FB2025_01 , released February 20, 2025
Allele: Dmel\SREBPCdel.UAS
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General Information
Symbol
Dmel\SREBPCdel.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0156414
Feature type
allele
Associated gene
Dmel\SREBP
Associated Insertion(s)
Carried in Construct
P{UAS-SREBP.Cdel}
Key Links
Transgenic product class
inframe_deletion
(Parks, 2004.5.12)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Parks, 2004.5.12)
Mutagen
in vitro construct
(Parks, 2004.5.12)
Progenitor genotype
SREBPUAS.Exel
(Parks, 2004.5.12)
Carried in construct
P{UAS-SREBP.Cdel}
Cytology
Description

UAS regulatory sequences drive expression of mature SREBP.

(Porstmann et al., 2008)

SREBP sequences encoding a constitutively active protein variant truncated right before the first transmembrane domain were cloned into P{Express-UAS}. The C terminal sequence is RGMATNSR. The variant protein is localized to the nucleus constitutively and is constitutively active.

(Parks, 2004.5.12)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
SREBP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  heart conduction disease
      CEA with SREBPUAS.Exel
      (Lim et al., 2011)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of an active form of SREBP in enterocytes, through expression of SREBPCdel.Scer\UAS under the control of Scer\GAL4Myo31DF-NP0001 results in an increase in intestinal lipid production and whole-body triglyceride storage.

      (Song et al., 2014)

      Expression of HLH106Cdel.Scer\UAS under the control of Scer\GAL4HCH.Hand results in a reduction in diastolic and systolic diameters and a reduction in the average heart period length in the adult heart compared to controls. Upon being subjected to pacing-induced stress, hearts expressing HLH106Cdel.Scer\UAS under the control of Scer\GAL4HCH.Hand show higher rates of heart failure compared to control hearts at young ages (1 week).

      Expression of HLH106Cdel.Scer\UAS under the control of Scer\GAL4HCH.Hand causes significant loss of longitudinal fibres and disarrayed inner transverse myofibrils in the adult heart.

      (Lim et al., 2011)

      Expression of HLH106Cdel.Scer\UAS under the control of Scer\GAL4Bx-MS1096 results in significant lethality at 25[o]C. At 18[o]C, flies with a severe deformation of the wing are seen.

      (Porstmann et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      HLH106Cdel.Scer\UAS
      SREBPCdel.Scer\UAS
      SREBPCdel.UAS
      dSREBPACT
      (Lim et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)