FlyBase Allele Report: Hsap\ATXN8OS[CTG112.UAS]

General Information

Symbol

Hsap\ATXN8OS^CTG112.UAS

Species

H. sapiens

Name

FlyBase ID

FBal0156378

Feature type

allele

Associated gene

Hsap\ATXN8OS

Associated Insertion(s)

Carried in Construct

P{UAS-SCA8.CTG112}

Key Links

Allele class

Mutagen

in vitro construct - regulatory fusion

Nature of the Allele

Allele class

Mutagen

in vitro construct - regulatory fusion

(Mutsuddi et al., 2004)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Carried in construct

P{UAS-SCA8.CTG112}

Cytology

Nature of the lesion

Statement

Reference

UAS regulatory sequences drive expression of exons D, C3, C2 and A of a Hsap\ATXN8OS cDNA. This construct contains a pathogenic, expanded configuration of CTG repeats which has the configuration CTA₃CTG₅CCG₃CTG₁₁₂.

(Mutsuddi et al., 2004)

Allele components

Product class / Tool use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\ATXN8OS

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of autosomal dominant cerebellar ataxia

CEA

(Mutsuddi et al., 2004)

model of spinocerebellar ataxia type 8

CEA

(Tripathi et al., 2016)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of autosomal dominant cerebellar ataxia

is ameliorated by eIF3e¹⁰⁵⁴⁷

(Mutsuddi et al., 2004)

is exacerbated by Eip75B⁰⁷⁰⁴¹

(Mutsuddi et al., 2004)

is exacerbated by stau^ry9

(Mutsuddi et al., 2004)

is exacerbated by hoip^k07104

(Mutsuddi et al., 2004)

is exacerbated by Vha36-1^k07207

(Mutsuddi et al., 2004)

is exacerbated by spen^XFM911

(Mutsuddi et al., 2004)

is exacerbated by mbl^E16

(Mutsuddi et al., 2004)

is exacerbated by ttv^k11904

(Mutsuddi et al., 2004)

is ameliorated by mod(mdg4)^L3101

(Mutsuddi et al., 2004)

is exacerbated by lolal^k02512

(Mutsuddi et al., 2004)

is exacerbated by stau²

(Mutsuddi et al., 2004)

is exacerbated by mbl^k07103

(Mutsuddi et al., 2004)

is ameliorated by l(3)09070⁰⁹⁰⁷⁰

(Mutsuddi et al., 2004)

is exacerbated by Patronin^k07433

(Mutsuddi et al., 2004)

is ameliorated by hrg^k07619

(Mutsuddi et al., 2004)

is ameliorated by l(2)k09854^k09854

(Mutsuddi et al., 2004)

is exacerbated by spoon^KG02745

(Mutsuddi et al., 2004)

is exacerbated by px^k08316

(Mutsuddi et al., 2004)

is ameliorated by Psc^k07834

(Mutsuddi et al., 2004)

is exacerbated by Pcf11^k08015

(Mutsuddi et al., 2004)

is exacerbated by stau¹

(Mutsuddi et al., 2004)

is exacerbated by mbl^k01212

(Mutsuddi et al., 2004)

is exacerbated by spen^AH393

(Mutsuddi et al., 2004)

is ameliorated by spoon^EP1400

(Mutsuddi et al., 2004)

is exacerbated by Sac1^BG02228

(Mutsuddi et al., 2004)

is ameliorated by Cse1^k03902

(Mutsuddi et al., 2004)

is ameliorated by atms^rK509

(Mutsuddi et al., 2004)

is exacerbated by Ate1^k10809

(Mutsuddi et al., 2004)

is ameliorated by l(2)k04308^k04308

(Mutsuddi et al., 2004)

is exacerbated by ThrRS^k04203

(Mutsuddi et al., 2004)

is exacerbated by mbl^E27

(Mutsuddi et al., 2004)

is ameliorated by S6k⁰⁷⁰⁸⁴

(Mutsuddi et al., 2004)

is ameliorated by wcd^k07824

(Mutsuddi et al., 2004)

is exacerbated by l(3)j1E7^j1E7

(Mutsuddi et al., 2004)

is ameliorated by l(3)L1820^L1820

(Mutsuddi et al., 2004)

is exacerbated by l(2)k10217^k10217

(Mutsuddi et al., 2004)

is ameliorated by RnrL^k06709

(Mutsuddi et al., 2004)

model of spinocerebellar ataxia type 8

is ameliorated by spoon^UAS.Tag:HA

(Tripathi et al., 2016)

is ameliorated by spoon^{KH.UAS.Tag:HA}

(Tripathi et al., 2016)

is exacerbated by spoon^EP1400

(Tripathi et al., 2016)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

This allele represents a human variant implicated in disease.

(Mutsuddi et al., 2004)

ATXN8OS:n.1103[112CTG]

(FlyBase curators, 2019-)

Variants Synonym(s)

ATXN8, (CAG)n REPEAT EXPANSION

ATXN8OS, (CTG)n REPEAT EXPANSION

Associated human disease model(s)

spinocerebellar ataxia 8

External database links

ClinVar: ATXN8OS_562101

Comments concerning this variant

Non-coding gene.

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

abnormal neuroanatomy, with Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

increased cell death | third instar larval stage, with Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

visible, with Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

visible | adult stage, with Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

visible | adult stage | progressive, with Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

Phenotype Manifest In

cytoplasm | third instar larval stage, with Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

eye, with Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

eye disc | third instar larval stage, with Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

eye photoreceptor cell & neuron, with Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

interommatidial bristle, with Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

nucleus | third instar larval stage, with Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

ommatidium, with Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

ommatidium, with Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

optic nerve, with Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

pigment cell, with Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

retina, with Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

wing | progressive, with Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

Detailed Description

Statement

Reference

Expression of Hsap\ATXN8OS^{CTG112.Scer\UAS} under the control of Scer\GAL4^GMR.PU results in disorganization of the ommatidial array in adult eyes associated with neurodegeneration (irregular and disarrayed axonal projections in the optic nerve as well as increased cell death of the developing photoreceptor neurons in third instar larval eye discs). This ectopic expression also induces the formation of toxic RNAi foci containing the mutant transcript in the nucleus and to a lesser extent also the cytoplasm of larval eye disc cells.

Scer\GAL4^Mhc.F3-580-driven expression of Hsap\ATXN8OS^{CTG112.Scer\UAS} leads to age-progressive wing posture (drooped wings, which in time result in held-up wing phenotype) and climbing ability defects in adult flies.

(Tripathi et al., 2016)

Expression of Hsap\SCA8^{CTG112.Scer\UAS} under the control of Scer\GAL4^GMR.PF results in disorganisation of the ommatidia and mechanosensory bristles of the eye, with the central portion of the eye being most severely affected. The penetrance of the phenotype is variable. The retina of 1- to 2-day old flies expressing Hsap\SCA8^{CTG112.Scer\UAS} under the control of Scer\GAL4^GMR.PF shows mild disorganisation with a loss of photoreceptor neurons and pigment cells. This retinal degeneration becomes progressively more severe as the flies age, with photoreceptor neurons becoming rod shaped and fragmented, resulting in vacuole formation. The recruitment and differentiation of photoreceptor neurons in larval eye discs expressing Hsap\SCA8^{CTG112.Scer\UAS} under the control of Scer\GAL4^GMR.PF appears to be normal, with degeneration of the photoreceptors appearing to begin during the pupal stages.

(Mutsuddi et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by spoon^KG02745/spoon^KG02745

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has increased cell death | third instar larval stage phenotype, enhanceable by spoon^KG02745/spoon^KG02745

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, enhanceable by stau²

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, enhanceable by mbl^E16

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, enhanceable by Aats-thr[+]/ThrRS^k04203

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, enhanceable by Ate1[+]/Ate1^k10809

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, enhanceable by Eip75B[+]/Eip75B⁰⁷⁰⁴¹

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, enhanceable by Sac1[+]/Sac1^BG02228

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, enhanceable by Vha36-1^k07207/Vha36[+]

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, enhanceable by hoip[+]/hoip^k07104

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, enhanceable by l(2)k07433[+]/Patronin^k07433

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, enhanceable by Pcf11^k08015/Pcf11[+]

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, enhanceable by l(2)k10217^k10217/l(2)k10217[+]/l(2)k10217^k10217

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, enhanceable by l(3)j1E7[+]/l(3)j1E7^j1E7

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, enhanceable by mbl^E27

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, enhanceable by mbl^k01212

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, enhanceable by mbl^k07103

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, enhanceable by px[+]/px^k08316

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, enhanceable by spen^XFM911

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, enhanceable by stau¹

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, enhanceable by stau^ry9

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, enhanceable by ttv^k11904/ttv[+]

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, enhanceable by lolal^k02512/lolal[+]

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, enhanceable by spoon^KG02745

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, enhanceable by spen^AH393

(Mutsuddi et al., 2004)

NOT Enhanced by

Statement

Reference

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by P{EP}RnpS1^EP1082, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by apt^EP2339, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by eIF4E1^EP568, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by eIF4A^EP1011, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by B52^s2249

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by Fmr1^Δ50M/Df(3R)by62

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by Sxl^f18

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by apt⁰³⁰⁴¹

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by apt^k15608

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by bru1⁰¹²⁸⁴

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by bru1^BG00614

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by egl^EP938, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by cpo⁰¹⁴³²

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by eIF4E1⁰⁷²³⁸

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by eIF4A^k01501

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by egl¹²⁸⁶

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by elav⁴

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by elav^C155

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by heph²

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by msi¹

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by msi²

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by mub⁰⁴⁰⁹³

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by qkr58E-1^EP2103, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by nonA^4b18

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by orb^dec

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by pum⁰¹⁶⁸⁸

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by pum³

(Mutsuddi et al., 2004)

Suppressed by

Statement

Reference

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by spoon^UAS.Tag:HA, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has increased cell death | third instar larval stage phenotype, suppressible by spoon^UAS.Tag:HA, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by spoon^{KH.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has increased cell death | third instar larval stage phenotype, suppressible by spoon^{KH.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580 has visible | adult stage | progressive phenotype, suppressible | partially by spoon^UAS.Tag:HA, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580 has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible | partially by spoon^UAS.Tag:HA, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580 has visible | adult stage | progressive phenotype, suppressible | partially by spoon^{KH.UAS.Tag:HA}, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580 has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible | partially by spoon^{KH.UAS.Tag:HA}, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, suppressible by spoon^EP1400, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, suppressible by Cas[+]/Cse1^k03902

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, suppressible by Int6[+]/eIF3e¹⁰⁵⁴⁷

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, suppressible by Psc[+]/Psc^k07834

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, suppressible by RnrL^k06709/RnrL[+]

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, suppressible by S6k[+]/S6k⁰⁷⁰⁸⁴

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, suppressible by atms[+]/atms^rK509

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, suppressible by hrg^k07619/hrg[+]

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, suppressible by l(2)k04308^k04308/l(2)k04308[+]

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, suppressible by l(2)k07824[+]/wcd^k07824

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, suppressible by l(2)k09854^k09854/l(2)k09854[+]

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, suppressible by l(3)09070⁰⁹⁰⁷⁰/l(3)09070[+]

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, suppressible by l(3)L1820[+]/l(3)L1820^L1820

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, suppressible by mod(mdg4)^L3101/mod(mdg4)[+]

(Mutsuddi et al., 2004)

NOT suppressed by

Statement

Reference

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has visible | adult stage phenotype, non-suppressible by spoon^{Tudor.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has increased cell death | third instar larval stage phenotype, non-suppressible by spoon^{Tudor.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580 has visible | adult stage | progressive phenotype, non-suppressible by spoon^{Tudor.UAS.Tag:HA}, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580 has abnormal locomotor behavior | adult stage | progressive phenotype, non-suppressible by spoon^{Tudor.UAS.Tag:HA}, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by Sxl^f18

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by apt⁰³⁰⁴¹

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by apt^k15608

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by bru1⁰¹²⁸⁴

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by bru1^BG00614

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by cpo⁰¹⁴³²

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by eIF4E1⁰⁷²³⁸

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by eIF4A^k01501

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by egl¹²⁸⁶

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by elav⁴

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by P{EP}RnpS1^EP1082, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by elav^C155

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by heph²

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by msi¹

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by msi²

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by mub⁰⁴⁰⁹³

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by nonA^4b18

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by orb^dec

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by pum⁰¹⁶⁸⁸

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by pum³

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by apt^EP2339, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by eIF4E1^EP568, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by eIF4A^EP1011, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by egl^EP938, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by qkr58E-1^EP2103, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by B52^s2249

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by Fmr1^Δ50M/Df(3R)by62

(Mutsuddi et al., 2004)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by spoon^KG02745/spoon^KG02745

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has ommatidium phenotype, enhanceable by spoon^KG02745/spoon^KG02745

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has optic nerve phenotype, enhanceable by spoon^KG02745/spoon^KG02745

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has eye disc | third instar larval stage phenotype, enhanceable by spoon^KG02745/spoon^KG02745

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has ommatidium phenotype, enhanceable by stau²

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has eye photoreceptor cell phenotype, enhanceable by mbl^E16

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has pigment cell phenotype, enhanceable by mbl^E16

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has ommatidium phenotype, enhanceable by spoon^KG02745

(Mutsuddi et al., 2004)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has ommatidium phenotype, enhanceable by spen^AH393

(Mutsuddi et al., 2004)

Suppressed by

Statement

Reference

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by spoon^UAS.Tag:HA, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has ommatidium phenotype, suppressible by spoon^UAS.Tag:HA, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has optic nerve phenotype, suppressible by spoon^UAS.Tag:HA, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has eye disc | third instar larval stage phenotype, suppressible by spoon^UAS.Tag:HA, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has nucleus | third instar larval stage phenotype, suppressible by spoon^UAS.Tag:HA, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has cytoplasm | third instar larval stage phenotype, suppressible by spoon^UAS.Tag:HA, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has eye phenotype, suppressible by spoon^{KH.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has ommatidium phenotype, suppressible by spoon^{KH.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has optic nerve phenotype, suppressible by spoon^{KH.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has eye disc | third instar larval stage phenotype, suppressible by spoon^{KH.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has nucleus | third instar larval stage phenotype, suppressible by spoon^{KH.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has cytoplasm | third instar larval stage phenotype, suppressible by spoon^{KH.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580 has wing | progressive phenotype, suppressible | partially by spoon^UAS.Tag:HA, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580 has wing | progressive phenotype, suppressible | partially by spoon^{KH.UAS.Tag:HA}, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF has ommatidium phenotype, suppressible by spoon^EP1400, Scer\GAL4^GMR.PF/Scer\GAL4^GMR.PF

(Mutsuddi et al., 2004)

NOT suppressed by

Statement

Reference

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has eye phenotype, non-suppressible by spoon^{Tudor.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has ommatidium phenotype, non-suppressible by spoon^{Tudor.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has eye disc | third instar larval stage phenotype, non-suppressible by spoon^{Tudor.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has nucleus | third instar larval stage phenotype, non-suppressible by spoon^{Tudor.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^GMR.PU has cytoplasm | third instar larval stage phenotype, non-suppressible by spoon^{Tudor.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Tripathi et al., 2016)

Hsap\ATXN8OS^CTG112.UAS, Scer\GAL4^Mhc.F3-580 has wing | progressive phenotype, non-suppressible by spoon^{Tudor.UAS.Tag:HA}, Scer\GAL4^Mhc.F3-580

(Tripathi et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The disorganization of the adult eye ommatidial lattice, disarrayed axonal projection in the optic nerve along with the increased cell death of developing photoreceptors and formation of nuclear as well as cytoplasmic toxic RNAi foci in larval eye discs characteristic for flies expressing Hsap\ATXN8OS^{CTG112.Scer\UAS} under the control of Scer\GAL4^GMR.PU is significantly improved by co-expression of either spoon^UAS.Tag:HA or spoon^{KH.UAS.Tag:HA} but not spoon^{Tudor.UAS.Tag:HA}. The ommatidial disorganization and the associated neurodegeneration is further enhanced by spoon^KG02745 homozygosity.

Similarly, expression of spoon^UAS.Tag:HA and spoon^{KH.UAS.Tag:HA} (but not spoon^{Tudor.UAS.Tag:HA}) ameliorates the age-progressive wing posture and climbing ability defects in flies expressing Hsap\ATXN8OS^{CTG9.Scer\UAS} under the Scer\GAL4^Mhc.F3-580 driver.

(Tripathi et al., 2016)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hsap\ATXN8OS^{CTG112.Scer\UAS}

Hsap\ATXN8OS^CTG112.UAS

Hsap\SCA8^{CTG112.Scer\UAS}

Name Synonyms

Secondary FlyBase IDs

References (4)

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