Allele Rat\CaMKIINα^{I.Scer\UAS.cHa}

General Information
Symbol	Rat\CaMKIINα^{I.Scer\UAS.cHa}	Species	R. unknown
Name		FlyBase ID	FBal0155989
Feature type	allele	Associated gene	Rat\CaMKIINα

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - deletion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - deletion (Haghighi et al., 2003) in vitro construct - regulatory fusion (Haghighi et al., 2003)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Expression of the inhibitory domain of Rat\CaMKIINα (MKRPPKLGQIGRSKRVVIEDDRIDDVLK) is under the control of Scer\UAS sequences. (Haghighi et al., 2003)
Carried in construct	P{UAS-CaMKIINα.I} (Haghighi et al., 2003)
Cytology
Phenotypic Data
Phenotypic Class
	neurophysiology defective, with Scer\GAL4^Mhc.PW (Haghighi et al., 2003)
Phenotype Manifest In

Detailed Description
	Statement Reference In neuromuscular junctions of Rat\CaMKIINα^{I.Scer\UAS.cHa}; Scer\GAL4^Mhc.PW larvae, quantal content is significantly greater than wild-type. When 2 copies of Rat\CaMKIINα^{I.Scer\UAS.cHa} are present quantal content is increased further and there is a significant increase in excitatory postsynaptic potential (EPSP) amplitude and in mini-EPSP frequency. Mini-EPSP amplitude and kinetics are unaffected as is membrane potential and input resistance of the muscles. (Data from electrophysiological recordings made from muscle 6 in segment A3 of wandering 3rd instar larvae). (Haghighi et al., 2003)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference Rat\CaMKIINα^{I.Scer\UAS.cHa}, Scer\GAL4^C142 has neurophysiology defective phenotype, suppressible \| partially by wit^HA4/wit^HA5 (Haghighi et al., 2003)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference wit^HA4/wit^HA5 suppresses the increase in the excitatory postsynaptic potential amplitude seen in the neuromuscular junctions of Rat\CaMKIINα^{I.Scer\UAS.cHa}; Scer\GAL4^C142 larvae. (Data from electrophysiological recordings made from muscle 6 in segment A3 of wandering 3rd instar larvae). (Haghighi et al., 2003)
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Rat\CaMKIINα^{I.Scer\UAS.cHa}
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Haghighi et al., 2003, Neuron 39(2): 255--267 Retrograde control of synaptic transmission by postsynaptic CaMKII at the Drosophila neuromuscular junction. [FBrf0160587]

Allele Rat\CaMKIINαI.Scer\UAS.cHa

Allele Rat\CaMKIINα^{I.Scer\UAS.cHa}