Allele Dmel\Itp-r83A^wc361

General Information
Symbol	Dmel\Itp-r83A^wc361	Species	D. melanogaster
Name		FlyBase ID	FBal0156339
Feature type	allele	Associated gene	Dmel\Itp-r83A
Also Known As	itpr^wc361

Map ( GBrowse )
Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Joshi et al., 2004, Deshpande et al., 2000)
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3R:1,364,323..1,364,323 evidence=experimental na_change=C1364323T pr_change=R2813\|Itp-r83A-PA,R2822\|Itp-r83A-PB reported_na_change=C?T reported_pr_change=R2814@ (Joshi et al., 2004, Deshpande et al., 2000)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: R2814@. Nucleotide substitution: C?T. (Joshi et al., 2004)
Cytology
Phenotypic Data
Phenotypic Class
	flight defective (with Itp-r83A^ka1091) (Banerjee et al., 2004) flight defective (with Itp-r83A^sa54) (Banerjee et al., 2004) flight defective (with Itp-r83A^wc703) (Banerjee et al., 2004) flightless (with Itp-r83A^ug3) (Banerjee et al., 2004) flightless \| partially (with Itp-r83A^wc703) (Banerjee et al., 2006) lethal \| partially (with Itp-r83A^sa54) (Joshi et al., 2004) lethal \| partially (with Itp-r83A^ug3) (Joshi et al., 2004) lethal \| partially \| cold sensitive (with Itp-r83A^ka901) (Joshi et al., 2004) lethal \| partially \| cold sensitive (with Itp-r83A^wc703) (Joshi et al., 2004) lethal \| recessive (Joshi et al., 2004) viable (with Itp-r83A^ug3) (Deshpande et al., 2000) viable (with Itp-r83A^wc703) (Banerjee et al., 2006)
Phenotype Manifest In

Detailed Description
	Statement Reference The spontaneous firing rate seen in dorsal-longitudinal muscles of Itp-r83A[wc361]/Itp-r83A[wc703] adults is normal. These adults can be divided into fliers and non-fliers (assayed using a cylinder drop test). About 30% are non-fliers - exhibiting only brief rhythmic flight patterns that are usually not sustained beyond 5 seconds in response to stimulation with an air puff. In contrast, the non-fliers exhibit sustained flight patterns (>30 seconds) in response to the same stimulus. (Banerjee et al., 2006) Itp-r83A^wc703/Itp-r83A^wc361, Itp-r83A^ka1091/Itp-r83A^wc361 and Itp-r83A^sa54/Itp-r83A^wc361 flies all show normal wing posture but do show a significant degree of flightlessness. (Banerjee et al., 2004) Itp-r83A^wc361/Itp-r83A^ug3 transheterozygotes are adaptation response defective. (Deshpande et al., 2000)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Gα49B[+]/Gαq^221c, Itp-r83A^wc703/Itp-r83A^wc361 has flightless \| partially phenotype, enhanceable by Plc21C^k31911/Plc21C[+] (Banerjee et al., 2006) Itp-r83A^wc703/Itp-r83A^wc361 has flightless \| partially phenotype, enhanceable by Gα49B[+]/Gαq^221c (Banerjee et al., 2006)
Suppressed by
Statement Reference Gα49B[+]/Gαq^221c, Itp-r83A^wc703/Itp-r83A^wc361, Plc21C^k31911/Plc21C[+] has flightless \| partially phenotype, suppressible by Ca-P60A[+]/Ca-P60A^Kum170 (Banerjee et al., 2006) Gα49B[+]/Gαq^221c, Itp-r83A^wc703/Itp-r83A^wc361, Plc21C^k31911/Plc21C[+] has neurophysiology defective phenotype, suppressible by Ca-P60A[+]/Ca-P60A^Kum170 (Banerjee et al., 2006) Gα49B[+]/Gαq^221c, Itp-r83A^wc703/Itp-r83A^wc361 has flightless \| partially phenotype, suppressible \| partially by Gαq^Scer\UAS.cRa/Scer\GAL4^Ddc.PL (Banerjee et al., 2006) Gα49B[+]/Gαq^221c, Itp-r83A^wc703/Itp-r83A^wc361 has flightless \| partially phenotype, suppressible by Ca-P60A[+]/Ca-P60A^Kum170 (Banerjee et al., 2006) Gα49B[+]/Gαq^221c, Itp-r83A^wc703/Itp-r83A^wc361 has neurophysiology defective phenotype, suppressible \| partially by Gαq^Scer\UAS.cRa/Scer\GAL4^Ddc.PL (Banerjee et al., 2006) Gα49B[+]/Gαq^221c, Itp-r83A^wc703/Itp-r83A^wc361 has neurophysiology defective phenotype, suppressible by Ca-P60A[+]/Ca-P60A^Kum170 (Banerjee et al., 2006)
Other
Statement Reference Gα49B[+]/Gαq^221c, Itp-r83A^wc703/Itp-r83A^wc361, Plc21C^k31911/Plc21C[+] has partially lethal - majority die phenotype (Banerjee et al., 2006) Gα49B[+]/Gαq^221c, Itp-r83A^wc703/Itp-r83A^wc361 has neurophysiology defective phenotype (Banerjee et al., 2006)
Phenotype Manifest In
Enhanced by
Statement Reference Gα49B[+]/Gαq^221c, Itp-r83A^wc703/Itp-r83A^wc361 has wing phenotype, enhanceable by Plc21C^k31911/Plc21C[+] (Banerjee et al., 2006)
Suppressed by
Statement Reference Gα49B[+]/Gαq^221c, Itp-r83A^wc703/Itp-r83A^wc361, Plc21C^k31911/Plc21C[+] has wing phenotype, suppressible by Ca-P60A[+]/Ca-P60A^Kum170 (Banerjee et al., 2006) Gα49B[+]/Gαq^221c, Itp-r83A^wc703/Itp-r83A^wc361 has wing phenotype, suppressible \| partially by Gαq^Scer\UAS.cRa/Scer\GAL4^Ddc.PL (Banerjee et al., 2006) Gα49B[+]/Gαq^221c, Itp-r83A^wc703/Itp-r83A^wc361 has wing phenotype, suppressible by Ca-P60A[+]/Ca-P60A^Kum170 (Banerjee et al., 2006)
Other
Statement Reference Gα49B[+]/Gαq^221c, Itp-r83A^wc703/Itp-r83A^wc361 has wing phenotype (Banerjee et al., 2006)
Additional Comments
Genetic Interactions
Statement Reference The viability of Itp-r83A[wc703]/Itp-r83A[wc361] animals is unaffected by sl[1]/sl[1] or sl[2]/sl[2]. It is also unaffected by Gα49B[221c]/+, but the resulting adults have abnormal wing posture, an enhanced incidence of flight defects and mild endogenous hyperactivity of spontaneous firing recorded from the dorsal longitudinal muscles. Wing posture and flight defect phenotypes are enhanced and viability is reduced if Plc21C[k31911]/+ is also present, but partially suppressed by Gα49B[Scer\UAS.cRa]; Scer\GAL4[Ddc.PL] and completely or largely suppressed by Ca-P60A[Kum170]/+, even when Plc21C[k31911]/+ is also present. (Banerjee et al., 2006)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Complements	Itp-r83A^90B.0 (Joshi et al., 2004) Itp-r83A⁰⁵⁶¹⁶ (Deshpande et al., 2000) Itp-r83A^B4 (Joshi et al., 2004) Itp-r83A^ug3 (Deshpande et al., 2000) Itp-r83A^wc703 (Deshpande et al., 2000) Itp-r83A^XR12 (Joshi et al., 2004)
Partially complements	Itp-r83A⁰⁵⁶¹⁶ (Joshi et al., 2004)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Allelic series: Itp-r83A^sv35 >= Itp-r83A^ka901 > Itp-r83A^sa54 >= Itp-r83A^ka1091 > Itp-r83A^wc703 > Itp-r83A^ug3 > Itp-r83A^wc361. (Joshi et al., 2004)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	Itp-r83A^wc361 itpr^wc361 (Banerjee et al., 2004, Banerjee et al., 2006) wc361 (Joshi et al., 2004, )
Name Synonym
Secondary FlyBase IDs

References ( 4 )
Research paper	Banerjee et al., 2006, J. Neurosci. 26(32): 8278--8288 Compensation of inositol 1,4,5-trisphosphate receptor function by altering sarco-endoplasmic reticulum calcium ATPase activity in the Drosophila flight circuit. [FBrf0194925] Banerjee et al., 2004, J. Neurosci. 24(36): 7869--7878 Loss of flight and associated neuronal rhythmicity in inositol 1,4,5-trisphosphate receptor mutants of Drosophila. [FBrf0180425] Joshi et al., 2004, Genetics 166(1): 225--236 Genetic dissection of itpr gene function reveals a vital requirement in aminergic cells of Drosophila larvae. [FBrf0174703] Deshpande et al., 2000, J. Neurobiol. 43(3): 282--288 The inositol 1,4,5-trisphosphate receptor is required for maintenance of olfactory adaptation in Drosophila antennae. [FBrf0128448]

Allele Dmel\Itp-r83Awc361

Allele Dmel\Itp-r83A^wc361