Allele Dmel\E(br)65^Ebr65

General Information
Symbol	Dmel\E(br)65^Ebr65	Species	D. melanogaster
Name		FlyBase ID	FBal0156616
Feature type	allele	Associated gene	Dmel\E(br)65

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Ward et al., 2003)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage \| recessive (Ward et al., 2003) lethal \| larval stage \| recessive (Ward et al., 2003)
Phenotype Manifest In
	embryonic/first instar larval cuticle \| anterior (Ward et al., 2003)
Detailed Description
	Statement Reference 2% of heterozygotes show a malformed leg phenotype. Homozygotes show 14 +/- 9% embryonic lethality and 100% of homozygous larvae fail to form pupae. Homozygous embryos show an anterior open cuticle phenotype. (Ward et al., 2003)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference E(br)65^Ebr65/E(br)65[+] is an enhancer of visible phenotype of br¹ (Ward et al., 2003)
Other
Statement Reference E(br)65^Ebr65, br⁵/br[+] has visible \| dominant phenotype (Ward et al., 2003) E(br)65^Ebr65, Rho1^J3.8/Rho1[+] has visible \| dominant phenotype (Ward et al., 2003) E(br)65^Ebr65, RhoGEF2^11-3/RhoGEF2[+] has visible \| dominant phenotype (Ward et al., 2003) E(br)65^Ebr65, zip[+]/zip^Ebr has visible \| dominant phenotype (Ward et al., 2003) E(br)65^Ebr65/E(br)65[+], br⁵ has visible phenotype (Ward et al., 2003) E(br)65^Ebr65/E(br)65[+], Rho1^J3.8 has visible phenotype (Ward et al., 2003) E(br)65^Ebr65/E(br)65[+], RhoGEF2^11-3 has visible phenotype (Ward et al., 2003) E(br)65^Ebr65/E(br)65[+], zip^Ebr has visible phenotype (Ward et al., 2003)
Phenotype Manifest In
Enhancer of
Statement Reference E(br)65^Ebr65/E(br)65[+] is an enhancer of leg phenotype of br¹ (Ward et al., 2003)
Other
Statement Reference E(br)65^Ebr65, br⁵/br[+] has leg phenotype (Ward et al., 2003) E(br)65^Ebr65, br⁵ has leg phenotype (Ward et al., 2003) E(br)65^Ebr65, Rho1^J3.8/Rho1[+] has leg phenotype (Ward et al., 2003) E(br)65^Ebr65, Rho1^J3.8 has leg phenotype (Ward et al., 2003) E(br)65^Ebr65, RhoGEF2^11-3/RhoGEF2[+] has leg phenotype (Ward et al., 2003) E(br)65^Ebr65, RhoGEF2^11-3 has leg phenotype (Ward et al., 2003) E(br)65^Ebr65, zip[+]/zip^Ebr has leg phenotype (Ward et al., 2003) E(br)65^Ebr65, zip^Ebr has leg phenotype (Ward et al., 2003)
Additional Comments
Genetic Interactions
Statement Reference 45% of br¹ ; E(br)65^Ebr65/+ flies show a malformed leg phenotype. The predominant leg phenotype in br¹/Y ; E(br)65^Ebr65/+ flies is short, fat femurs and tibias. 17% of br⁵/+ ; E(br)65^Ebr65/+ flies show a malformed leg phenotype. 28% of E(br)65^Ebr65 Rho1^J3.8 double heterozygotes show a malformed leg phenotype in at least one leg. 6% of E(br)65^Ebr65 Rho1^k02107b double heterozygotes show a malformed leg phenotype in at least one leg. 16% of E(br)65^Ebr65 Rho1^E3.10 double heterozygotes show a malformed leg phenotype in at least one leg. 4% of E(br)65^Ebr65 RhoGEF2⁰⁴²⁹¹ double heterozygotes show a malformed leg phenotype in at least one leg. 28% of E(br)65^Ebr65 RhoGEF2^11-3 double heterozygotes show a malformed leg phenotype in at least one leg. 67% of E(br)65^Ebr65 zip^Ebr double heterozygotes show a malformed leg phenotype in at least one leg. 2% of E(br)65^Ebr65 zip¹ double heterozygotes show a malformed leg phenotype in at least one leg. 7% of E(br)65^Ebr65 zip^33-1 double heterozygotes show a malformed leg phenotype in at least one leg. (Ward et al., 2003)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer
	Selected as: a mutation that enhances the br¹ malformed leg phenotype. (Ward et al., 2003)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	E(br)65 (Ward et al., 2003) E(br)65^Ebr65
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Ward et al., 2003, Genetics 165(3): 1397--1415 Genetic modifier screens in Drosophila demonstrate a role for Rho1 signaling in ecdysone-triggered imaginal disc morphogenesis. [FBrf0167639]

Allele Dmel\E(br)65Ebr65

Allele Dmel\E(br)65^Ebr65