursor cell \| pupal stage P7 (Montrasio et al., 2007) ommatidium (Gaengel and Mlodzik, 2003, Montrasio et al., 2007) ommatidium \| pupal stage P7 (Montrasio et al., 2007) photoreceptor cell (Gaengel and Mlodzik, 2003)
Detailed Description
	Statement Reference S[48-5] heterozygous mutants display a strong eye roughening phenotype and approximately 10% of ommatidia display orientation defects. Programmed cell death in the pupal eye disc (42 hours after pupal formation) is defective and a loss of interommatidial cells is observed. (Montrasio et al., 2007) S^48-5/+ animals show a mild loss of photoreceptors and ommatidial rotation abnormalities. (Gaengel and Mlodzik, 2003)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference S^48-5 has cell polarity defective phenotype, enhanceable by capt⁰⁶⁹⁵⁵ (Gaengel and Mlodzik, 2003) S^48-5 has cell polarity defective phenotype, enhanceable by chic⁰¹³²⁰ (Gaengel and Mlodzik, 2003) S^48-5 has cell polarity defective phenotype, enhanceable by cno² (Gaengel and Mlodzik, 2003) S^48-5 has cell polarity defective phenotype, enhanceable by cno³ (Gaengel and Mlodzik, 2003) S^48-5 has cell polarity defective phenotype, enhanceable by Egfr^t1 (Gaengel and Mlodzik, 2003) S^48-5 has cell polarity defective phenotype, enhanceable by pnut⁰²⁵⁰² (Gaengel and Mlodzik, 2003) S^48-5 has cell polarity defective phenotype, enhanceable by pnut^XP (Gaengel and Mlodzik, 2003) S^48-5 has cell polarity defective phenotype, enhanceable by Ras85D^e2F (Gaengel and Mlodzik, 2003) S^48-5 has cell polarity defective phenotype, enhanceable by shg² (Gaengel and Mlodzik, 2003) S^48-5 has cell polarity defective phenotype, enhanceable by spi¹ (Gaengel and Mlodzik, 2003) S^48-5 has cell polarity defective phenotype, enhanceable by spi²⁵⁹ (Gaengel and Mlodzik, 2003) S^48-5 has cell polarity defective phenotype, enhanceable by stan^E59 (Gaengel and Mlodzik, 2003) S^48-5 has cell polarity defective phenotype, enhanceable by zip¹ (Gaengel and Mlodzik, 2003) S^48-5 has cell polarity defective phenotype, enhanceable by zip⁰²⁹⁵⁷ (Gaengel and Mlodzik, 2003)
Phenotype Manifest In
Enhanced by
Statement Reference S^48-5 has ommatidium phenotype, enhanceable by capt⁰⁶⁹⁵⁵ (Gaengel and Mlodzik, 2003) S^48-5 has ommatidium phenotype, enhanceable by chic⁰¹³²⁰ (Gaengel and Mlodzik, 2003) S^48-5 has ommatidium phenotype, enhanceable by cno² (Gaengel and Mlodzik, 2003) S^48-5 has ommatidium phenotype, enhanceable by cno³ (Gaengel and Mlodzik, 2003) S^48-5 has ommatidium phenotype, enhanceable by Egfr^t1 (Gaengel and Mlodzik, 2003) S^48-5 has ommatidium phenotype, enhanceable by pnut⁰²⁵⁰² (Gaengel and Mlodzik, 2003) S^48-5 has ommatidium phenotype, enhanceable by pnut^XP (Gaengel and Mlodzik, 2003) S^48-5 has ommatidium phenotype, enhanceable by Ras85D^e2F (Gaengel and Mlodzik, 2003) S^48-5 has ommatidium phenotype, enhanceable by shg² (Gaengel and Mlodzik, 2003) S^48-5 has ommatidium phenotype, enhanceable by spi¹ (Gaengel and Mlodzik, 2003) S^48-5 has ommatidium phenotype, enhanceable by spi²⁵⁹ (Gaengel and Mlodzik, 2003) S^48-5 has ommatidium phenotype, enhanceable by stan^E59 (Gaengel and Mlodzik, 2003) S^48-5 has ommatidium phenotype, enhanceable by zip¹ (Gaengel and Mlodzik, 2003) S^48-5 has ommatidium phenotype, enhanceable by zip⁰²⁹⁵⁷ (Gaengel and Mlodzik, 2003)
Suppressor of
Statement Reference S[+]/S^48-5 is a suppressor \| partially of ommatidium phenotype of ec^spok (Montrasio et al., 2007)
Additional Comments
Genetic Interactions
Statement Reference The ommatidial rotation defects observed in ec[spok] hemizygous adult eyes are partially suppressed by S[48-5]/+. (Montrasio et al., 2007) S^48-5/spi²⁵⁹ mutants show 37.83%+-13.35 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/spi¹ mutants show 40.04%+-3.7 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/grk³ mutants show 3.14%+-2.58 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/vn^addC6 mutants show 10.02%+-3.27 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/argos^rlt mutants show 3.74%+-1.99 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/Egfr^t1 mutants show 41.52%+-7.24 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/Ras85D^e2F mutants show 58.05%+-4.57 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/cno² mutants show 40.56%+-7.99 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/cno³ mutants show 43.24%+-8.67 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/nmo^P1 mutants show 17.38%+-5.39 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/shg² mutants show 40.56%+-5.21 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/arm² mutants show 12/43%+-5.66 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/stan^E59 mutants show 45.59%+-7.32 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/wb⁰⁹⁴³⁷ mutants show 13.2%+-3.05 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/wb⁴⁴¹⁸ mutants show 7.17%+-0.60 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/mys^unspecified mutants show 4.44%+-2.59 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/mys¹ mutants show 7.64%+-3.82 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/ena⁰²⁰²⁹ mutants show 7.77%+-2.95 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/pnut^XP mutants show 24.58%+-5.90 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/pnut⁰²⁵⁰² mutants show 20.07%+-11.25 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/zip⁰²⁹⁵⁷ mutants show 34.60%+-4.71 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/zip¹ mutants show 19.34%+-7.06 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/Khc⁸ mutants show 10.38%+-5.72 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/Khc^k13314 mutants show 2.87%+-2.04 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/ck¹³ mutants show 5.41%+-2.22 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/capt⁰⁶⁹⁵⁵ mutants show 34.19%+-8.94 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/kst⁰¹³¹⁸ mutants show 5.62%+-1.13 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/sca^BP1 mutants show 9.75%+-3.06 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. S^48-5/chic⁰¹³²⁰ mutants show 21.90%+-5.89 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone. (Gaengel and Mlodzik, 2003)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	S^48-5 S^48.5 (Montrasio et al., 2007)
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Montrasio et al., 2007, Dev. Dyn. 236(10): 2936--2942 A new allele uncovers the role of echinus in the control of ommatidial rotation in the Drosophila eye. [FBrf0202297] Gaengel and Mlodzik, 2003, Development 130(22): 5413--5423 Egfr signaling regulates ommatidial rotation and cell motility in the Drosophila eye via MAPK/Pnt signaling and the Ras effector Canoe/AF6. [FBrf0167499]

Allele Dmel\S48-5

Allele Dmel\S^48-5