FlyBase Allele Report: Dmel\InR[A1325D.UAS]

General Information

Symbol

Dmel\InR^A1325D.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0156362

Feature type

allele

Associated gene

Dmel\InR

Associated Insertion(s)

Carried in Construct

P{UAS-InR.A1325D}

Also Known As

UAS-InR^CA, UAS-InR^A1325D, inR^CA, UAS-InR.A1325D, InRCA, InR^A1325D, UAS-InR^act, UAS-InR^AC

Key Links

Transgenic product class

missense_variant

(Parks, 2004.5.12)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Parks, 2004.5.12)

Mutagen

in vitro construct

(Parks, 2004.5.12)

Progenitor genotype

Carried in construct

P{UAS-InR.A1325D}

Cytology

Description

UAS regulatory sequences drive expression of a constitutively active form of InR (carries the amino acid replacement A1325D). The mutation mimics the human V938D protein variant of Longo et al., 1992 (PMID:1618747).

(Parks, 2004.5.12)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

InR

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of glucose metabolism disease

CEA

(Musselman et al., 2018)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates central nervous system cancer

modeled by Delta::N^ΔECN.UAS

(Voutyraki et al., 2023)

ameliorates frontotemporal dementia and/or amyotrophic lateral sclerosis 1

modeled by Zzzz\poly-GR^PO-100.UAS

(Atilano et al., 2021)

exacerbates cancer

modeled by Csk^Q156Stop, Ras85D^V12.UAS

(Hirabayashi et al., 2013)

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Pragati and Sarkar, 2024)

ameliorates cancer

modeled by Ras85D^V12.QUAS.cLa, scrib^{QUAS.HMS01490}

(Bakopoulos et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate, with Scer\GAL4^spok.1.45

(Pan and O'Connor, 2021)

abnormal size, with Scer\GAL4^en-e16E

(Wang et al., 2008)

abnormal size | adult stage, with Scer\GAL4^GMR.PF

(Cho et al., 2018)

abnormal size | cell autonomous | larval stage | somatic clone, with Scer\GAL4^Act5C.PP

(Roth et al., 2018)

abnormal size | larval stage | somatic clone, with Scer\GAL4^Act5C.PP

(Bakopoulos et al., 2023)

abnormal starvation stress response | adult stage, with Scer\GAL4^elav-C155

(Saedi et al., 2024)

abnormal starvation stress response | adult stage, with Scer\GAL4^ppl.PP

(Pathak and Varghese, 2021)

decreased cell number | adult stage | somatic clone, with Scer\GAL4^Tub.PU

(Mattila et al., 2018)

increased cell size | adult stage, with Scer\GAL4^Su(H).GBE

(Rojas Villa et al., 2019)

increased mortality, with Scer\GAL4^elav-C155

(Saedi et al., 2024)

increased occurrence of cell division | adult stage, with Scer\GAL4^NP5130

(Obata et al., 2018, Nie et al., 2015)

increased occurrence of cell division | adult stage, with Scer\GAL4^Su(H).GBE

(Rojas Villa et al., 2019)

increased occurrence of cell division | larval stage, with Scer\GAL4^nab

(Sousa-Nunes et al., 2011)

increased size | adult stage, with Scer\GAL4^en.PU

(Vega-Cuesta et al., 2020)

increased size | adult stage, with Scer\GAL4^GMR.PFa

(Morón-Oset et al., 2023, Atilano et al., 2021)

increased size | adult stage, with Scer\GAL4^salm.EPv

(Vega-Cuesta et al., 2020)

increased size | larval stage, with Scer\GAL4^spok.1.45

(Pan and O'Connor, 2021)

long lived | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Atilano et al., 2021)

visible, with Scer\GAL4^ap-md544

(Lee et al., 2010)

visible, with Scer\GAL4^en-e16E

(Wang et al., 2008)

visible, with Scer\GAL4^GMR.PF

(Lee et al., 2010)

visible | adult stage, with Scer\GAL4^en.PU

(Vega-Cuesta et al., 2020)

visible | adult stage, with Scer\GAL4^GMR.PF

(Cho et al., 2018)

visible | adult stage, with Scer\GAL4^GMR.PFa

(Atilano et al., 2021)

visible | adult stage, with Scer\GAL4^salm.EPv

(Vega-Cuesta et al., 2020)

Phenotype Manifest In

adult gut, with Scer\GAL4^Su(H).GBE

(Rojas Villa et al., 2019)

adult midgut, with Scer\GAL4^NP5130

(Obata et al., 2018, Nie et al., 2015)

adult midgut | somatic clone, with Scer\GAL4^Tub.PU

(Mattila et al., 2018)

embryonic/larval fat body | larval stage, with Scer\GAL4^Cg.PA

(Bakopoulos et al., 2023)

enteroblast | adult stage, with Scer\GAL4^Su(H).GBE

(Rojas Villa et al., 2019)

eye, with Scer\GAL4^GMR.PF

(Cho et al., 2018, Lee et al., 2010)

eye, with Scer\GAL4^GMR.PFa

(Morón-Oset et al., 2023, Atilano et al., 2021)

fat cell | cell autonomous | larval stage | somatic clone, with Scer\GAL4^Act5C.PP

(Roth et al., 2018)

intestinal stem cell | adult stage, with Scer\GAL4^Su(H).GBE

(Rojas Villa et al., 2019)

larval neuroblast, with Scer\GAL4^nab

(Sousa-Nunes et al., 2011)

neuroblast | third instar larval stage | nutrition conditional, with Scer\GAL4^insc-Mz1407

(Li et al., 2017)

nucleus | cell autonomous | larval stage | somatic clone, with Scer\GAL4^Act5C.PP

(Roth et al., 2018)

prothoracic gland | larval stage, with Scer\GAL4^spok.1.45

(Pan and O'Connor, 2021)

wing, with Scer\GAL4^salm.EPv

(Vega-Cuesta et al., 2020)

wing | posterior, with Scer\GAL4^en-e16E

(Wang et al., 2008)

wing blade, with Scer\GAL4^ap-md544

(Lee et al., 2010)

wing disc | somatic clone, with Scer\GAL4^Act5C.PP

(Bakopoulos et al., 2023)

wing posterior compartment, with Scer\GAL4^en.PU

(Vega-Cuesta et al., 2020)

Detailed Description

Statement

Reference

The expression of InR^A1325D.UAS under the control of Scer\GAL4^{elav.Switch.PO} during adulthood (induced by RU486 feeding) are long lived.

(Atilano et al., 2021)

Adults expressing InR^A1325D.UAS under the control of Scer\GAL4^ppl.PP are resistant to starvation.

(Pathak and Varghese, 2021)

Expression of InR^A1325D.UAS under the control of Scer\GAL4^en.PU leads to a larger posterior compartment of wing relative to the anterior one. Also, its expression under the control of Scer\GAL4^salm.EPv leads to a larger wing area included between the veins L2 and L5.

(Vega-Cuesta et al., 2020)

Expression of InR^A1325D.UAS under the control of Scer\GAL4^Su(H).GBE (in combination with tub-Gal80[ts] to restrict expression to the adult stage) leads to an increase in the cell size of enteroblasts and an increase in intestinal stem cell proliferation in adult guts when compared to controls.

(Rojas Villa et al., 2019)

Expression of InR^A1325D.UAS under the control of Scer\GAL4^GMR.PF leads to an increase in eye size when compared to controls.

(Cho et al., 2018)

Expression of InR^A1325D.UAS under the control of Scer\GAL4^Tub.PU in MARCM clones leads to a significant decrease in midgut cell number when compared to control adults.

(Mattila et al., 2018)

Expression of InR^{A1325D.Scer\UAS} under the control of Scer\GAL4^esg-NP5130 combined with leads to a significant increase in the number of proliferating (EdU+) cells in the adult posterior midgut.

(Obata et al., 2018)

Clonal expression of InR^A1325D.UAS under the control of Scer\GAL4^Act5C.PP in the larval fat body induces larger nuclei, as compared to neighboring control cells.

(Roth et al., 2018)

Expression of InR^{A1325D.Scer\UAS} under the control of Scer\GAL4^insc-Mz1407 is capable of driving central brain neuroblast reactivation in the absence of dietary amino acids.

(Li et al., 2017)

Expression of InR^{A1325D.Scer\UAS} under the control of Scer\GAL4^esg-NP5130 (in combination with a Gal80[ts] transgene to restrict expression to the adult stage) results in a significant increase in the number of mitotic cells in the midgut, as compared to controls.

(Nie et al., 2015)

Expression via Scer\GAL4^wor.PA and Scer\GAL80^ase.PN does not prevent the normal cell cycle exit of pupal neuroblasts.

(Homem et al., 2014)

Expression of InR^{A1325D.Scer\UAS} in the posterior wing compartment under the control of Scer\GAL4^en-e16E does not affect wing vein formation.

(Hahn et al., 2013)

Expression of InR^{A1325D.Scer\UAS} under the control of Scer\GAL4^GMR.PF does not produce R8 photoreceptor cell phenotypes.

(Mann et al., 2012)

Central nervous system neuroblasts of fed larvae expressing InR^{A1325D.Scer\UAS} under the control of Scer\GAL4^nab show an increase in EdU incorporation compared to controls.

Central nervous system neuroblasts of larvae expressing InR^{A1325D.Scer\UAS} under the control of Scer\GAL4^nab and raised on a diet lacking amino acids for 24 hours show an increase in EdU incorporation compared to controls.

(Sousa-Nunes et al., 2011)

Expression of InR^{A1325D.Scer\UAS} driven by Scer\GAL4^ap-md544 in dorsal cells of the wing causes an overgrowth phenotype in which the wing bends downward.

Overexpression of InR^{A1325D.Scer\UAS} via Scer\GAL4^GMR.PF causes a hyperplastic phenotype in the eye.

(Lee et al., 2010)

Third instar larvae expressing InR^{A1325D.Scer\UAS} under the control of Scer\GAL4^r4 have a significantly increased triglyceride/protein ratio compared to controls.

(Diangelo et al., 2009)

No scutellar bristle phenotypes are seen when InR^{A1325D.Scer\UAS} is expressed under the control of Scer\GAL4^sca-537.4. Expression in the wing under the control of Scer\GAL4^en-e16E leads to over-growth of the posterior compartment.

(Wang et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

InR^A1325D.UAS, Scer\GAL4^GMR.PFa has increased size | adult stage phenotype, non-enhanceable by Zzzz\poly-GA^100.UAS, Scer\GAL4^GMR.PFa

(Morón-Oset et al., 2023)

InR^A1325D.UAS, Scer\GAL4^Su(H).GBE has increased occurrence of cell division | adult stage phenotype, non-enhanceable by zfh2^GD4506, Scer\GAL4^Su(H).GBE

(Rojas Villa et al., 2019)

InR^A1325D.UAS, Scer\GAL4^Su(H).GBE has increased cell size | adult stage phenotype, non-enhanceable by zfh2^GD4506, Scer\GAL4^Su(H).GBE

(Rojas Villa et al., 2019)

InR^A1325D.UAS, Scer\GAL4^GMR.PF has abnormal size | adult stage phenotype, non-enhanceable by Prp4k^KK100483, Scer\GAL4^GMR.PF

(Cho et al., 2018)

InR^A1325D.UAS, Scer\GAL4^GMR.PF has visible | adult stage phenotype, non-enhanceable by Prp4k^KK100483, Scer\GAL4^GMR.PF

(Cho et al., 2018)

Suppressed by

Statement

Reference

InR^A1325D.UAS, Scer\GAL4^elav-C155 has abnormal starvation stress response | adult stage phenotype, suppressible | partially by mir-137^CR

(Saedi et al., 2024)

InR^A1325D.UAS, Scer\GAL4^elav-C155 has abnormal starvation stress response | adult stage phenotype, suppressible | partially by mir-137^KO

(Saedi et al., 2024)

InR^A1325D.UAS, Scer\GAL4^elav-C155 has increased mortality phenotype, suppressible | partially by mir-137^CR

(Saedi et al., 2024)

InR^A1325D.UAS, Scer\GAL4^elav-C155 has increased mortality phenotype, suppressible | partially by mir-137^KO

(Saedi et al., 2024)

InR^A1325D.UAS, Scer\GAL4^ppl.PP has abnormal starvation stress response | adult stage phenotype, suppressible by Edem1^GD3196, Scer\GAL4^ppl.PP

(Pathak and Varghese, 2021)

InR^A1325D.UAS, Scer\GAL4^salm.EPv has increased size | adult stage phenotype, suppressible by Ras85D^GD12553, Scer\GAL4^salm.EPv

(Vega-Cuesta et al., 2020)

InR^A1325D.UAS, Scer\GAL4^salm.EPv has visible | adult stage phenotype, suppressible by Ras85D^GD12553, Scer\GAL4^salm.EPv

(Vega-Cuesta et al., 2020)

InR^A1325D.UAS, Scer\GAL4^NP5130 has increased occurrence of cell division | adult stage phenotype, suppressible by Sams^KK107709, Scer\GAL4^NP5130

(Obata et al., 2018)

InR^A1325D.UAS, Scer\GAL4^Act5C.PP has abnormal size | somatic clone | cell autonomous | larval stage phenotype, suppressible | somatic clone by Tl^10b.UAS.cUa, Scer\GAL4^Act5C.PP

(Roth et al., 2018)

InR^A1325D.UAS, Scer\GAL4^NP5130 has increased occurrence of cell division | adult stage phenotype, suppressible by Madm^GD7155, Scer\GAL4^NP5130

(Nie et al., 2015)

InR^A1325D.UAS, Scer\GAL4^ap-md544 has visible phenotype, suppressible by Sesn^d04539, Scer\GAL4^ap-md544

(Lee et al., 2010)

InR^A1325D.UAS, Scer\GAL4^GMR.PF has visible phenotype, suppressible by Sesn^d04539, Scer\GAL4^GMR.PF

(Lee et al., 2010)

NOT suppressed by

Statement

Reference

InR^A1325D.UAS, Scer\GAL4^GMR.PFa has increased size | adult stage phenotype, non-suppressible by Zzzz\poly-GA^100.UAS, Scer\GAL4^GMR.PFa

(Morón-Oset et al., 2023)

InR^A1325D.UAS, Scer\GAL4^Su(H).GBE has increased cell size | adult stage phenotype, non-suppressible by zfh2^GD4506, Scer\GAL4^Su(H).GBE

(Rojas Villa et al., 2019)

InR^A1325D.UAS, Scer\GAL4^Su(H).GBE has increased occurrence of cell division | adult stage phenotype, non-suppressible by zfh2^GD4506, Scer\GAL4^Su(H).GBE

(Rojas Villa et al., 2019)

Enhancer of

Statement

Reference

InR^A1325D.UAS, Scer\GAL4^Act.PU is an enhancer of abnormal developmental rate | somatic clone phenotype of Csk^Q156Stop, Ras85D^V12.UAS, Scer\GAL4^Act.PU

(Hirabayashi et al., 2013)

InR^A1325D.UAS/Scer\GAL4^ppk.PG is an enhancer of abnormal neuroanatomy | pupal stage | somatic clone phenotype of Mical¹⁵²⁵⁶

(Wong et al., 2013)

InR^A1325D.UAS, Scer\GAL4^GMR.PF is an enhancer of abnormal neuroanatomy phenotype of Scer\GAL4^GMR.PF, gogo^Scer\UAS.T1

(Mann et al., 2012)

Suppressor of

Statement

Reference

InR^A1325D.UAS/Scer\GAL4^InR.PU is a suppressor of abnormal starvation stress response | semidominant | adult stage phenotype of mir-137^KO

(Saedi et al., 2024)

InR^A1325D.UAS, Scer\GAL4^GMR.PFa is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^GMR.PFa, Zzzz\poly-GA^400.UAS

(Morón-Oset et al., 2023)

InR^A1325D.UAS, Scer\GAL4^GMR.PFa is a suppressor of decreased size | adult stage phenotype of Scer\GAL4^GMR.PFa, Zzzz\poly-GA^400.UAS

(Morón-Oset et al., 2023)

InR^A1325D.UAS, Scer\GAL4^{elav.Switch.PO} is a suppressor | partially of decreased rate of adult locomotory behavior | RU486 conditional phenotype of Scer\GAL4^{elav.Switch.PO}, Zzzz\poly-GA^400.UAS

(Morón-Oset et al., 2023)

InR^A1325D.UAS, Scer\GAL4^{elav.Switch.PO} is a suppressor | partially of short lived | RU486 conditional phenotype of Scer\GAL4^{elav.Switch.PO}, Zzzz\poly-GA^400.UAS

(Morón-Oset et al., 2023)

InR^A1325D.UAS, Scer\GAL4^GMR.PFa is a suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.PFa, Zzzz\GGGGCC^36.UAS

(Atilano et al., 2021)

InR^A1325D.UAS, Scer\GAL4^GMR.PFa is a suppressor of decreased size | adult stage phenotype of Scer\GAL4^GMR.PFa, Zzzz\GGGGCC^36.UAS

(Atilano et al., 2021)

InR^A1325D.UAS, Scer\GAL4^{elav.Switch.PO} is a suppressor of short lived | RU486 conditional phenotype of Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS

(Atilano et al., 2021)

InR^A1325D.UAS, Scer\GAL4^{elav.Switch.PO} is a suppressor of abnormal locomotor behavior | adult stage | RU486 conditional phenotype of Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS

(Atilano et al., 2021)

InR^A1325D.UAS, Scer\GAL4^{elav.Switch.PO} is a suppressor of increased sleep | RU486 conditional phenotype of Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS

(Atilano et al., 2021)

InR^A1325D.UAS, Scer\GAL4^{elav.Switch.PO} is a suppressor of short lived | RU486 conditional phenotype of Scer\GAL4^{elav.Switch.PO}, Zzzz\poly-GR^PO-100.UAS

(Atilano et al., 2021)

InR^A1325D.UAS, Scer\GAL4^ppl.PP is a suppressor of abnormal starvation stress response | adult stage phenotype of Edem1^GD3196, Scer\GAL4^ppl.PP

(Pathak and Varghese, 2021)

InR^A1325D.UAS, Scer\GAL4^Act5C.PP is a suppressor | somatic clone of abnormal size | somatic clone | cell autonomous | larval stage phenotype of Scer\GAL4^Act5C.PP, Tl^10b.UAS.cUa

(Roth et al., 2018)

InR^A1325D.UAS is a suppressor of increased cell death | somatic clone | third instar larval stage phenotype of Csk^Q156Stop, Ras85D^V12.UAS, Scer\GAL4^Act.PU

(Hirabayashi et al., 2013)

NOT Suppressor of

Statement

Reference

InR^A1325D.UAS/Scer\GAL4^InR.PU is a non-suppressor of abnormal starvation stress response | semidominant | adult stage phenotype of mir-137^CR

(Saedi et al., 2024)

InR^A1325D.UAS, Scer\GAL4^Act5C.PP is a non-suppressor | somatic clone of decreased cell size | somatic clone | cell autonomous | larval stage phenotype of Scer\GAL4^Act5C.PP, Tl^10b.UAS.cUa

(Roth et al., 2018)

InR^A1325D.UAS, Scer\GAL4^Act5C.PP is a non-suppressor | somatic clone of abnormal cell growth | somatic clone | cell autonomous | larval stage phenotype of Scer\GAL4^Act5C.PP, Tl^10b.UAS.cUa

(Roth et al., 2018)

InR^A1325D.UAS, Scer\GAL4^sca-537.4 is a non-suppressor of visible phenotype of Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^sca-537.4

(Wang et al., 2008)

InR^A1325D.UAS, Scer\GAL4^en-e16E is a non-suppressor of visible phenotype of Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E

(Wang et al., 2008)

InR^A1325D.UAS, Scer\GAL4^en-e16E is a non-suppressor of abnormal size phenotype of Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E

(Wang et al., 2008)

InR^A1325D.UAS, Scer\GAL4^en-e16E is a non-suppressor of decreased cell size | adult stage phenotype of Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E

(Wang et al., 2008)

InR^A1325D.UAS, Scer\GAL4^en-e16E is a non-suppressor of decreased cell number | adult stage phenotype of Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E

(Wang et al., 2008)

Other

Statement

Reference

InR^A1325D.UAS, Scer\GAL4^elav-C155, mir-137^CR has abnormal starvation stress response | adult stage phenotype

(Saedi et al., 2024)

InR^A1325D.UAS, Scer\GAL4^elav-C155, mir-137^KO has abnormal starvation stress response | adult stage phenotype

(Saedi et al., 2024)

Edem1^GD3196, InR^A1325D.UAS, Scer\GAL4^ppl.PP has abnormal starvation stress response | adult stage phenotype

(Pathak and Varghese, 2021)

InR^A1325D.UAS, Scer\GAL4^Act5C.PP, Tl^10b.UAS.cUa has decreased cell size | somatic clone | cell autonomous | larval stage phenotype

(Roth et al., 2018)

InR^A1325D.UAS, Scer\GAL4^Act5C.PP, Tl^10b.UAS.cUa has abnormal cell growth | somatic clone | cell autonomous | larval stage phenotype

(Roth et al., 2018)

Csk^Q156Stop, InR^A1325D.UAS, Ras85D^V12.UAS, Scer\GAL4^Act.PU has majority die during third instar larval stage | somatic clone phenotype

(Hirabayashi et al., 2013)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

InR^A1325D.UAS, Scer\GAL4^GMR.PFa has eye phenotype, non-enhanceable by Zzzz\poly-GA^100.UAS, Scer\GAL4^GMR.PFa

(Morón-Oset et al., 2023)

InR^A1325D.UAS, Scer\GAL4^Su(H).GBE has adult gut phenotype, non-enhanceable by zfh2^GD4506, Scer\GAL4^Su(H).GBE

(Rojas Villa et al., 2019)

InR^A1325D.UAS, Scer\GAL4^Su(H).GBE has enteroblast | adult stage phenotype, non-enhanceable by zfh2^GD4506, Scer\GAL4^Su(H).GBE

(Rojas Villa et al., 2019)

InR^A1325D.UAS, Scer\GAL4^Su(H).GBE has intestinal stem cell | adult stage phenotype, non-enhanceable by zfh2^GD4506, Scer\GAL4^Su(H).GBE

(Rojas Villa et al., 2019)

InR^A1325D.UAS, Scer\GAL4^GMR.PF has eye phenotype, non-enhanceable by Prp4k^KK100483, Scer\GAL4^GMR.PF

(Cho et al., 2018)

Suppressed by

Statement

Reference

InR^A1325D.UAS, Scer\GAL4^salm.EPv has wing phenotype, suppressible by Ras85D^GD12553, Scer\GAL4^salm.EPv

(Vega-Cuesta et al., 2020)

InR^A1325D.UAS, Scer\GAL4^NP5130 has adult midgut phenotype, suppressible by Sams^KK107709, Scer\GAL4^NP5130

(Obata et al., 2018)

InR^A1325D.UAS, Scer\GAL4^Act5C.PP has nucleus | somatic clone | cell autonomous | larval stage phenotype, suppressible | somatic clone by Tl^10b.UAS.cUa, Scer\GAL4^Act5C.PP

(Roth et al., 2018)

InR^A1325D.UAS, Scer\GAL4^Act5C.PP has fat cell | somatic clone | cell autonomous | larval stage phenotype, suppressible | somatic clone by Tl^10b.UAS.cUa, Scer\GAL4^Act5C.PP

(Roth et al., 2018)

InR^A1325D.UAS, Scer\GAL4^insc-Mz1407 has neuroblast | third instar larval stage | nutrition conditional phenotype, suppressible by Chro^KK105370, Scer\GAL4^insc-Mz1407

(Li et al., 2017)

InR^A1325D.UAS, Scer\GAL4^ap-md544 has wing blade phenotype, suppressible by Sesn^d04539, Scer\GAL4^ap-md544

(Lee et al., 2010)

InR^A1325D.UAS, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Sesn^d04539, Scer\GAL4^GMR.PF

(Lee et al., 2010)

NOT suppressed by

Statement

Reference

InR^A1325D.UAS, Scer\GAL4^GMR.PFa has eye phenotype, non-suppressible by Zzzz\poly-GA^100.UAS, Scer\GAL4^GMR.PFa

(Morón-Oset et al., 2023)

InR^A1325D.UAS, Scer\GAL4^Su(H).GBE has adult gut phenotype, non-suppressible by zfh2^GD4506, Scer\GAL4^Su(H).GBE

(Rojas Villa et al., 2019)

InR^A1325D.UAS, Scer\GAL4^Su(H).GBE has enteroblast | adult stage phenotype, non-suppressible by zfh2^GD4506, Scer\GAL4^Su(H).GBE

(Rojas Villa et al., 2019)

InR^A1325D.UAS, Scer\GAL4^Su(H).GBE has intestinal stem cell | adult stage phenotype, non-suppressible by zfh2^GD4506, Scer\GAL4^Su(H).GBE

(Rojas Villa et al., 2019)

Enhancer of

Statement

Reference

InR^A1325D.UAS/Scer\GAL4^ppk.PG is an enhancer of larval dorsal multidendritic neuron ddaC | pupal stage | somatic clone phenotype of Mical¹⁵²⁵⁶

(Wong et al., 2013)

InR^A1325D.UAS, Scer\GAL4^GMR.PF is an enhancer of photoreceptor cell R8 phenotype of Scer\GAL4^GMR.PF, gogo^Scer\UAS.T1

(Mann et al., 2012)

InR^A1325D.UAS, Scer\GAL4^GMR.PF is an enhancer of medulla layer M1 phenotype of Scer\GAL4^GMR.PF, gogo^Scer\UAS.T1

(Mann et al., 2012)

NOT Enhancer of

Statement

Reference

InR^A1325D.UAS, Scer\GAL4^r4 is a non-enhancer of embryonic/larval fat body | larval stage phenotype of Scer\GAL4^r4, sog^GD3379

(Bakopoulos et al., 2023)

InR^A1325D.UAS, Scer\GAL4^r4 is a non-enhancer of embryonic/larval fat body | larval stage phenotype of Scer\GAL4^r4, mTor^DN.UAS.cUa

(Bakopoulos et al., 2023)

Suppressor of

Statement

Reference

InR^A1325D.UAS/Scer\GAL4^r4 is a suppressor | partially of larval muscle system | larval stage phenotype of Ncra\QF^QF2.Act5C.PL, Ras85D^V12.QUAS.cLa, scrib^{QUAS.HMS01490}

(Bakopoulos et al., 2023)

InR^A1325D.UAS, Scer\GAL4^r4, Mad^JF01264 is a suppressor | partially of larval muscle system | larval stage phenotype of Ncra\QF^QF2.Act5C.PL, Ras85D^V12.QUAS.cLa, scrib^{QUAS.HMS01490}

(Bakopoulos et al., 2023)

InR^A1325D.UAS, Scer\GAL4^r4, Mad^JF01264 is a suppressor | partially of muscle attachment site | larval stage phenotype of Ncra\QF^QF2.Act5C.PL, Ras85D^V12.QUAS.cLa, scrib^{QUAS.HMS01490}

(Bakopoulos et al., 2023)

InR^A1325D.UAS/Scer\GAL4^r4 is a suppressor | partially of muscle attachment site | larval stage phenotype of Ncra\QF^QF2.Act5C.PL, Ras85D^V12.QUAS.cLa, scrib^{QUAS.HMS01490}

(Bakopoulos et al., 2023)

InR^A1325D.UAS, Scer\GAL4^GMR.PFa is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PFa, Zzzz\poly-GA^400.UAS

(Morón-Oset et al., 2023)

InR^A1325D.UAS, Scer\GAL4^GMR.PFa is a suppressor of eye phenotype of Scer\GAL4^GMR.PFa, Zzzz\GGGGCC^36.UAS

(Atilano et al., 2021)

InR^A1325D.UAS, Scer\GAL4^Act5C.PP is a suppressor | somatic clone of nucleus | somatic clone | cell autonomous | larval stage phenotype of Scer\GAL4^Act5C.PP, Tl^10b.UAS.cUa

(Roth et al., 2018)

(Roth et al., 2018)

NOT Suppressor of

Statement

Reference

InR^A1325D.UAS, Scer\GAL4^r4 is a non-suppressor of embryonic/larval fat body | larval stage phenotype of Scer\GAL4^r4, sog^GD3379

(Bakopoulos et al., 2023)

InR^A1325D.UAS, Scer\GAL4^r4 is a non-suppressor of embryonic/larval fat body | larval stage phenotype of Scer\GAL4^r4, mTor^DN.UAS.cUa

(Bakopoulos et al., 2023)

InR^A1325D.UAS, Scer\GAL4^sca-537.4 is a non-suppressor of scutellar bristle phenotype of Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^sca-537.4

(Wang et al., 2008)

InR^A1325D.UAS, Scer\GAL4^en-e16E is a non-suppressor of wing | posterior phenotype of Hsap\TGIF2LX^UAS.Tag:MYC, Scer\GAL4^en-e16E

(Wang et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Adults co-expressing Edem1^GD3196 and InR^A1325D.UAS under the control of Scer\GAL4^ppl.PP are sensitive to starvation.

(Pathak and Varghese, 2021)

The increase in the number of proliferating (EdU+) cells observed in the posterior midgut of adult flies upon expression of InR^{A1325D.Scer\UAS} driven by Scer\GAL4^esg-NP5130 (combined with Gal80[ts] for temporal control) is completely abolished by co-expression of Sam-S^KK107709.

(Obata et al., 2018)

Larval fat body clones co-expressing Tl^10b.UAS.cUa and InR^A1325D.UAS under the control of Scer\GAL4^Act5C.PP, however, do not show exhibit the nucleus sizes increases and decreases respectively observed upon single expressions of Akt1^{UAS.Tag:Myr(Unk)} and Tl^10b.UAS.cUa.

(Roth et al., 2018)

The ability of Scer\GAL4^insc-Mz1407-driven expression of InR^{A1325D.Scer\UAS} to induce central brain neuroblast reactivation in the absence of dietary amino acids is prevented by co-expression of Chro^KK105370.

(Li et al., 2017)

Co-expression of bun^GD1392 suppresses the increased number of mitotic cells seen in the midguts of flies expressing InR^{A1325D.Scer\UAS} under the control of Scer\GAL4^esg-NP5130.

(Nie et al., 2015)

The increased cell-death phenotype of Csk^Q156Stop/Csk^Q156Stop somatic clones (induced specifically in the eye disc) expressing Ras85D^V12.Scer\UAS under Scer\GAL4^Act.PU is fully suppressed by co-expression of InR^{A1325D.Scer\UAS}, resulting in tumor overgrowth of the eye disc in nearly all larvae. Majority of the larvae fail to pupariate, the ones that manage do so with a significant delay.

(Hirabayashi et al., 2013)

Expression of InR^{A1325D.Scer\UAS} enhances the dendrite pruning defects seen in ddaC neurons expressing skpA^GD9251 under the control of Scer\GAL4^ppk.PG at 16 hours after pupariation.

Expression of InR^{A1325D.Scer\UAS} under the control of Scer\GAL4^ppk.PG enhances the dendrite pruning defects seen in Mical¹⁵²⁵⁶ mutant ddaC neuron clones at 16 hours after puparium formation.

(Wong et al., 2013)

Expression of InR^{A1325D.Scer\UAS} enhances the R8 photoreceptor phenotype seen when gogo^Scer\UAS.T1 is expressed under the control of Scer\GAL4^GMR.PF, resulting in an increase in the size of the blob-like structures seen in the medulla M1 layer. Many of the R8 axons terminate before reaching their final destination, the M3 layer. A number of axons also stop in the medulla M1 layer.

(Mann et al., 2012)

Co-expression of Sesn^d04539 with InR^{A1325D.Scer\UAS} via Scer\GAL4^GMR.PF suppresses the InR^{A1325D.Scer\UAS} hyperplastic eye phenotype.

Co-expression of Sesn^d04539 with InR^{A1325D.Scer\UAS} via Scer\GAL4^ap-md544 suppresses the InR^{A1325D.Scer\UAS} hyperplastic wing phenotype.

(Lee et al., 2010)

Xenogenetic Interactions

Statement

Reference

Expression of InR^{A1325D.Scer\UAS} is unable to suppress the growth phenotypes seen in the wings and bristles of flies expressing Hsap\TGIF2LX^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^en-e16E or Scer\GAL4^sca-537.4 respectively.

(Wang et al., 2008)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

8263

y¹ w¹¹¹⁸; P{UAS-InR.A1325D}2

8440

y¹ w¹¹¹⁸; P{GAL4-ninaE.GMR}12/CyO; P{UAS-InR.A1325D}3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

InR^{A1325D.Scer\UAS}

InR^A1325D.UAS

InR^A1325D

(Henstridge et al., 2018)

InR^ACT

(Sousa-Nunes et al., 2011)

InR^AD

(Huang and Wang, 2018)

InRCA

(Li et al., 2017)

inR^CA

(Hirabayashi et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (44)

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