FlyBase Allele Report: Dmel\InR[K1409A.UAS]

Somatic clones expressing InR^K1409A.UAS under the control of Scer\GAL4^Tub.PU contain a smaller overall number of cells and intestinal stem cells in adult flies compared to controls, but maintain a wild-type ratio of stem cells/clone.

(Gervais et al., 2019)

Expression of InR^K1409A.UAS under the control of Scer\GAL4^Su(H).GBE (in combination with tub-Gal80[ts] to restrict expression to the adult stage) leads to a decrease in the cell size of enteroblasts in adult guts when compared to controls.

(Rojas Villa et al., 2019)

Individuals expressing InR^K1409A.UAS under the control of Scer\GAL4^GMR11F02 show significant decreases in wing size and wing cell size and number, as compared to controls.

(Shinoda et al., 2019)

Posterior dorsocentral bristle neurons expressing InR^K1409A.UAS under the control of Scer\GAL4^pnr-MD237 show a significantly decreased terminal arbor territory and significantly fewer synapses (Syt1 puncta) on the contralateral collateral branch, as compared to controls.

(Urwyler et al., 2019)

Adulthood-generated midgut clones expressing InR^K1409A.UAS under the control of Scer\GAL4^Tub.PU are rare and very small, and do not show significant changes in the proportion of intestinal stem cells, as compared to control clones.

(Andriatsilavo et al., 2018)

Expression of InR^K1409A.UAS under the control of Scer\GAL4^Tub.PU in MARCM clones leads to a significant decrease in midgut cell number when compared to control adults.

(Mattila et al., 2018)

The expression of InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^nub.PU leads to the adult wing showing a severe decrease in size, associated with a decrease in cell number and with a significant decrease in cell size, as compared to controls.

(Hevia et al., 2017)

Expression of InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^hh.PU results in decreased size of the posterior compartment in third instar larval wing discs.

(Romero-Pozuelo et al., 2017)

Pre-starved adult flies expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^elav-C155 display an over-feeding behavior (significant increase in food consumption) upon re-feeding compared to controls. It does not however affect food choice of unstarved flies in a two-choice feeding assay: similar to controls, the flies display a preference for tryptone-supplemented (source of amino-acids) food over a sucrose-only food after sucrose pre-feeding.

(Sun et al., 2017)

Expressing InR^K1409A.UAS under the control of Scer\GAL4^en.PU has no effect on cell death in wing discs.

(Hall and Verheyen, 2015)

Expression of InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^{αTub84B.Switch.PK} (limited to the adult stages using RU486) significantly increases lifespan.

(Obata and Miura, 2015)

Expression of InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^Cg.PA does not interfere with normal development of the larval fat body or viability of the flies, and has no major effect on fat storage, but the average size of larval fat body cells is substantially reduced, as compared to controls.

(Schmitt et al., 2015)

Expression via Scer\GAL4^wor.PA and Scer\GAL80^ase.PN does not prevent the normal cell cycle exit of pupal neuroblasts.

(Homem et al., 2014)

Flies expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.G32 show typical circadian rhythmicity under 12:12 hour light:dark (LD) and constant dark (DD) conditions. However, in the mutants day activity is significantly increased, whereas night activity is significantly reduced ,a pattern that is maintained as the flies age. Wakefulness (average activity per awake minute) is not significantly altered, suggesting that they have a greater number of active periods during the day.

At all ages tested, flies expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.G32 sleep more at night and less by day than controls. In addition, they have fewer waking periods, and hence sleep bouts, during both day and night, and longer night sleep bouts than are seen in controls.

The increase in sleep fragmentation seen in control flies is less severe in flies expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.G32. Night sleep duration does not change and day sleep duration stays the same. Day and night sleep bouts do not increase with age.

(Metaxakis et al., 2014)

Pupal volume is reduced compared to wild-type in animals expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^tub.PU.

(Okamoto et al., 2013)

Expression of InR^{K1409A.Scer\UAS} under the control of two copies of Scer\GAL4^ppk.PG produces dendrite pruning defects in ddaC neurons at 16 hours after puparium formation. No difference is seen in white prepupae.

(Wong et al., 2013)

Flies expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^sNPF-R.2.5 show significantly increased food consumption compared to controls.

(Hong et al., 2012)

No obvious photoreceptor phenotypes are seen when InR^{K1409A.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF.

(Mann et al., 2012)

Expression of InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.G32 in wild-type flies leads to a 10-15% increase in median lifespan and a 6-10% increase in maximum lifespan.

Expression of InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.Switch.PT, induced by RU486, increases median lifespan by 24% and maximum lifespan by 5%.

Scer\GAL4^da.G32>InR^{K1409A.Scer\UAS} females show reduced egg laying compared with controls.

Flies expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.G32 display a delay in egg-adult development time by over 24 hours compared to controls. These flies also show a significant reduction in both body weight and wing size.

Flies expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.G32 all survive for significantly longer on food supplemented with 20mM paraquat compared to controls.

Flies expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.G32 survive for longer in the presence of DTT, compared to controls.

Expression of InR^{K1409A.Scer\UAS} in the developing eye under the control of Scer\GAL4^ey.PH inhibits growth, leading to a smaller eye than in controls.

(Slack et al., 2011)

Central nervous system neuroblasts of fed larvae expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^nab show a reduction in EdU incorporation compared to controls.

(Sousa-Nunes et al., 2011)

Female flies expressing InR^{K1409A.Scer\UAS} ubiquitously under the control of Scer\GAL4^da.G32 show a significantly reduced re-mating rate 24 hours after mating to wild-type flies, compared to control flies.

Female flies expressing InR^{K1409A.Scer\UAS} ubiquitously post-development under the control of Scer\GAL4^{Act5C.Switch.PR} show a significantly reduced re-mating rate 24 hours after mating to wild-type flies, compared to control flies.

(Wigby et al., 2011)

Compared with controls, the age-related dysplasia of the intestinal epithelium is strongly reduced in flies expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^esg-NP5130 and Scer\GAL80^ts.αTub84B.

Compared with controls, female flies expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^bun-GSG5961 show a moderate, but significant, reduction in intestinal cell proliferation at old age. These flies are significantly longer lived when exposed to RU486 than isogenic siblings exposed to mock treatment.

(Biteau et al., 2010)

Expression of InR^{K1409A.Scer\UAS} driven by Scer\GAL4^ap-md544 in dorsal cells of the wing causes a phenotype in which the wing bends upward.

(Lee et al., 2010)

Mushroom body neuroblasts persist slightly longer than normal in animals expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^wor.PA.

(Siegrist et al., 2010)

Female flies expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.G32 weigh significantly less, and lay fewer eggs, than sibling controls. Adult fat body morphology is altered in these animals, displaying a misshapen and shrunken appearance. Mutant flies are short-lived. Very few mutant male flies eclose, and those that do have a much reduced life-span.

The affect of expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.G32 is less pronounced but still significant if the female flies are infected with Wolbachia. Reductions in body weight and the number of eggs laid is observed, however infected female flies display normal adult fat body morphology. Infected mutant flies have a large extension of median and maximum life-span. Infected mutant male flies display a slight reduction in median lifespan.

Female flies infected with Wolbachia expressing InR^{K1409A.Scer\UAS} in the adult fat body under the control of Scer\GAL4^Switch1.106 display a normal lifespan. Removal of the Wolbachia from these flies results in an extension of lifespan.

(Ikeya et al., 2009)

The oenocytes of larvae expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^fat contain lipid droplets regardless of whether the larvae are fed a standard diet or are deprived of food (wild-type oenocytes only accumulate lipid droplets when they are starved)

(Kohyama-Koganeya et al., 2008)

Overexpression of InR^{K1409A.Scer\UAS} under the control of Scer\GAL4⁷⁹⁶ does not induce any significant effect.

(Martin-Pena et al., 2006)

When fed ad libitum, third instar larvae expressing InR^{K1409A.Scer\UAS}, under the control of Scer\GAL4^NPFR1.6.6 display hyperactive feeding on solid food, similar to control third instar larvae deprived of food for 40 minutes. These third instar larvae do not exhibit significant changes in the intake rate of the richer liquid food, relative to controls.

(Wu et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

InR^K1409A.UAS, Scer\GAL4^nub.PU has abnormal size | adult stage phenotype, enhanceable by Smox^NIG.2262R, Scer\GAL4^nub.PU

(Hevia et al., 2017)

InR^K1409A.UAS, Scer\GAL4^ap-md544 has visible phenotype, enhanceable by Sesn^d04539, Scer\GAL4^ap-md544

(Lee et al., 2010)

NOT Enhanced by

Statement

Reference

InR^K1409A.UAS, Scer\GAL4^elav-C155 has abnormal starvation stress response | adult stage phenotype, non-enhanceable by mir-137^CR

(Saedi et al., 2024)

InR^K1409A.UAS, Scer\GAL4^elav-C155 has abnormal starvation stress response | adult stage phenotype, non-enhanceable by mir-137^KO

(Saedi et al., 2024)

InR^K1409A.UAS, Scer\GAL4^{DIP-γ-MI03222-GAL4} has abnormal neuroanatomy | adult stage | somatic clone phenotype, non-enhanceable by mTor^ΔP/mTor^ΔP

(Luo et al., 2020)

InR^K1409A.UAS, Scer\GAL4^nub.PU has decreased cell size | adult stage phenotype, non-enhanceable by Smox^SDVD.UAS, Scer\GAL4^nub.PU

(Hevia et al., 2017)

Suppressed by

Statement

Reference

InR^K1409A.UAS, Scer\GAL4^VP16.bam has decreased size | spermatogenesis phenotype, suppressible | partially by Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^VP16.bam

(Azuma et al., 2021)

InR^K1409A.UAS, Scer\GAL4^VP16.bam has decreased size | spermatogenesis phenotype, suppressible | partially by Ras85D^V12.UAS, Scer\GAL4^VP16.bam

(Azuma et al., 2021)

InR^K1409A.UAS, Scer\GAL4^spok.1.45 has abnormal developmental rate phenotype, suppressible by Alk^{act.UAS.Tag:HA}, Scer\GAL4^spok.1.45

(Pan and O'Connor, 2021)

InR^K1409A.UAS, Scer\GAL4^Su(H).GBE has decreased cell size | adult stage phenotype, suppressible by zfh2^EAB, Scer\GAL4^Su(H).GBE

(Rojas Villa et al., 2019)

InR^K1409A.UAS, Scer\GAL4^GMR11F02 has abnormal size | adult stage phenotype, suppressible | partially by Diap1[+]/Diap1⁴

(Shinoda et al., 2019)

InR^K1409A.UAS, Scer\GAL4^GMR11F02 has decreased cell size | adult stage phenotype, suppressible | partially by Diap1[+]/Diap1⁴

(Shinoda et al., 2019)

InR^K1409A.UAS, Scer\GAL4^GMR11F02 has decreased cell number | adult stage phenotype, suppressible | partially by Diap1[+]/Diap1⁴

(Shinoda et al., 2019)

InR^K1409A.UAS, Scer\GAL4^nub.PU has abnormal size | adult stage phenotype, suppressible by Smox^SDVD.UAS, Scer\GAL4^nub.PU

(Hevia et al., 2017)

InR^K1409A.UAS, Scer\GAL4^nub.PU has decreased cell number | adult stage phenotype, suppressible by Smox^SDVD.UAS, Scer\GAL4^nub.PU

(Hevia et al., 2017)

InR^K1409A.UAS, Scer\GAL4^{αTub84B.Switch.PK} has long lived | RU486 conditional phenotype, suppressible | partially by Gnmt^GD10563, Scer\GAL4^{αTub84B.Switch.PK}

(Obata and Miura, 2015)

InR^K1409A.UAS, Scer\GAL4^da.G32 has abnormal sleep phenotype, suppressible | partially by foxo[+]/foxo^Δ94

(Metaxakis et al., 2014)

InR^K1409A.UAS, Scer\GAL4^da.Switch.PT has long lived phenotype, suppressible | partially by foxo^Δ94

(Slack et al., 2011)

InR^K1409A.UAS, Scer\GAL4^da.G32 has abnormal developmental rate phenotype, suppressible by foxo^Δ94

(Slack et al., 2011)

InR^K1409A.UAS, Scer\GAL4^da.Switch.PT has long lived | RU486 conditional phenotype, suppressible by foxo^Δ94

(Slack et al., 2011)

NOT suppressed by

Statement

Reference

InR^K1409A.UAS, Scer\GAL4^{DIP-γ-MI03222-GAL4} has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by mTor^ΔP/mTor^ΔP

(Luo et al., 2020)

InR^K1409A.UAS, Scer\GAL4^elav-C155 has abnormal feeding behavior | adult stage phenotype, non-suppressible by fit^UAS.Tag:HA, Scer\GAL4^elav-C155

(Sun et al., 2017)

Enhancer of

Statement

Reference

InR^K1409A.UAS, Scer\GAL4^GMR.PFa is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PFa, Zzzz\GGGGCC^36.UAS

(Atilano et al., 2021)

InR^K1409A.UAS, Scer\GAL4^GMR.PFa is an enhancer of decreased size | adult stage phenotype of Scer\GAL4^GMR.PFa, Zzzz\GGGGCC^36.UAS

(Atilano et al., 2021)

InR^K1409A.UAS, Scer\GAL4^{elav.Switch.PO} is an enhancer of short lived | RU486 conditional phenotype of Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS

(Atilano et al., 2021)

InR^K1409A.UAS, Scer\GAL4^nub.PU is an enhancer of abnormal size | adult stage phenotype of Scer\GAL4^nub.PU, Smox^NIG.2262R

(Hevia et al., 2017)

InR^K1409A.UAS, Scer\GAL4^ppk.PG is an enhancer of abnormal neuroanatomy | pupal stage phenotype of Scer\GAL4^ppk.PG, SkpA^GD9251

(Wong et al., 2013)

NOT Enhancer of

Statement

Reference

Scer\GAL4^elav-C155/InR^K1409A.UAS is a non-enhancer of abnormal starvation stress response | adult stage | semidominant phenotype of mir-137^CR

(Saedi et al., 2024)

Scer\GAL4^elav-C155/InR^K1409A.UAS is a non-enhancer of abnormal starvation stress response | adult stage | semidominant phenotype of mir-137^KO

(Saedi et al., 2024)

InR^K1409A.UAS, Scer\GAL4^Su(H).GBE is a non-enhancer of increased cell size | adult stage phenotype of Scer\GAL4^Su(H).GBE, zfh2^EAB

(Rojas Villa et al., 2019)

InR^K1409A.UAS, Scer\GAL4^Su(H).GBE is a non-enhancer of increased occurrence of cell division | adult stage phenotype of Scer\GAL4^Su(H).GBE, zfh2^EAB

(Rojas Villa et al., 2019)

InR^K1409A.UAS, Scer\GAL4^nub.PU is a non-enhancer of decreased cell size | adult stage phenotype of Scer\GAL4^nub.PU, Smox^SDVD.UAS

(Hevia et al., 2017)

InR^K1409A.UAS, Scer\GAL4^nub.PU is a non-enhancer of decreased cell number | adult stage phenotype of Scer\GAL4^nub.PU, Smox^NIG.2262R

(Hevia et al., 2017)

InR^K1409A.UAS, Scer\GAL4^GMR.PF is a non-enhancer of abnormal neuroanatomy phenotype of Scer\GAL4^GMR.PF, gogo^DDD.UAS

(Mann et al., 2012)

Suppressor of

Statement

Reference

InR^K1409A.UAS/Scer\GAL4^Cg.PA is a suppressor of increased mortality during development phenotype of Ras85D^V12.GMR

(Okada et al., 2023)

Scer\GAL4^fat/InR^K1409A.UAS is a suppressor of increased mortality during development phenotype of Ras85D^V12.GMR

(Okada et al., 2023)

InR^K1409A.UAS, Scer\GAL4^repo.PU is a suppressor of increased cell number | larval stage phenotype of Ilp6^UAS.cUa, Scer\GAL4^repo.PU

(Harrison et al., 2021)

InR^K1409A.UAS, Scer\GAL4^{repo.Switch.2301} is a suppressor | partially of short lived | RU486 conditional phenotype of Hsap\HTT^{N548.Q128.UAS}, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

InR^K1409A.UAS/Scer\GAL4^Tub.PU is a suppressor of increased cell number | recessive | somatic clone | adult stage phenotype of kis^10D26

(Gervais et al., 2019)

InR^K1409A.UAS/Scer\GAL4^GMR11F02 is a suppressor of abnormal size | adult stage phenotype of Diap1⁴

(Shinoda et al., 2019)

InR^K1409A.UAS/Scer\GAL4^GMR11F02 is a suppressor of increased cell number | dominant | adult stage phenotype of Diap1⁴

(Shinoda et al., 2019)

InR^K1409A.UAS, Scer\GAL4^esg.PU is a suppressor | partially of increased occurrence of cell division | adult stage | progressive phenotype of SH3PX1^HMJ21552, Scer\GAL4^esg.PU

(Zhang et al., 2019)

InR^K1409A.UAS, Scer\GAL4^nub.PU is a suppressor of increased cell size | adult stage phenotype of Scer\GAL4^nub.PU, Smox^NIG.2262R

(Hevia et al., 2017)

InR^K1409A.UAS, Scer\GAL4^nub.PU is a suppressor of abnormal size | adult stage phenotype of Scer\GAL4^nub.PU, Smox^SDVD.UAS

(Hevia et al., 2017)

InR^K1409A.UAS, Scer\GAL4^nub.PU is a suppressor of increased cell number | adult stage phenotype of Scer\GAL4^nub.PU, Smox^SDVD.UAS

(Hevia et al., 2017)

InR^K1409A.UAS, Scer\GAL4^elav-C155 is a suppressor of abnormal feeding behavior | adult stage phenotype of Scer\GAL4^elav-C155, fit^UAS.Tag:HA

(Sun et al., 2017)

InR^K1409A.UAS, Scer\GAL4^ppk.PG is a suppressor | partially of abnormal neuroanatomy | pupal stage phenotype of Cul1^GD9650, Scer\GAL4^ppk.PG

(Wong et al., 2013)

InR^K1409A.UAS, Scer\GAL4^ppk.PG is a suppressor | partially of abnormal neuroanatomy | pupal stage phenotype of Scer\GAL4^ppk.PG, SkpA^GD9251

(Wong et al., 2013)

InR^K1409A.UAS/Scer\GAL4^ppk.PG is a suppressor of abnormal neuroanatomy | somatic clone | pupal stage phenotype of Cul1^EX

(Wong et al., 2013)

InR^K1409A.UAS, Scer\GAL4^GMR.PF is a suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^GMR.PF, gogo^Scer\UAS.T1

(Mann et al., 2012)

NOT Suppressor of

Statement

Reference

InR^K1409A.UAS/Scer\GAL4^Desat1.PB is a non-suppressor of increased mortality during development phenotype of Ras85D^V12.GMR

(Okada et al., 2023)

InR^K1409A.UAS/Scer\GAL4^esg.PU is a non-suppressor of increased mortality during development phenotype of Ras85D^V12.GMR

(Okada et al., 2023)

InR^K1409A.UAS/Scer\GAL4^GMR.PU is a non-suppressor of increased mortality during development phenotype of Ras85D^V12.GMR

(Okada et al., 2023)

InR^K1409A.UAS/Scer\GAL4^Mef2.PR is a non-suppressor of increased mortality during development phenotype of Ras85D^V12.GMR

(Okada et al., 2023)

InR^K1409A.UAS/Scer\GAL4^nub.PU is a non-suppressor of increased mortality during development phenotype of Ras85D^V12.GMR

(Okada et al., 2023)

InR^K1409A.UAS, Scer\GAL4^Su(H).GBE is a non-suppressor of increased cell size | adult stage phenotype of Scer\GAL4^Su(H).GBE, zfh2^EAB

(Rojas Villa et al., 2019)

InR^K1409A.UAS, Scer\GAL4^Su(H).GBE is a non-suppressor of increased occurrence of cell division | adult stage phenotype of Scer\GAL4^Su(H).GBE, zfh2^EAB

(Rojas Villa et al., 2019)

InR^K1409A.UAS, Scer\GAL4^GMR.PF is a non-suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^GMR.PF, gogo^DDD.UAS

(Mann et al., 2012)

InR^K1409A.UAS/Scer\GAL4^da.G32 is a non-suppressor of viable phenotype of foxo^Δ94

(Slack et al., 2011)

InR^K1409A.UAS/Scer\GAL4^da.Switch.PT is a non-suppressor of viable | RU486 conditional phenotype of foxo^Δ94

(Slack et al., 2011)

Other

Statement

Reference

InR^K1409A.UAS, Lpin^GD14004, Scer\GAL4^Cg.PA has increased cell size phenotype

(Schmitt et al., 2015)

InR^K1409A.UAS, Lpin^GD14004, Scer\GAL4^Cg.PA has lethal - all die before end of P-stage phenotype

(Schmitt et al., 2015)

InR^K1409A.UAS, Lpin^GD14004, Scer\GAL4^Cg.PA has majority die during larval stage phenotype

(Schmitt et al., 2015)

InR^K1409A.UAS, Scer\GAL4^da.G32, foxo^Δ94 has viable phenotype

(Metaxakis et al., 2014)

InR^K1409A.UAS, Scer\GAL4^da.G32, foxo[+]/foxo^Δ94 has abnormal sleep phenotype

(Metaxakis et al., 2014)

Phenotype Manifest In

Enhanced by

Statement

Reference

InR^K1409A.UAS, Scer\GAL4^nub.PU has wing phenotype, enhanceable by Smox^NIG.2262R, Scer\GAL4^nub.PU

(Hevia et al., 2017)

InR^K1409A.UAS, Scer\GAL4^ap-md544 has wing blade phenotype, enhanceable by Sesn^d04539, Scer\GAL4^ap-md544

(Lee et al., 2010)

NOT Enhanced by

Statement

Reference

InR^K1409A.UAS, Scer\GAL4^{DIP-γ-MI03222-GAL4} has distal medullary amacrine neuron Dm8 | adult stage | somatic clone phenotype, non-enhanceable by mTor^ΔP/mTor^ΔP

(Luo et al., 2020)

InR^K1409A.UAS, Scer\GAL4^{DIP-γ-MI03222-GAL4} has dendrite | adult stage | somatic clone phenotype, non-enhanceable by mTor^ΔP/mTor^ΔP

(Luo et al., 2020)

Suppressed by

Statement

Reference

InR^K1409A.UAS, Scer\GAL4^VP16.bam has spermatocyte phenotype, suppressible | partially by Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^VP16.bam

(Azuma et al., 2021)

InR^K1409A.UAS, Scer\GAL4^VP16.bam has spermatocyte phenotype, suppressible | partially by Ras85D^V12.UAS, Scer\GAL4^VP16.bam

(Azuma et al., 2021)

InR^K1409A.UAS, Scer\GAL4^GMR11F02 has wing phenotype, suppressible | partially by Diap1[+]/Diap1⁴

(Shinoda et al., 2019)

InR^K1409A.UAS, Scer\GAL4^nub.PU has wing phenotype, suppressible by Smox^SDVD.UAS, Scer\GAL4^nub.PU

(Hevia et al., 2017)

InR^K1409A.UAS, Scer\GAL4^ey.PH has eye phenotype, suppressible by foxo^Δ94

(Slack et al., 2011)

NOT suppressed by

Statement

Reference

InR^K1409A.UAS, Scer\GAL4^{DIP-γ-MI03222-GAL4} has distal medullary amacrine neuron Dm8 | somatic clone | adult stage phenotype, non-suppressible by mTor^ΔP/mTor^ΔP

(Luo et al., 2020)

InR^K1409A.UAS, Scer\GAL4^{DIP-γ-MI03222-GAL4} has dendrite | somatic clone | adult stage phenotype, non-suppressible by mTor^ΔP/mTor^ΔP

(Luo et al., 2020)

Enhancer of

Statement

Reference

InR^K1409A.UAS, Scer\GAL4^GMR.PFa is an enhancer of eye phenotype of Scer\GAL4^GMR.PFa, Zzzz\GGGGCC^36.UAS

(Atilano et al., 2021)

InR^K1409A.UAS, Scer\GAL4^nub.PU is an enhancer of wing phenotype of Scer\GAL4^nub.PU, Smox^NIG.2262R

(Hevia et al., 2017)

InR^K1409A.UAS, Scer\GAL4^ppk.PG is an enhancer of larval dorsal multidendritic neuron ddaC | pupal stage phenotype of Scer\GAL4^ppk.PG, SkpA^GD9251

(Wong et al., 2013)

NOT Enhancer of

Statement

Reference

InR^K1409A.UAS, Scer\GAL4^Su(H).GBE is a non-enhancer of enteroblast | adult stage phenotype of Scer\GAL4^Su(H).GBE, zfh2^EAB

(Rojas Villa et al., 2019)

InR^K1409A.UAS, Scer\GAL4^Su(H).GBE is a non-enhancer of adult gut phenotype of Scer\GAL4^Su(H).GBE, zfh2^EAB

(Rojas Villa et al., 2019)

InR^K1409A.UAS, Scer\GAL4^Su(H).GBE is a non-enhancer of intestinal stem cell | adult stage phenotype of Scer\GAL4^Su(H).GBE, zfh2^EAB

(Rojas Villa et al., 2019)

InR^K1409A.UAS, Scer\GAL4^nub.PU is a non-enhancer of wing phenotype of Scer\GAL4^nub.PU, Smox^NIG.2262R

(Hevia et al., 2017)

InR^K1409A.UAS, Scer\GAL4^GMR.PF is a non-enhancer of photoreceptor cell R8 phenotype of Scer\GAL4^GMR.PF, gogo^DDD.UAS

(Mann et al., 2012)

InR^K1409A.UAS, Scer\GAL4^GMR.PF is a non-enhancer of medulla layer M1 phenotype of Scer\GAL4^GMR.PF, gogo^DDD.UAS

(Mann et al., 2012)

Suppressor of

Statement

Reference

InR^K1409A.UAS, Scer\GAL4^repo.PU is a suppressor of larval ventral nerve cord phenotype of Ilp6^UAS.cUa, Scer\GAL4^repo.PU

(Harrison et al., 2021)

InR^K1409A.UAS, Scer\GAL4^repo.PU is a suppressor of larval glial cell | increased number | larval stage phenotype of Ilp6^UAS.cUa, Scer\GAL4^repo.PU

(Harrison et al., 2021)

InR^K1409A.UAS/Scer\GAL4^Tub.PU is a suppressor of adult midgut epithelium | somatic clone phenotype of kis^10D26

(Gervais et al., 2019)

InR^K1409A.UAS/Scer\GAL4^Tub.PU is a suppressor of intestinal stem cell | somatic clone | adult stage phenotype of kis^10D26

(Gervais et al., 2019)

InR^K1409A.UAS/Scer\GAL4^GMR11F02 is a suppressor of wing phenotype of Diap1⁴

(Shinoda et al., 2019)

InR^K1409A.UAS, Scer\GAL4^nub.PU is a suppressor of wing phenotype of Scer\GAL4^nub.PU, Smox^NIG.2262R

(Hevia et al., 2017)

InR^K1409A.UAS, Scer\GAL4^nub.PU is a suppressor of wing phenotype of Scer\GAL4^nub.PU, Smox^SDVD.UAS

(Hevia et al., 2017)

InR^K1409A.UAS, Scer\GAL4^ppk.PG is a suppressor | partially of larval dorsal multidendritic neuron ddaC | pupal stage phenotype of Cul1^GD9650, Scer\GAL4^ppk.PG

(Wong et al., 2013)

InR^K1409A.UAS, Scer\GAL4^ppk.PG is a suppressor | partially of larval dorsal multidendritic neuron ddaC | pupal stage phenotype of Scer\GAL4^ppk.PG, SkpA^GD9251

(Wong et al., 2013)

InR^K1409A.UAS/Scer\GAL4^ppk.PG is a suppressor of larval dorsal multidendritic neuron ddaC | somatic clone | pupal stage phenotype of Cul1^EX

(Wong et al., 2013)

InR^K1409A.UAS, Scer\GAL4^GMR.PF is a suppressor of photoreceptor cell R8 phenotype of Scer\GAL4^GMR.PF, gogo^Scer\UAS.T1

(Mann et al., 2012)

NOT Suppressor of

Statement

Reference

InR^K1409A.UAS, Scer\GAL4^Su(H).GBE is a non-suppressor of intestinal stem cell | adult stage phenotype of Scer\GAL4^Su(H).GBE, zfh2^EAB

(Rojas Villa et al., 2019)

InR^K1409A.UAS, Scer\GAL4^Su(H).GBE is a non-suppressor of enteroblast | adult stage phenotype of Scer\GAL4^Su(H).GBE, zfh2^EAB

(Rojas Villa et al., 2019)

InR^K1409A.UAS, Scer\GAL4^Su(H).GBE is a non-suppressor of adult gut phenotype of Scer\GAL4^Su(H).GBE, zfh2^EAB

(Rojas Villa et al., 2019)

InR^K1409A.UAS, Scer\GAL4^GMR.PF is a non-suppressor of photoreceptor cell R8 phenotype of Scer\GAL4^GMR.PF, gogo^DDD.UAS

(Mann et al., 2012)

InR^K1409A.UAS, Scer\GAL4^GMR.PF is a non-suppressor of medulla layer M1 phenotype of Scer\GAL4^GMR.PF, gogo^DDD.UAS

(Mann et al., 2012)

Other

Statement

Reference

InR^K1409A.UAS, Lpin^GD14004, Scer\GAL4^Cg.PA has nucleus | larval stage phenotype

(Schmitt et al., 2015)

InR^K1409A.UAS, Lpin^GD14004, Scer\GAL4^Cg.PA has embryonic/larval fat body | larval stage phenotype

(Schmitt et al., 2015)

InR^K1409A.UAS, Lpin^GD14004, Scer\GAL4^Cg.PA has lipid droplet | larval stage phenotype

(Schmitt et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Diap1⁴ heterozygosity ameliorates the wing defects induced by the expression of InR^K1409A.UAS under the control of Scer\GAL4^GMR11F02 (decreased wing size and decreases in wing cell size and number).

(Shinoda et al., 2019)

The double co-expression of InR^{K1409A.Scer\UAS} and Smox^{SDVD.Scer\UAS} under the control of Scer\GAL4^nub.PU suppresses the wing size and wing cell number defects induced by the single expression conditions. The co-expression of InR^{K1409A.Scer\UAS} does not affect the decreased wing cell size induced by the expression of Smox^{SDVD.Scer\UAS} under the control of Scer\GAL4^nub.PU.

The double co-expression of Smox^NIG.2262R and InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^nub.PU (together with Dicer-2, for efficient RNAi) leads to a more severe decrease in wing size compared to all corresponding single expression conditions; the co-expression of InR^{K1409A.Scer\UAS} suppresses the increased wing cell size, but does not affect the decreased wing cell number, induced by the expression of Smox^NIG.2262R under the control of Scer\GAL4^nub.PU (together with Dicer-2, for efficient RNAi).

(Hevia et al., 2017)

The overfeeding behavior observed in pre-starved adult flies expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^elav-C155 upon re-feeding is not suppressed by co-expression of fit^{Scer\UAS.T:Ivir\HA1}.

The decrease in preference for tryptone-supplemented food over a sucrose only food characteristic for unstarved adult flies expressing fit^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^elav-C155 in a two-way choice assay is suppressed by co-expression of InR^{K1409A.Scer\UAS}.

(Sun et al., 2017)

Expression of Gnmt^{miRNA.Scer\UAS} partially suppresses the increase in lifespan seen when InR^{K1409A.Scer\UAS} is expressed under the control of Scer\GAL4^{αTub84B.Switch.PK} (limited to the adult stages using RU486).

(Obata and Miura, 2015)

Co-expression of InR^{K1409A.Scer\UAS} and Lpin^GD14004 under the control of Scer\GAL4^Cg.PA leads to a majority of animals dying during larval development, with none reaching adulthood, and larvae exhibit a severely underdeveloped fat body, with greatly enlarged and rounded fat body cells that have enlarged nuclei and contain very small lipid droplets, as compared to controls.

(Schmitt et al., 2015)

One copy of foxo^Δ94 partially rescues the sleep defects seen in flies expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.G32, specifically affecting day, but not night time phenotypes. Mutants show strongly reduced day activity and increased day sleep duration without changes in wakefulness (average activity per awake minute), and the number of day sleep bouts does not differ significantly from controls.

(Metaxakis et al., 2014)

Expression of InR^{K1409A.Scer\UAS} dramatically suppresses the dendrite pruning defects seen in ddaC neurons expressing lin19^GD9650 under the control of Scer\GAL4^ppk.PG at 16 hours after pupariation.

Expression of InR^{K1409A.Scer\UAS} suppresses the dendrite pruning defects seen in ddaC neurons expressing skpA^GD9251 under the control of Scer\GAL4^ppk.PG at 16 hours after pupariation.

Expression of InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^ppk.PG fully strongly suppresses the dendrite pruning defects seen in lin19^EX mutant ddaC neuron clones at 16 hours after puparium formation. No difference is seen at the white prepupal stage.

(Wong et al., 2013)

Expression of InR^{K1409A.Scer\UAS} does not affect the R8 axon stopping phenotype seen when gogo^DDD.Scer\UAS is expressed under the control of Scer\GAL4^GMR.PF.

Expression of InR^{K1409A.Scer\UAS} completely suppresses the R8 photoreceptor phenotype seen when gogo^Scer\UAS.T1 is expressed under the control of Scer\GAL4^GMR.PF. No blob-like structures are seen in the medulla M1 layer.

(Mann et al., 2012)

Expression of InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.G32 does not affect the viability of foxo^Δ94 flies.

Expression of InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.G32 in foxo^Δ94 mutant flies results in an age-related increase in survival compared to controls, but this is less than in wild-type flies expressing InR^{K1409A.Scer\UAS}.

A foxo^Δ94 mutant background suppresses the extension in lifespan seen upon RU486-induced expression of InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.Switch.PT.

Adult onset ubiquitous expression of InR^{K1409A.Scer\UAS} under the control of the RU486-inducible Scer\GAL4^da.Switch.PT has no effect on the viability of foxo^Δ94 flies.

foxo^Δ94 mutant females expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.G32 show reduced egg laying compared with controls.

foxo^Δ94 mutant females expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.Switch.PT treated with RU486 lay significantly fewer eggs than their uninduced controls.

foxo^Δ94 mutant flies expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.G32 all survive for longer on food supplemented with 20mM paraquat compared to controls (but shorter compared to expression in a wild-type background).

A foxo^Δ94 background suppresses the DTT resistance seen in flies expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.G32.

A foxo^Δ94 background fully suppresses the tissue-restricted growth inhibition seen in the eye upon expression of InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^ey.PH.

Removal of foxo through a foxo^Δ94 background does not suppress the developmental delay or reduced body size seen in flies expressing InR^{K1409A.Scer\UAS} under the control of Scer\GAL4^da.G32.

(Slack et al., 2011)

Co-expression of Sesn^d04539 with InR^K1409A.UAS driven by Scer\GAL4^ap-md544 enhances the wing-bending phenotype of InR^K1409A.UAS.

Df(2R)Sesn-8A11 does not enhance the growth suppression resulting from Scer\GAL4^ap-md544-driven InR^K1409A.UAS expression in the wing.

(Lee et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (3)

Bloomington

8251

P{UAS-InR.K1409A}1, y¹ w¹¹¹⁸

8252

y¹ w¹¹¹⁸; P{UAS-InR.K1409A}2

8253

y¹ w¹¹¹⁸; P{UAS-InR.K1409A}3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

InR^DN

(Hall and Verheyen, 2015, Hong et al., 2012, Sousa-Nunes et al., 2011)

InR^{K1409A.Scer\UAS}

InR^K1409A.UAS

InR^K1409A

(Azuma et al., 2021, Hertenstein et al., 2021)

Ins-R^DN

(Romero-Pozuelo et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (84)

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