FlyBase Allele Report: Dmel\InR[UAS.Exel]

General Information

Symbol

Dmel\InR^UAS.Exel

Species

D. melanogaster

Name

FlyBase ID

FBal0156356

Feature type

allele

Associated gene

Dmel\InR

Associated Insertion(s)

Carried in Construct

P{UAS-InR.Exel}

Also Known As

UAS-InR, UAS-InR.Exel, UAS-InR^WT, UAS-InRwt

Key Links

Transgenic product class

wild_type

(Parks, 2004.5.12)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Parks, 2004.5.12)

Mutagen

in vitro construct

(Parks, 2004.5.12)

Progenitor genotype

Carried in construct

P{UAS-InR.Exel}

Cytology

Description

UAS regulatory sequences drive expression of InR coding sequences corresponding to accession AAC47458.

(Parks, 2004.5.12)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

InR

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cancer

CEA

(Khaket et al., 2024)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Tandon and Sarkar, 2021, Raj and Sarkar, 2019)

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Raj and Sarkar, 2019)

modeled by Hsap\HTT^{Q138.UAS.mRFP1}

(Tandon and Sarkar, 2021, Raj and Sarkar, 2019)

ameliorates syndrome

modeled by NSD^EY01950

(Quintero-Rivera et al., 2021)

exacerbates cancer

modeled by scrib¹

(Sanaki et al., 2020)

model of cancer

is ameliorated by SARS-CoV-2\nsp1^UAS.cZa

(Khaket et al., 2024)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage | somatic clone, with Scer\GAL4^{DIP-γ-MI03222-GAL4}

(Luo et al., 2020)

abnormal neuroanatomy | larval stage, with Scer\GAL4^repo

(Dong et al., 2021)

abnormal size, with Scer\GAL4^sd-SG29.1

(Tsuda et al., 2010)

abnormal size | adult stage, with Scer\GAL4^en-e16E

(Liu et al., 2017)

decreased cell number | larval stage, with Scer\GAL4^repo

(Dong et al., 2021)

increased body size | pupal stage, with Scer\GAL4^Cg.PA

(Li et al., 2022)

increased cell size | third instar larval stage, with Scer\GAL4^AB1

(Sharma et al., 2019)

increased occurrence of cell division | adult stage, with Scer\GAL4^NP5130

(Biteau et al., 2010)

short lived, with Scer\GAL4^NP5130, Scer\GAL80^ts.αTub84B

(Biteau et al., 2010)

visible, with Scer\GAL4^ap-md544

(Lee et al., 2010)

Phenotype Manifest In

adult gut, with Scer\GAL4^NP5130, Scer\GAL80^ts.αTub84B

(Biteau et al., 2010)

dendrite | adult stage | somatic clone, with Scer\GAL4^{DIP-γ-MI03222-GAL4}

(Luo et al., 2020)

distal medullary amacrine neuron Dm8 | adult stage | somatic clone, with Scer\GAL4^{DIP-γ-MI03222-GAL4}

(Luo et al., 2020)

ellipsoid body, with Scer\GAL4^ccb-796

(Martin-Pena et al., 2006)

eye, with Scer\GAL4^GMR.PF

(Lv et al., 2012)

fat cell | third instar larval stage, with Scer\GAL4^AB1

(Sharma et al., 2019)

neuroblast | decreased number | larval stage, with Scer\GAL4^repo

(Dong et al., 2021)

neuron | increased number, with Scer\GAL4^ccb-796

(Martin-Pena et al., 2006)

ommatidium, with Scer\GAL4^GMR.PF

(Lv et al., 2012)

synapse | increased number, with Scer\GAL4^Toll-6-D42

(Martin-Pena et al., 2006)

wing, with Scer\GAL4^sd-SG29.1

(Tsuda et al., 2010)

wing blade, with Scer\GAL4^ap-md544

(Lee et al., 2010)

wing posterior compartment, with Scer\GAL4^en-e16E

(Liu et al., 2017)

Detailed Description

Statement

Reference

The expression of InR^UAS.Exel under the control of Scer\GAL4^repo leads to a decrease in the number of neuroblasts.

(Dong et al., 2021)

Third instar larvae expressing InR^UAS.Exel under the control of Scer\GAL4^AB1 show significantly bigger salivary gland cells, as compared to controls.

(Sharma et al., 2019)

The expression of InR^{Scer\UAS.Exel} under the control of Scer\GAL4^en-e16E leads to a significant increase in the wing posterior compartment area, as compared to controls.

(Liu et al., 2017)

Overexpression of InR^{Scer\UAS.Exel} in the developing eye, under the control of Scer\GAL4^GMR.PF, causes large, disorganised eyes.

(Lv et al., 2012)

Transient overexpression of InR^{Scer\UAS.Exel} in adults under the control of Scer\GAL4^esg-NP5130 and Scer\GAL80^ts.αTub84B induces increased proliferation of intestinal cells compared with controls.

Transient overexpression of InR^{Scer\UAS.Exel} in adults under the control of Scer\GAL4^esg-NP5130 and Scer\GAL80^ts.αTub84B results in significant lifespan shortening compared with wild-type.

(Biteau et al., 2010)

Expression of InR^{Scer\UAS.Exel} driven by Scer\GAL4^ap-md544 in dorsal cells of the wing causes an overgrowth phenotype in which the wing bends downward.

(Lee et al., 2010)

Overexpression of InR^{Scer\UAS.Exel} in the wing imaginal disc using Scer\GAL4^sd-SG29.1 results in increased wing size in adult flies compared with wild-type.

(Tsuda et al., 2010)

InR^{Scer\UAS.Exel} overexpression in motor neurons, under the control of Scer\GAL4^D42, results in a moderate increase in synapse number.

Overexpression of InR^{Scer\UAS.Exel} under the control of Scer\GAL4⁷⁹⁶ induces supernumerary ellipsoid body neurons.

(Martin-Pena et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

InR^UAS.Exel, Scer\GAL4^AB1 has increased cell size | third instar larval stage phenotype, enhanceable by PIP4K²⁹

(Sharma et al., 2019)

InR^UAS.Exel, Scer\GAL4^ap-md544 has visible phenotype, enhanceable by Df(2R)Sesn-8A11/Df(2R)Sesn-8A11

(Lee et al., 2010)

Suppressed by

Statement

Reference

InR^UAS.Exel, Scer\GAL4^en-e16E has abnormal size | adult stage phenotype, suppressible by nclb^NIG.6751R, Scer\GAL4^en-e16E

(Liu et al., 2017)

NOT suppressed by

Statement

Reference

InR^UAS.Exel, Scer\GAL4^sd-SG29.1 has abnormal size phenotype, non-suppressible by Ide^UAS.cTa, Scer\GAL4^sd-SG29.1

(Tsuda et al., 2010)

Suppressor of

Statement

Reference

Scer\GAL4^Cg.PA/InR^UAS.Exel is a suppressor of decreased body size | pupal stage phenotype of Sgsf^KO

(Li et al., 2022)

Phenotype Manifest In

Enhanced by

Statement

Reference

InR^UAS.Exel, Scer\GAL4^AB1 has fat cell | third instar larval stage phenotype, enhanceable by PIP4K²⁹

(Sharma et al., 2019)

InR^UAS.Exel, Scer\GAL4^ap-md544 has wing blade phenotype, enhanceable by Df(2R)Sesn-8A11/Df(2R)Sesn-8A11

(Lee et al., 2010)

Suppressed by

Statement

Reference

InR^UAS.Exel, Scer\GAL4^en-e16E has wing posterior compartment phenotype, suppressible by nclb^NIG.6751R, Scer\GAL4^en-e16E

(Liu et al., 2017)

InR^UAS.Exel, Scer\GAL4^GMR.PF has eye phenotype, suppressible by HDAC3^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Lv et al., 2012)

InR^UAS.Exel, Scer\GAL4^GMR.PF has ommatidium phenotype, suppressible by HDAC3^RNAi.Sym.UAS, Scer\GAL4^GMR.PF

(Lv et al., 2012)

NOT suppressed by

Statement

Reference

InR^UAS.Exel, Scer\GAL4^sd-SG29.1 has wing phenotype, non-suppressible by Ide^UAS.cTa, Scer\GAL4^sd-SG29.1

(Tsuda et al., 2010)

Suppressor of

Statement

Reference

Scer\GAL4^Tub.PU/InR^UAS.Exel is a suppressor of intestinal stem cell | somatic clone phenotype of lin-28^Δ1

(Chen et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The increased wing posterior compartment area induced by the expression of InR^{Scer\UAS.Exel} under the control of Scer\GAL4^en-e16E is suppressed by the co-expression of nclb^NIG.6751R.

(Liu et al., 2017)

Expression of InR^{Scer\UAS.Exel} under the control of Scer\GAL4^tub.PU in lin-28^Δ1 clones in the adult midgut rescues the reduction in total cell number per clone and reduction in number of Dl-positive intestinal stem cells per clone in fed animals. There is also an increase in the number of mutant clones per intestine over tie which is consistent with increased symmetric renewal in the rescued animals.

(Chen et al., 2015)

Depletion of Hdac3 in the eye, through expression of Hdac3^{dsRNA.Sym.Scer\UAS} under the control of Scer\GAL4^GMR.PF, strongly suppresses the overgrown, disorganised eye phenotype (with increased ommatidial size) found upon expression of InR^{Scer\UAS.Exel} in the eye. These double-mutant flies exhibit a phenotype similar to Hdac3^{dsRNA.Sym.Scer\UAS} single mutants.

(Lv et al., 2012)

The growth-promoting effect of InR^UAS.Exel overexpression via Scer\GAL4^ap-md544 is enhanced in a homozygous Df(2R)Sesn-8A11-mutant background.

(Lee et al., 2010)

The InR^{Scer\UAS.Exel}-induced wing size phenotype is not suppressed by co-expressing Ide^Scer\UAS.cTa under the control of Scer\GAL4^sd-SG29.1.

(Tsuda et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

8262

y¹ w¹¹¹⁸; P{UAS-InR.Exel}2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

InR^{Scer\UAS.Exel}

InR^UAS.Exel

InR^WT

(Hong et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (29)

Report Sections

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