UAS regulatory sequences drive expression of exons D, C3, C2 and A of a Hsap\ATXN8OS cDNA. This construct contains a pathogenic, expanded configuration of CTG repeats which has the configuration CTA3CTG5CCG3CTG112.
Non-coding gene.
eye photoreceptor cell & neuron, with Scer\GAL4GMR.PF
Expression of Hsap\ATXN8OSCTG112.Scer\UAS under the control of Scer\GAL4GMR.PU results in disorganization of the ommatidial array in adult eyes associated with neurodegeneration (irregular and disarrayed axonal projections in the optic nerve as well as increased cell death of the developing photoreceptor neurons in third instar larval eye discs). This ectopic expression also induces the formation of toxic RNAi foci containing the mutant transcript in the nucleus and to a lesser extent also the cytoplasm of larval eye disc cells.
Scer\GAL4Mhc.F3-580-driven expression of Hsap\ATXN8OSCTG112.Scer\UAS leads to age-progressive wing posture (drooped wings, which in time result in held-up wing phenotype) and climbing ability defects in adult flies.
Expression of Hsap\SCA8CTG112.Scer\UAS under the control of Scer\GAL4GMR.PF results in disorganisation of the ommatidia and mechanosensory bristles of the eye, with the central portion of the eye being most severely affected. The penetrance of the phenotype is variable. The retina of 1- to 2-day old flies expressing Hsap\SCA8CTG112.Scer\UAS under the control of Scer\GAL4GMR.PF shows mild disorganisation with a loss of photoreceptor neurons and pigment cells. This retinal degeneration becomes progressively more severe as the flies age, with photoreceptor neurons becoming rod shaped and fragmented, resulting in vacuole formation. The recruitment and differentiation of photoreceptor neurons in larval eye discs expressing Hsap\SCA8CTG112.Scer\UAS under the control of Scer\GAL4GMR.PF appears to be normal, with degeneration of the photoreceptors appearing to begin during the pupal stages.
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has visible | adult stage phenotype, enhanceable by spoonKG02745/spoonKG02745
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has increased cell death | third instar larval stage phenotype, enhanceable by spoonKG02745/spoonKG02745
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, enhanceable by stau2
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, enhanceable by mblE16
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, enhanceable by Aats-thr[+]/ThrRSk04203
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, enhanceable by Ate1[+]/Ate1k10809
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, enhanceable by Eip75B[+]/Eip75B07041
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, enhanceable by Sac1[+]/Sac1BG02228
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, enhanceable by Vha36-1k07207/Vha36[+]
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, enhanceable by hoip[+]/hoipk07104
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, enhanceable by l(2)k07433[+]/Patronink07433
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, enhanceable by Pcf11k08015/Pcf11[+]
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, enhanceable by l(2)k10217k10217/l(2)k10217[+]/l(2)k10217k10217
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, enhanceable by l(3)j1E7[+]/l(3)j1E7j1E7
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, enhanceable by mblE27
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, enhanceable by mblk01212
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, enhanceable by mblk07103
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, enhanceable by px[+]/pxk08316
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, enhanceable by spenXFM911
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, enhanceable by stau1
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, enhanceable by staury9
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, enhanceable by ttvk11904/ttv[+]
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, enhanceable by lolalk02512/lolal[+]
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, enhanceable by spoonKG02745
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, enhanceable by spenAH393
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by P{EP}RnpS1EP1082, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by aptEP2339, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by eIF4E1EP568, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by eIF4AEP1011, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by B52s2249
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by Fmr1Δ50M/Df(3R)by62
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by Sxlf18
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by apt03041
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by aptk15608
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by bru101284
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by bru1BG00614
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by eglEP938, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by cpo01432
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by eIF4E107238
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by eIF4Ak01501
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by egl1286
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by elav4
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by elavC155
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by heph2
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by msi1
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by msi2
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by mub04093
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by qkr58E-1EP2103, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by nonA4b18
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by orbdec
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by pum01688
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-enhanceable by pum3
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has visible | adult stage phenotype, suppressible by spoonUAS.Tag:HA, Scer\GAL4GMR.PU
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has increased cell death | third instar larval stage phenotype, suppressible by spoonUAS.Tag:HA, Scer\GAL4GMR.PU
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has visible | adult stage phenotype, suppressible by spoonKH.UAS.Tag:HA, Scer\GAL4GMR.PU
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has increased cell death | third instar larval stage phenotype, suppressible by spoonKH.UAS.Tag:HA, Scer\GAL4GMR.PU
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4Mhc.F3-580 has visible | adult stage | progressive phenotype, suppressible | partially by spoonUAS.Tag:HA, Scer\GAL4Mhc.F3-580
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4Mhc.F3-580 has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible | partially by spoonUAS.Tag:HA, Scer\GAL4Mhc.F3-580
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4Mhc.F3-580 has visible | adult stage | progressive phenotype, suppressible | partially by spoonKH.UAS.Tag:HA, Scer\GAL4Mhc.F3-580
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4Mhc.F3-580 has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible | partially by spoonKH.UAS.Tag:HA, Scer\GAL4Mhc.F3-580
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, suppressible by spoonEP1400, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, suppressible by Cas[+]/Cse1k03902
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, suppressible by Int6[+]/eIF3e10547
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, suppressible by Psc[+]/Psck07834
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, suppressible by RnrLk06709/RnrL[+]
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, suppressible by S6k[+]/S6k07084
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, suppressible by atms[+]/atmsrK509
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, suppressible by hrgk07619/hrg[+]
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, suppressible by l(2)k04308k04308/l(2)k04308[+]
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, suppressible by l(2)k07824[+]/wcdk07824
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, suppressible by l(2)k09854k09854/l(2)k09854[+]
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, suppressible by l(3)0907009070/l(3)09070[+]
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, suppressible by l(3)L1820[+]/l(3)L1820L1820
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, suppressible by mod(mdg4)L3101/mod(mdg4)[+]
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has visible | adult stage phenotype, non-suppressible by spoonTudor.UAS.Tag:HA, Scer\GAL4GMR.PU
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has increased cell death | third instar larval stage phenotype, non-suppressible by spoonTudor.UAS.Tag:HA, Scer\GAL4GMR.PU
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4Mhc.F3-580 has visible | adult stage | progressive phenotype, non-suppressible by spoonTudor.UAS.Tag:HA, Scer\GAL4Mhc.F3-580
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4Mhc.F3-580 has abnormal locomotor behavior | adult stage | progressive phenotype, non-suppressible by spoonTudor.UAS.Tag:HA, Scer\GAL4Mhc.F3-580
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by Sxlf18
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by apt03041
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by aptk15608
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by bru101284
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by bru1BG00614
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by cpo01432
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by eIF4E107238
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by eIF4Ak01501
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by egl1286
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by elav4
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by P{EP}RnpS1EP1082, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by elavC155
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by heph2
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by msi1
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by msi2
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by mub04093
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by nonA4b18
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by orbdec
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by pum01688
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by pum3
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by aptEP2339, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by eIF4E1EP568, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by eIF4AEP1011, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by eglEP938, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by qkr58E-1EP2103, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by B52s2249
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has abnormal neuroanatomy phenotype, non-suppressible by Fmr1Δ50M/Df(3R)by62
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has eye phenotype, enhanceable by spoonKG02745/spoonKG02745
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has ommatidium phenotype, enhanceable by spoonKG02745/spoonKG02745
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has optic nerve phenotype, enhanceable by spoonKG02745/spoonKG02745
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has eye disc | third instar larval stage phenotype, enhanceable by spoonKG02745/spoonKG02745
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has ommatidium phenotype, enhanceable by stau2
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has eye photoreceptor cell phenotype, enhanceable by mblE16
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has pigment cell phenotype, enhanceable by mblE16
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has ommatidium phenotype, enhanceable by spoonKG02745
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has ommatidium phenotype, enhanceable by spenAH393
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has eye phenotype, suppressible by spoonUAS.Tag:HA, Scer\GAL4GMR.PU
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has ommatidium phenotype, suppressible by spoonUAS.Tag:HA, Scer\GAL4GMR.PU
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has optic nerve phenotype, suppressible by spoonUAS.Tag:HA, Scer\GAL4GMR.PU
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has eye disc | third instar larval stage phenotype, suppressible by spoonUAS.Tag:HA, Scer\GAL4GMR.PU
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has nucleus | third instar larval stage phenotype, suppressible by spoonUAS.Tag:HA, Scer\GAL4GMR.PU
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has cytoplasm | third instar larval stage phenotype, suppressible by spoonUAS.Tag:HA, Scer\GAL4GMR.PU
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has eye phenotype, suppressible by spoonKH.UAS.Tag:HA, Scer\GAL4GMR.PU
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has ommatidium phenotype, suppressible by spoonKH.UAS.Tag:HA, Scer\GAL4GMR.PU
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has optic nerve phenotype, suppressible by spoonKH.UAS.Tag:HA, Scer\GAL4GMR.PU
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has eye disc | third instar larval stage phenotype, suppressible by spoonKH.UAS.Tag:HA, Scer\GAL4GMR.PU
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has nucleus | third instar larval stage phenotype, suppressible by spoonKH.UAS.Tag:HA, Scer\GAL4GMR.PU
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has cytoplasm | third instar larval stage phenotype, suppressible by spoonKH.UAS.Tag:HA, Scer\GAL4GMR.PU
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4Mhc.F3-580 has wing | progressive phenotype, suppressible | partially by spoonUAS.Tag:HA, Scer\GAL4Mhc.F3-580
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4Mhc.F3-580 has wing | progressive phenotype, suppressible | partially by spoonKH.UAS.Tag:HA, Scer\GAL4Mhc.F3-580
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF has ommatidium phenotype, suppressible by spoonEP1400, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has eye phenotype, non-suppressible by spoonTudor.UAS.Tag:HA, Scer\GAL4GMR.PU
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has ommatidium phenotype, non-suppressible by spoonTudor.UAS.Tag:HA, Scer\GAL4GMR.PU
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has eye disc | third instar larval stage phenotype, non-suppressible by spoonTudor.UAS.Tag:HA, Scer\GAL4GMR.PU
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has nucleus | third instar larval stage phenotype, non-suppressible by spoonTudor.UAS.Tag:HA, Scer\GAL4GMR.PU
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PU has cytoplasm | third instar larval stage phenotype, non-suppressible by spoonTudor.UAS.Tag:HA, Scer\GAL4GMR.PU
Hsap\ATXN8OSCTG112.UAS, Scer\GAL4Mhc.F3-580 has wing | progressive phenotype, non-suppressible by spoonTudor.UAS.Tag:HA, Scer\GAL4Mhc.F3-580
The disorganization of the adult eye ommatidial lattice, disarrayed axonal projection in the optic nerve along with the increased cell death of developing photoreceptors and formation of nuclear as well as cytoplasmic toxic RNAi foci in larval eye discs characteristic for flies expressing Hsap\ATXN8OSCTG112.Scer\UAS under the control of Scer\GAL4GMR.PU is significantly improved by co-expression of either spoonUAS.Tag:HA or spoonKH.UAS.Tag:HA but not spoonTudor.UAS.Tag:HA. The ommatidial disorganization and the associated neurodegeneration is further enhanced by spoonKG02745 homozygosity.
Similarly, expression of spoonUAS.Tag:HA and spoonKH.UAS.Tag:HA (but not spoonTudor.UAS.Tag:HA) ameliorates the age-progressive wing posture and climbing ability defects in flies expressing Hsap\ATXN8OSCTG9.Scer\UAS under the Scer\GAL4Mhc.F3-580 driver.